Validation of visual instrument for location and measurement of pain intensity

Abstract

BACKGROUND AND OBJECTIVES: Inflammation is a defense response of the body to a cellular damage caused by physical, chemical or biological agents, which triggers, among other factors, pain. Although inflammation plays an important role in the protection and regeneration of tissue injury, inflammatory pain results in decreased quality of life. In view of this, the development of safe and less invasive forms for the treatment of inflammatory pain is of great importance. The objective of this study was to evaluate the antihyperalgesic potential of the culture supernatant of keratinocytes and human fibroblasts in an experimental model of inflammatory hyperalgesia. METHODS: Evaluation of carrageenan induced inflammatory hyperalgesia through the use of electronic von Frey in animal models treated with culture supernatant of keratinocytes and fibroblasts. RESULTS: Local administration of naloxone, a nonselective opioid antagonist, in peripheral tissue, has been observed to inhibit the antihyperalgesic effect of the keratinocyte culture supernatant. Fibroblast culture supernatant on days 1 and 3 reverses for 2 hours the carrageenan induced inflammatory hyperalgesia, which is mediated by µ opioid agonist. CONCLUSION: This study indicates that culture supernatant of fibroblasts and keratinocytes is capable of inducing antinociception in inflammatory hyperalgesia, mediated by the release of Evaluation of the keratinocytes or fibroblasts culture supernatant in an inflammatory hyperalgesia model Avaliação do sobrenadante da cultura de queratinócitos ou fibroblastos em modelo de hiperalgesia inflamatória

Self‐reported bio‐psycho‐social factors partially distinguish rotator cuff tendinopathy from other shoulder problems and explain shoulder severity: A case‐control study

“…The eHealth Literacy Scale (eHEALS) was used to evaluate participants' confidence and ability to use electronic health resources for health problems (Norman & Skinner, 2006). Participants drew their pain on body diagram using Navigate Pain (Aalborg University, Denmark) (Supplement 5), previously shown to be valid and useful to improve clinicians' understanding as well as aiding diagnostic decisions (Bayam et al, 2017;Oliveira et al, 2020;Shaballout et al, 2019).…”

Acupuncture in the Management of Lower Pain in Professionals at a Public Hospital Using Distal Points

“…To measure pain during consultations, there are some instruments that can be used, such as the Visual Numerical Scale (VNS), the Visual Analogue Scale (VAS), Verbal Scale (VE), Face Scale (EF), which are classified as unidimensional. (OLIVEIRA et al, 2020). The EVN is a safe, simple, easy to understand and quick to apply scale.…”