Valoración geriátrica y factores asociados a mortalidad en ancianos con insuficiencia cardíaca ingresados en una unidad de geriatría de agudos

Roig, T Gurrera; Márquez, Miguel Ángel; Hernández, Esmeralda; Pineda, Ingrid; Sabartés, Olga; Miralles, Ramón; Inzitari, Marco

doi:10.1016/j.regg.2013.07.001

Cited by 12 publications

(4 citation statements)

References 16 publications

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“…The wide application of these drugs helps significantly decrease the fatality rate and hospitalization rate of heart failure. But the morbidity and mortality of heart failure are still high, which are still the main causes of disability and death of cardiovascular diseases, seriously threatening human health (6,7). Therefore, research on new anti-heart failure drugs is still in the ascendant.…”

Section: Introductionmentioning

confidence: 99%

Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats

et al. 2018

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The effects of berberine on cardiac function of heart failure after myocardial infarction and its possible mechanism were investigated. The anterior descending branches of 50 female Wistar rats were ligatured to establish the model of heart failure after myocardial infarction. At 4 weeks after successful modeling, the rats were randomly divided into two groups receiving 4-week gavage with saline (Sal group) and berberine (Ber group), while the sham-operation group (Sham group) was set up. After 4 weeks, the hemodynamics and serum BNP in rats were measured. The hearts of rats were taken to detect the degree of myocardial fibrosis. The myocardial cell apoptosis was detected. The expressions and changes in myocardial apoptosis-related proteins, including Bcl-2, Bax and caspase-3, were detected. The expression and changes in GRP78, CHOP and caspase-12 in myocardial tissue were detected. The results showed that Berberine improved the cardiac function of rats after myocardial infarction. After myocardial infarction, myocardial fibrosis and apoptosis were observed around the infarction area, berberine improved the myocardial fibrosis and reduced cell apoptosis. Furthermore, berberine alleviated endoplasmic reticulum stress (ERS) after myocardial infarction. In conclusion, Berberine can inhibit the myocardium cell apoptosis of heart failure after myocardial infarction, and its mechanism may be realized by affecting the ERS in myocardial tissue of heart failure after myocardial infarction and CHOP and caspase-12 apoptotic signaling pathway, upregulating Bcl-2/Bax expression and downregulating caspase-3 expression, thus inhibiting the cardiac remodeling and protecting the cardiac function.

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Section: Introductionmentioning

confidence: 99%

Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats

et al. 2018

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“…However, the most remarkable difference between older and young patients is the possibility of functional impairment (sometimes reversible) and the lower capacity to react to stressors (frailty) [ 13 ]. Frailty, which is present in up to 44% of patients with HF [ 14 , 15 ], is independently associated with higher mortality [ 14 , 15 , 16 , 17 , 18 ] and poorer quality of life [ 19 ]. A comprehensive geriatric assessment is a multidimensional and interdisciplinary diagnostic process used to evaluate frail older adults’ medical, psychological, functional, and social aspects to develop a coordinated, individualized, and comprehensive treatment and long-term follow-up plan.…”

Section: Introductionmentioning

confidence: 99%

Randomized Controlled Trial Comparing a Multidisciplinary Intervention by a Geriatrician and a Cardiologist to Usual Care after a Heart Failure Hospitalization in Older Patients: The SENECOR Study

Herrero-Torrus

Badosa

Roqueta

et al. 2022

JCM

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Background: The prognosis of older patients after a heart failure (HF) hospitalization is poor. Methods: In this randomized trial, we consecutively assigned 150 patients 75 years old or older with a recent heart failure hospitalization to follow-up by a cardiologist (control) or follow-up by a cardiologist and a geriatrician (intervention). The primary outcome was all-cause hospitalization at a one-year follow-up. Results: All-cause hospitalization occurred in 47 of 75 patients (62.7%) in the intervention group and in 58 of 75 patients (77.3%) in the control group (hazard ratio, 0.67; 95% confidence interval, 0.46 to 0.99; p = 0.046). The number of patients with at least one HF hospitalization was similar in both groups (34.7% in the intervention group vs. 40% in the control group, p = 0.5). There were a total of 236 hospitalizations during the study period. The main reasons for hospitalization were heart failure (38.1%) and infection (14.8%). Mortality was 24.7%. Heart failure was the leading cause of mortality (54.1% of all deaths), without differences between groups. Conclusions: A follow-up by a cardiologist and geriatrician in older patients after an HF hospitalization was superior to a cardiologist’s follow-up in reducing the risks of all-cause hospitalization in older patients. (Funded by Beca Primitivo de la Vega, Fundación MAPFRE. ClinicalTrials.gov number, NCT03555318).

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“…Cualquier decisión terapéutica en pacientes ancianos con enfermedad tumoral debe considerar factores comórbidos y el estado basal del paciente siendo imperativa una evaluación multidisciplinaria por geriatría, oncología y digestivo, individualizando el carácter paliativo en función de cada paciente 3,6,8 .…”

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“…Las complicaciones quirúrgicas fueron grado I sin re-intervenciones excepto un paciente con dehiscencia de estoma (grado IIIb). La cirugía electiva se ha probado recomendable, aumentando la supervivencia 3,8 , por lo que un diagnóstico precoz con planificación previa disminuye la morbimortalidad relacionada a la cirugía. De los 23 pacientes operados se encontraban libres de enfermedad 10, todos intervenidos electivamente.…”

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Características clínicas y supervivencia a 30 días de pacientes ancianos colombianos hospitalizados por insuficiencia cardiaca descompensada

Ocampo-Chaparro¹,

Badiel²,

Casanova³

et al. 2015

Revista Española de Geriatría y Gerontología

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Valoración geriátrica y factores asociados a mortalidad en ancianos con insuficiencia cardíaca ingresados en una unidad de geriatría de agudos

Cited by 12 publications

References 16 publications

Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats

Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats

Randomized Controlled Trial Comparing a Multidisciplinary Intervention by a Geriatrician and a Cardiologist to Usual Care after a Heart Failure Hospitalization in Older Patients: The SENECOR Study

Características clínicas y supervivencia a 30 días de pacientes ancianos colombianos hospitalizados por insuficiencia cardiaca descompensada

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