Validation study and population data of 15 “new” STR loci: A highly discriminating set for paternity and kinship analysis

Grubwieser, Petra; Zimmermann, Bettina; Niederstätter, Harald; Pavlic, Marion; Parson, Walther

doi:10.1016/j.ics.2005.09.028

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Genomic details of novel autosomal STRs, developed in published multiplexes for CE genotyping[15,[21][22][23][24][25], but not in commercially available kits.…”

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confidence: 99%

A genomic audit of newly-adopted autosomal STRs for forensic identification

Phillips

2017

Forensic Science International: Genetics

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In preparation for the growing use of massively parallel sequencing (MPS) technology to genotype forensic STRs, a comprehensive genomic audit of 73 STRs was made in 2016 [Parson et al., Forensic Sci. Int. Genet. 22, 54-63]. The loci examined included miniSTRs that were not in widespread use, but had been incorporated into MPS kits or were under consideration for this purpose. The current study expands the genomic analysis of autosomal STRs that are not commonly used, to include the full set of developed miniSTRs and an additional 24 STRs, most of which have been recently included in several supplementary forensic multiplex kits for capillary electrophoresis. The genomic audit of these 47 newly-adopted STRs examined the linkage status of new loci on the same chromosome as established forensic STRs; analyzed world-wide population variation of the newly-adopted STRs using published data; assessed their forensic informativeness; and compiled the sequence characteristics, repeat structures and flanking regions of each STR. A further 44 autosomal STRs developed for forensic analyses but not incorporated into commercial kits, are also briefly described.

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“…Genomic details of novel autosomal STRs, developed in published multiplexes for CE genotyping[15,[21][22][23][24][25], but not in commercially available kits.…”

mentioning

confidence: 99%

A genomic audit of newly-adopted autosomal STRs for forensic identification

Phillips

2017

Forensic Science International: Genetics

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“…There are other commercial kits that provide some additional autosomal loci. Conversely in‐house panels of extra autosomal loci can be used but may not be readily available to many laboratories; in the United States, most laboratories are restricted to the use of commercial kits because of intellectual property aspects and because of validation considerations, whereas the situation in Europe and the Far East is more flexible so this option is used 15‐17 . Even so, if these additional loci include any that reside on the same chromosomes as do those markers used in commercial validated kits, then these should be formally shown to be independent of the kit loci; it is unlikely that laboratories are prepared to generate the data for such linkage studies.…”

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confidence: 99%

Use of X‐linked short tandem repeat loci in routine parentage casework

et al. 2007

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In recent times the study of X chromosome haplotypes has been shown to be useful in parentage testing where the alleged father is absent and where only his close relatives are available for testing. This work demonstrates that such studies can also prove valuable in the testing of standard trios and duos in cases where there only a few genetic inconsistencies amongst the loci tested, making it difficult to distinguish between paternal mutations and a close relative of the alleged father being the biologic father.

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Short Tandem Repeats

Bright

2009

Wiley Encyclopedia of Forensic Science

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Short tandem repeat (STR) analysis is the method used in many forensic biology testing laboratories throughout the world for identity and paternity testing. The short length of STRs, their variability between different individuals, and their ability to be amplified via the polymerase chain reaction make them extremely useful as forensic DNA markers. The topics discussed in this entry include nomenclature, common STR loci, multiplexed STRs, variants and mutation rates, and nonhuman analysis of STRs for forensic use.

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Validation study and population data of 15 “new” STR loci: A highly discriminating set for paternity and kinship analysis

Cited by 4 publications

References 15 publications

A genomic audit of newly-adopted autosomal STRs for forensic identification

A genomic audit of newly-adopted autosomal STRs for forensic identification

Use of X‐linked short tandem repeat loci in routine parentage casework

Short Tandem Repeats

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