“…The RRs were adjusted for age (as a continuous variable), sex, area (Hokkaido and Tohoku, Kanto, Chubu, Kinki, Chugoku, or Kyushu), educational level (attended school until the age of V15, 16-18, or z19 years), family history of colorectal cancer in parents and/or siblings (yes or no), alcohol consumption [never drink, ex-drinkers, or current drinkers who consume <2 or z2 Japanese drinks (<46 g or z46 g of ethanol) per day for men, and never drink, ex-drinkers, or current drinkers for women], smoking (never smoke, ex-smokers, or current smokers), BMI (<20.0, 20.0-24.9, or z25.0 kg/m 2 ), daily walking habits (V30 or >30 min/day), exercise (seldom or never, or 1-2, 3-4, or z5 h a week), sedentary work (yes or no), consumption of beef (almost never, 1-2 times a month, 1-2 times a week, z3 times a week) and pork (almost never, 1-2 times a month, 1-2 times a week, z3 times a week), energy intake (as a continuous variable), and energy-adjusted intakes of folate, calcium, and vitamin D (sex-specific quartile for each). We considered walking time because that was the major physical activity in the study population (43). The RRs and 95% CIs were also computed for colon, rectal, and colorectal cancer among men, women, and both sexes combined.…”