The aim of this study was to clarify the attitudes of nurses working in medical facilities towards family nursing and the related factors. A quantitative cross-sectional design was used. The study period was from December 2017 to February 2018. 638 nurses with more than 5 years clinical experience were recruited from seven medical facilities. The questionnaire included the Families' Importance in Nursing Care-Nurses' Attitudes (FINC-NA), the Family Sense of Coherence (FSOC), and items on nursing practice ability, job satisfaction, and background characteristics. A multiple regression analysis with FINC-NA as the dependent variable and a path analysis of nursing practice ability as the dependent variable were performed. Responses from 416 nurses (effective response rate, 65.2%) were analyzed. Variables that were significantly related to FINC-NA (p < 0.05) were nursing practice ability, FSOC, job satisfaction, family nursing learning experience, presence of a partner and experience in family nursing. Multiple regression analysis with FINC-NA as the dependent variable revealed significant regression coefficients for nursing practice ability, FSOC and job satisfaction.