Validation Thin Layer Chromatography for the Determination of Naproxen in Tablets and Comparison With a Pharmacopeil Method

Validation Thin Layer Chromatography for the Determination of Acetaminophen in Tablets and Comparison with a Pharmacopeial Method

“…Based on the results of the robustness test (Table 2, experimental design matrix (2 3 ) for robustness), which were determined according to the guidelines described in the papers by Nagy-Turák and Ferenczi-Fodor et al, it was stated that the proposed TLC-densitometric method can be regarded as robust. Moreover, it can be suggested that the modification of robustness test procedure in comparison to the methodology presented by Nagy-Turák and Ferenczi-Fodor et al [35, 37] and to our previous investigations [39–43] is suitable for robustness study of TLC-densitometric method used in acetaminophen determination in combined pharmaceutical dosage form. …”

“…These results show that no factor has significant effect on the results. These results were also evaluated by half-normal probability plotting of rank probabilities ( p i ) as a function of the absolute values of the main effects [35, 38, 39]. For example, the effects of factors and half-normal probability plot of effects for the determination of acetaminophen in Product 2 are presented in Figure 5.…”

“…The levels of factors investigated and the experimental design matrix (2 3 ) are shown in Tables 1 and 2, respectively. The ways of calculation of the effects ( E ) characterizing the particular individual factors and rank probabilities [38] were early presented [35, 37, 39–43]. …”

Preparation and study of a naproxen ion-selective electrode

“…They include chromatographic method: HPLC [6], TLC with densitometry [7], gas chromatography-mass spectrometry [8], capillary electrophoresis [9], spectrophotometry [10], spectrofluorymetry [11], chemiluminescence [12], potentiometric titration [13] and other electrochemical methods [14]. These methods are characterized by long and complicated preparation of a sample for analysis as well as expensive instrumental apparatus.…”

Conductometric determination of naproxen in bulk and pharmaceutical dosage form

“…It also inhibits the enzyme thromboxane synthase causing inhibition of the platelet aggregation process [4]. Naproxen is determined in bulk and pharmaceutical dosage forms by UV spectrophotometric techniques [5,6], TLC [7], HPLC with UV detection methods [8], GC-MS [9], ionselective methods [10], phosphorescence and chemiluminescence methods [11], spectrofluorimetric techniques [12][13][14] and capillary electrophoresis with mass detectors [15][16][17]. Bio-analytical methods for detection of naproxen and its metabolites have also been reported [8].…”