Validity of Serum Cystatin C for Prediecting Obesity Nephropathy

Asefy, Zahra; Amirrasouli, Hooshang; Khoyi, Masood; Hashemi, Vida

doi:10.4051/ibc.2012.4.2.0004

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Vida Hashemi et al. reported that, while serum creatinine and GFR did not alter significantly, the level of cystatin C increased in obese group when compared lean subjects [ 49 ]. In our study, although the levels of serum creatinine and creatinine-based eGFR which is calculated by Schwartz formula [ 15 ] were not significantly different, cystatin C level was significantly higher in the obese group when compared to the non-obese group.…”

Section: Discussionmentioning

confidence: 99%

Are there any new reliable markers to detect renal injury in obese children?

et al. 2018

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Aim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children.Methods: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were measured, and homeostasis model assessment -insulin resistance (HOMA-IR) was calculated. The urine albumin/creatinine ratio was calculated. The serum and urine KIM-1, NGAL, OPN, and MMP-9 levels were measured.Results: Serum cystatin-C, triglyceride, and homeostasis model assessment-insulin resistance (HOMA-IR) index were found to be significantly higher in the obese group (p = .0001), and high-density lipoprotein (HDL) cholesterol was found to be significantly lower (p = .019) in the obese group. No significant differences were found in serum KIM-1, NGAL, OPN or MMP-9 levels between groups (p > .05). No significant differences were found in urine KIM-1 and MMP-9 levels (p > .05), Urine NGAL, and OPN levels were found significantly higher in obese groups (p < .05).Conclusions: According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population.

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Section: Discussionmentioning

confidence: 99%

Are there any new reliable markers to detect renal injury in obese children?

et al. 2018

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Cystatin C in Patients of Metabolic Syndrome and its Correlation with the Individual Components of Metabolic Syndrome

Aghade¹,

Bavikar²,

Kadam³

et al. 2019

Indian Journal of Medical Biochemistry

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Aim:To determine serum cystatin C (CysC) levels in metabolic syndrome (MetS )patients and correlation of cystatin C with individual components of MetS. Materials methods: A cross-sectional study included 100 cases of MetS and 50 controls. One hundred cases were further divided into 3 groups depending upon the number of components of MetS. Anthropometric parameters like height, weight, BMI (body mass index), Waist circumference were measured. Fasting plasma glucose,serum total cholesterol, serum triglycerides, serum HDL (high density lipoprotein), LDL(low density lipoprotein), VLDL (very low density lipoprotein), systolic blood pressure (SBP) and diastolic blood pressure(DBP), creatinine, urea, eGFR (estimated glomerular filtration rate) and CysC were measured in each individual. Correlation of CysC with each component of Mets was studied. Results: CysC was significantly increased in MetS patients than in controls. Level of serum CysC was increased with an increase in components of MetS. CysC was positively correlated with waist circumference, fasting plasma glucose, triglycerides, SBP, and DBP and negatively correlated with HDL. There was no significant difference in urea, creatinine, and eGFR in studied groups. Conclusion: CysC is significantly correlated with individual components of MetS.CysC may be used as an early marker of renal dysfunction in MetS patients.

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Validity of Serum Cystatin C for Prediecting Obesity Nephropathy

Cited by 2 publications

References 21 publications

Are there any new reliable markers to detect renal injury in obese children?

Are there any new reliable markers to detect renal injury in obese children?

Cystatin C in Patients of Metabolic Syndrome and its Correlation with the Individual Components of Metabolic Syndrome

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