Valsartan plus hydrochlorothiazide: a review of its use since its introduction

Bains, Jujhar; Smith, William B

doi:10.1517/14656566.2011.587124

Cited by 4 publications

(2 citation statements)

References 73 publications

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“…It also compensates the increased plasma renin activity provoked by the diuretic [22,23,24,25]. During the observed period FDCs of sartan and diuretic performed steady increase in their dosage forms, trademarks and new international non-proprietary name (INN).…”

Section: Fig 4 Changes In Reference Price Per Ddd For the Fdcs Of Amentioning

confidence: 99%

Fixed Doses Combinations Acting on Cardiovascular System - Utilization and Generic Competition

Mitkova

Manova²,

Georgieva

et al. 2016

AIR

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2 -inhibitors and diuretics, angiotensin receptor blockers (AT receptor blockers, ARBs, sartans) and diuretics. Many new generic molecules as FDCs enter the PDL, thus leading to decrease in the reference price, because of generic competition. The decrease is significant in the new therapeutic groups. The changes in utilization calculated as defined daily dose (DDD)/1000 inhabitants/day show higher utilization in 2013 for the groups of ACE inhibitors and diuretics and AT receptor blockers and diuretics (Enalapril/ Hydrochlorthiazide (HCTZ), Perindopril/ Indapamide, Valsartan/HCTZ, Losartan/ HCTZ). Conclusion:The study confirms that in Bulgaria the generic and therapeutic competition has increased during 2009-2013. It leads to significant price decrease and changes in the trends in utilization of the FDC in cardiology.

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Section: Fig 4 Changes In Reference Price Per Ddd For the Fdcs Of Amentioning

confidence: 99%

Fixed Doses Combinations Acting on Cardiovascular System - Utilization and Generic Competition

Mitkova

Manova²,

Georgieva

et al. 2016

AIR

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“…5 However, these drugs must be combined with other diuretic drugs such as spironolactone, hydrochlorothiazide, etc. 6,7 The usage of combined drugs was accompanied by long-term use side effects including hypotension, cough, and teratogenicity. 8 In recent years, more and more researchers have focused on the effects of traditional Chinese medicine on CH, and found some potential natural products, such as salidroside, 9 vinca alkaloids, 10 and several other cardiovascular medicines.…”

Section: Introductionmentioning

confidence: 99%

Phillyrin Inhibits Isoproterenol-Induced Cardiac Hypertrophy Via P38 and NF-κB Pathways

Liu

Yang

et al. 2022

Natural Product Communications

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Cardiac hypertrophy (CH) is the main compensatory response to chronic heart stress and often progresses to a decompensation state potentially leading to heart failure. Phillyrin (PHI) is a novel compound derived from Forsythia, which has shown anti-inflammatory and anti-virus activities as well as renal protective effects on diabetic nephropathy. Therefore, we investigated the effects of PHI on CH induced by isoproterenol (ISO). Cardiac hypertrophy was induced by ISO in vivo, and the H9C2 cells were treated with ISO. PHI treatment alleviated CH in isoproterenol-induced mice in 7 and 14 days. Echocardiography showed that the PHI improved ISO-induced CH heart function and structure. PHI significantly decreased heart weight/body weight (HW/BW) and heart weight/tibia length (HW/TL) ratios and improved left ventricular (LV) function in ISO-treated mice. Hematoxylin and eosin staining revealed cardiomyocyte areas of the ISO group were significantly increased, and PHI was significantly reduced at 7 and 14 days, PHI-100 groups showed significantly better improvements than PHI-50. Sirius red staining indicated PHI significantly decreased collagen deposition in heart cross-sections induced by ISO, and PHI repressed ISO-induced cTn-I and NT-proBNP expression in mouse serum. In vitro data from H9C2 cells showed that PHI decreased cell areas and total cell protein levels in cells induced by ISO, whereas ANP, BNP, IL-6, and IL-1β expression was significantly inhibited by PHI. Also, PHI simultaneously inhibited P65 and P38 phosphorylation in vivo and in vitro. In conclusion, this study demonstrated the protective effect of PHI on CH in in vivo and in vitro, and this effect was related to the suppression of inflammation through the activation of the P38/NF-κB pathway.

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Long-term safety of nebivolol and valsartan combination therapy in patients with hypertension: an open-label, single-arm, multicenter study

Neutel

Giles

Punzi

et al. 2014

Journal of the American Society of Hypertension

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Valsartan plus hydrochlorothiazide: a review of its use since its introduction

Cited by 4 publications

References 73 publications

Fixed Doses Combinations Acting on Cardiovascular System - Utilization and Generic Competition

Fixed Doses Combinations Acting on Cardiovascular System - Utilization and Generic Competition

Phillyrin Inhibits Isoproterenol-Induced Cardiac Hypertrophy Via P38 and NF-κB Pathways

Long-term safety of nebivolol and valsartan combination therapy in patients with hypertension: an open-label, single-arm, multicenter study

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