Validation of the STR DXS7424 and the linkage situation on the X-chromosome

Edelmann, Jeanett; Hering, Sandra; Kuhlisch, Eberhard; Szibor, R.

doi:10.1016/s0379-0738(02)00005-1

Cited by 91 publications

(67 citation statements)

References 19 publications

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“…In the recent past, a large number of X-STRs spanning the entire human X chromosome have been described [1][2][3][4][5]. Joint consideration of XSTRs can yield even more complex and informative genetic systems provided that the probability of inter-marker recombination is negligible and that haplotypes therefore segregate stably within families.…”

Section: Introductionmentioning

confidence: 99%

Collaborative genetic mapping of 12 forensic short tandem repeat (STR) loci on the human X chromosome

Nothnagel

Szibor

Vollrath

et al. 2012

Forensic Science International: Genetics

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Section: Introductionmentioning

confidence: 99%

Collaborative genetic mapping of 12 forensic short tandem repeat (STR) loci on the human X chromosome

Nothnagel

Szibor

Vollrath

et al. 2012

Forensic Science International: Genetics

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“…We used seven different polymorphic markers on the X chromosome (% heterozygosity is shown in parentheses): DXS9895 (0.73) (Son et al, 2002); DXS7132 (0.69) (Son et al, 2002); DXS6803 (0.69) (Huang et al, 2003); DXS9898 (0.67) (Son et al, 2002); DXS 6789 (0.84) (Son et al, 2002); DXS 101 (0.88) (Edelmann and Szibor, 2001); DXS 7424 (0.84) (Edelmann et al, 2002). Representative chromatographs, using DXS6803, DXS9898, and DXS6789 of the patient PBLs and PSK-1 are shown (Figure 1d).…”

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confidence: 99%

Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells

et al. 2004

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The increased risk of several types of cancer in Klinefelter syndrome (47XXY) suggests that the extra X chromosome may be involved in the tumorigenesis associated with this syndrome. Here, we show that cancer cells (PSK-1) derived from a patient with Klinefelter syndrome (47XXY) showing loss of an inactive X chromosome subsequently gained active X chromosomes. We found that this abnormal X chromosome composition in PSK-1 is caused by a loss of an inactive X chromosome followed by multiplication of identical active X chromosomes, not by reactivation of an inactive X chromosome. Furthermore, we extended the characterization of loss-of-inactive X in a series of 22 female-derived cancer cell lines (eight breast cancer cell lines, seven ovarian cancer cell lines, and seven cervical cancer cell lines). The data demonstrate that lossof-inactive X in the female-derived cancer cells is mainly achieved by loss of an inactive X chromosomes followed by multiplication of an identical active X chromosomes. However, distinctive pathways, including reactivation of an inactive X chromosome, are also involved in the mechanisms for loss-of-inactive X and gain-of-active X in female-derived cancer cells. The biological significance of the loss-of-inactive X and gain-of-active X in the oncogenesis of Klinefelter syndrome and female-derived cancer cells are discussed.

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“…These clusters were listed as follows: DXS10135-DXS8378-DXS10148, DXS7132-DXS10074-DXS 10075-DXS10079, DXS10103-DXS10101-HPRTB, DXS10134-DXS7423, DXS10159-DXS10162-DXS 10164, DXS6809-DXS6789, and DXS7424-DXS101. The first four clusters were obtained from a database (http://xdb.qualitype.de/xdb/linkageTable.jsf), and the remaining clusters from previous studies (Edelmann et al, 2002;Szibor et al, 2005). Haplotype frequencies for the seven clusters in 94 male samples are displayed in the Table S1.…”

Section: Haplotype Diversitiesmentioning

confidence: 99%

Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese Uygur ethnic minority

Guo

Chen

Wang

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:The population genetic data and forensic parameters of 19 X-chromosome short tandem repeat (X-STR) loci in Chinese Uygur ethnic minority are presented. These loci were detected in a sample of 233 (94 males and 139 females) unrelated healthy individuals. We observed 238 alleles at the 19 X-STR loci, with the corresponding gene frequencies spanning the range from 0.0021 to 0.5644. After Bonferroni correction (P>0.0026), there were no significant deviations from Hardy-Weinberg equilibrium. The cumulative power of discrimination in females and males, and the probability of exclusion of the 19 X-STR loci were 0. 999 999 999 999 999 999 998

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Validation of the STR DXS7424 and the linkage situation on the X-chromosome

Cited by 91 publications

References 19 publications

Collaborative genetic mapping of 12 forensic short tandem repeat (STR) loci on the human X chromosome

Collaborative genetic mapping of 12 forensic short tandem repeat (STR) loci on the human X chromosome

Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells

Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese Uygur ethnic minority

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