Validation of the use of homogeneous reference phantoms for optical tomography of the neonatal brain

Yusof, Rozarina Md.; Hebden, Jeremy C.; Gibson, Adam; Everdell, Nick; Austin, Topun; Meek, Judith; Arridge, Simon; Wyatt, John; Delpy, David T.

doi:10.1117/12.478137

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…This solution was performed with success in vivo on the head of newborn infants [3]. Another solution is to use a reference phantom to calibrate the IRF, so as to work with relative and not absolute datatypes [20]. This solution has two requirements: the reference phantom should have the same geometry as the object to study but it should also have the same optical properties as its background so that the use of relative datatypes is allowed.…”

Section: Reconstruction Methodsmentioning

confidence: 99%

Time-domain reflectance diffuse optical tomography with Mellin-Laplace transform for experimental detection and depth localization of a single absorbing inclusion

Puszka¹,

Hervé²,

Planat-Chrétien³

et al. 2013

Biomed. Opt. Express

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We show how to apply the Mellin-Laplace transform to process time-resolved reflectance measurements for diffuse optical tomography. We illustrate this method on simulated signals incorporating the main sources of experimental noise and suggest how to fine-tune the method in order to detect the deepest absorbing inclusions and optimize their localization in depth, depending on the dynamic range of the measurement. To finish, we apply this method to measurements acquired with a setup including a femtosecond laser, photomultipliers and a time-correlated single photon counting board. Simulations and experiments are illustrated for a probe featuring the interfiber distance of 1.5 cm and show the potential of time-resolved techniques for imaging absorption contrast in depth with this geometry.

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Section: Reconstruction Methodsmentioning

confidence: 99%

Time-domain reflectance diffuse optical tomography with Mellin-Laplace transform for experimental detection and depth localization of a single absorbing inclusion

Puszka¹,

Hervé²,

Planat-Chrétien³

et al. 2013

Biomed. Opt. Express

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“…The balloon is attached via plastic tubing to a reservoir containing the scattering fluid, with valves and a 60 ml syringe in the circuit to facilitate filling and emptying of the balloon. Validation of this technique has been performed using appropriate phantom experiments (Yusof et al 2003). The disadvantage of this approach is the tendency of the near-spherical balloon not to deform sufficiently to the shape of the helmet when placed within it.…”

Section: Difference Imagingmentioning

confidence: 99%

Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

et al. 2006

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Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired from 14 out of 24 infants studied; successful images have been reconstructed in 8 of these infants. Regional variations in cerebral blood volume and tissue oxygen saturation are present in healthy preterm infants. In an infant with a large unilateral intraventricular haemorrhage, a corresponding region of low oxygen saturation was detected. These results suggest that optical tomography may provide an appropriate technique for investigating regional cerebral haemodynamics and oxygenation at the cotside.

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“…Later, optical topography was employed to produce 2D images of activated regions on the surface of the brain [114][115][116][117][118]. To identify changes occurring in deeper tissues, tomographic methods have been studied to produce 3D volumetric images of the whole neonatal brain [119][120][121][122][123].…”

Section: Infant Brain Imagingmentioning

confidence: 99%

In Vivo Diffuse Optical Tomography and Fluorescence Molecular Tomography

Zhang

Bai

2010

Journal of Healthcare Engineering

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Diffuse optical tomography (DOT) and fluorescence molecular tomography (FMT) are two attractive imaging techniques for in vivo physiological and psychological research. They have distinct advantages such as non-invasiveness, non-ionizing radiation, high sensitivity and longitudinal monitoring. This paper reviews the key components of DOT and FMT. Light propagation model, mathematical reconstruction algorithm, imaging instrumentation and medical applications are included. Future challenges and perspective on optical tomography are discussed.

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Validation of the use of homogeneous reference phantoms for optical tomography of the neonatal brain

Cited by 3 publications

References 13 publications

Time-domain reflectance diffuse optical tomography with Mellin-Laplace transform for experimental detection and depth localization of a single absorbing inclusion

Time-domain reflectance diffuse optical tomography with Mellin-Laplace transform for experimental detection and depth localization of a single absorbing inclusion

Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

In Vivo Diffuse Optical Tomography and Fluorescence Molecular Tomography

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