Strychnos spinosa Lam. is among the top nutrient-dense indigenous fruit species that are predominant in Southern Africa. It is a highly ranked indigenous fruit based on the nutrition and sensorial properties, which make it an important food source for the marginalized rural people. On the basis of the high vitamin C, iron, and zinc content, it has the capacity to improve the food- nutrition and the socioeconomic status of individuals, especially those in the rural areas of the developing nations. The nutritional composition of Strychnos spinosa compare favorably with many of the popular fruits, such as strawberries and orange. Additionally, Strychnos spinosa has antioxidant activity similar to well-known antioxidant fruits, which keeps it in the class of the popular fruits, giving it added nutrition–health-promoting benefits. In order to improve the availability of Strychnos spinosa, more research on the domestication, processing, preservation, value chain, and economic potential need to be further explored. Therefore, we recommend more concerted efforts from relevant stakeholders with interest in Strychnos spinosa fruit production as a possible sustainable solution to food shortage, food-nutrition insecurity, malnutrition, and austerity, mainly in the rural communities of the developing countries.