Valproate, bipolar disorder and polycystic ovarian syndrome

Okanovic, Milana; Zivanovic, O.

doi:10.2298/mpns1604121o

Cited by 12 publications

(13 citation statements)

References 25 publications

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“…While typical side-effects of first-generation antipsychotics such as chlorpromazine and haloperidol were Parkinson's disease-like movements, internal restlessness and tardive dyskinesia, typical sideeffects of the so-called second-generation antipsychotics are on metabolism, leading to weight gain, insulin-resistance (Grajales et al, 2019;Sarsenbayeva et al, 2019;Skonieczna-Żydecka et al, 2019) and extrapyramidal adverse effects (Divac et al, 2014). Given that such sideeffects may have unfavorable effects on patients' medication adherence (Okanović and Živanović, 2016), the search for further treatment options is justified.…”

Section: Introductionmentioning

confidence: 99%

Influence of adjuvant clonidine on mania, sleep disturbances and cognitive performance – Results from a double-blind and placebo-controlled randomized study in individuals with bipolar I disorder during their manic phase

Ahmadpanah

Pezeshki

Soltanian

et al. 2022

Journal of Psychiatric Research

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Section: Introductionmentioning

confidence: 99%

Influence of adjuvant clonidine on mania, sleep disturbances and cognitive performance – Results from a double-blind and placebo-controlled randomized study in individuals with bipolar I disorder during their manic phase

Ahmadpanah

Pezeshki

Soltanian

et al. 2022

Journal of Psychiatric Research

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“…The very beginning of symptoms could have been attributed to psychotic relapse or overdose of psychiatric medications (which was not the first episode of these symptoms in neither of these patients). It has been noticed that both the confusion and delirium-like state are quite common early symptoms of COVID-19 disease [1,2,[4][5][6]. In fact, these symptoms are among the six most common symptoms of SARS-CoV-2 infection [7][8][9][10][11][12][17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…Health workers in primary, secondary and tertiary health care institutions, have learned a lot about clinical features of COVID-19 and a lot of information has been published worldwide [1][2][3]. All the medical staff has become familiar with COVID-19 symptoms, diagnosis and treatment options [4][5][6][7]. However, it is interesting that one common symptom, mental confusion, is underestimated and sometimes hard to recognize, especially in psychiatric patients who were previously psychotic and then were infected with SARS-CoV-2 [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Understanding the state of confusion in patients with psychosis during COVID-2019 pandemic: A report of two cases

Cvjetković-Bošnjak

Bibic²,

Nedic

et al. 2022

Med pregl

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Introduction. There is a lot of evidence that coronavirus disease 2019 has various manifestations. This paper presents a report of two cases with the aim to indicate the multifactorial etiology of confusional states in patients with mental disorders at the time coronavirus disease 2019 pandemic. The severe acute respiratory syndrome coronavirus-2 affects not only the respiratory and cardiovascular systems, but also the brain, kidneys and other organ systems. One of the first manifestations of this infection can be mental confusion. Case Study. The first patient, a woman diagnosed with schizoaffective psychosis, suddenly presented with confusion, followed by hypersedation which was at first attributed to overmedication. In another patient, with the diagnosis of bipolar affective disorder, sudden confusion (delirium) was initially recognized as an element of mental disorder deterioration. A more detailed observation revealed that the confused state in both patients was caused by severe acute respiratory syndrome coronavirus-2 infection. Discussion. It is common for the manifestations of severe acute respiratory syndrome coronavirus-2 infection to include respiratory and cardiovascular syimptoms. However, symptoms related to other organs and organ systems, including changes in neurological and psychological status, should not be ignored. Conclusion. It was noticed that confusion and delirium-like states are quite common early symptoms of coronavirus disease 2019. In psychiatric patients, it is always necessary to rule out the organic etiology of the consciousness disorder and immediately proceed with the diagnostic procedures. One should certainly keep in mind that diagnostic errors are possible, not only due to various manifestations of the infection, but also due to the stigmatization of mental illness, which must be overcome in order to provide the best possible treatment effects.

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“…En aquellas con hiperinsulinismo o diabetes, se siguieron las indicaciones terapéuticas del endocrinólogo. Debido a la asociación descrita entre el uso de ácido valproico y la aparición de ovarios poliquísticos (Genton et al, 2001;O'Donovan, Kusumakar, Graves y Bird, 2002;Okanović yŽivanović, 2016;Rasgon et al, 2005), se consideró este como un criterio de exclusión. Ninguna paciente recibía o había recibido tratamiento con ácido valproico.…”

Section: Instrumentos Y Medidasunclassified

Polycystic ovarian syndrome and its potential association with bipolar disorder in patients with eating disorder

Guarín

Rueda²,

Muñoz³

et al. 2017

Revista Mexicana de Trastornos Alimentarios

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Exploration of polycystic ovarian syndrome (PCOS) in women with eating disorders (ED) is uncommon, and its association with bipolar disorder (BD) has been understudied. The aim of this study was to determine the prevalence of PCOS in women with ED in an outpatient program and to analyze the potential associations with BD. A total of 388 patients (88 with PCOS and 300 without PCOS) aged among 14 to 61 years were included in the study. Pelvic ultrasound, laboratory tests, and physical exams were performed to each participant. Bivariate analyses were carried out between PCOS, BD and other variables such as: psychiatric comorbidities, body mass index and type of ED. An association model was built. PCOS and BD prevalence were 22.7% and 13.1% respectively. The variables associated with PCOS were: BD type II, overweight or obesity and having an ED with binges and/or purges. When obesity and bulimic ED subtypes were controlled, patients with PCOS and BD type have 5.8 times higher risk of BD type II (OR = 5.85; 95% IC = 2.9-11.6). Comorbidities among these three pathologies are frequent, therefore its exploration and management should be considered.

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Valproate, bipolar disorder and polycystic ovarian syndrome

Cited by 12 publications

References 25 publications

Influence of adjuvant clonidine on mania, sleep disturbances and cognitive performance – Results from a double-blind and placebo-controlled randomized study in individuals with bipolar I disorder during their manic phase

Influence of adjuvant clonidine on mania, sleep disturbances and cognitive performance – Results from a double-blind and placebo-controlled randomized study in individuals with bipolar I disorder during their manic phase

Understanding the state of confusion in patients with psychosis during COVID-2019 pandemic: A report of two cases

Polycystic ovarian syndrome and its potential association with bipolar disorder in patients with eating disorder

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