Validation of TrichoScan® technology as a fully-automated tool for evaluation of hair growth parameters

A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1% on hair growth and pigmentation in healthy volunteers with androgenetic alopecia

“…The results may not be directly comparable with studies where methods without dye enhancement (eg, phototrichogram) were used. However, validation studies have shown the good reliability of TrichoScan (Tricholog GmbH), 19 which, together with other dye-enhanced phototrichograms (eg, Canfield technology) are used as gold standard for hair studies and have replaced other techniques. 25,26 Despite the limitations, this study provides important information about the positive effects of latanoprost on hair growth, and might support the approach to use prostaglandin analogues as a new class of molecules for recruitment of vellus hair follicles and improvement of alopecia.…”

“…The sites are cleaned with an alcoholic solution and photographed again. The technique is easy to perform, highly validated, [19][20][21] noninvasive, and with the exception of the tattoo marking the site, causes no discomfort to the patient. 22 Measurements were performed on day 1 (hair diameter) and day 4 (hair density and anagen/telogen ratio) of each assessment period.…”

The Female Pattern Hair Loss: Review of Etiopathogenesis and Diagnosis

“…To ensure reproducibility tattoos identifying the studied area are required [48]. When available, those techniques are helpful for long-term followup and quantification, but currently they are mainly used as a tool for clinical studies [57]. …”

Techniques for the discovery and evaluation of drugs against alopecia

“…Therefore, the computerized phototrichogram techniques need to be improved for more precise assessment of hair growth if they are to be used for clinical trials to compare efficacy for approval. Moreover, the technique requires adequate investigator training and stringent quality control of incoming images [38].…”

“…It was reported that embryonic skin of mammals, when grown in vitro can retain the ability to form hair [12,40]. More recently, mature whole skin from mice and humans has been used to study the hair cycle [37][38][39]. Both white and black mouse skin had been cultured with hair growing for periods of at least 10 --16 days, as well as human scalp tissue with hair follicle cells proliferating for at least 40 days.…”