Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy

Lee, Jiyeong; Kim, Chan Kyo; Gu, Kyowon; Park, Won

doi:10.1007/s00330-019-06198-5

Cited by 18 publications

(14 citation statements)

References 27 publications

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“…The current prevention and treatment strategies for cervical cancer only include vaccine prevention, surgery, radiotherapy, chemotherapy, RNA interference therapy, and hormone therapy. Although the cure rate of cervical cancer can reach 80%–90%, its recurrence rate is high, and the local control rate is poor, resulting in a decrease in patient survival rate [ 8 ]. Therefore, it is of great significance to find a safe and effective treatment method to improve the prognosis of cervical cancer patients and increase the survival time after surgery.…”

Section: Discussionmentioning

confidence: 99%

Effect of MiR-375 Regulates YAP1 on the Invasion, Apoptosis, and Epithelial-Mesenchymal Transition of Cervical Cancer HeLa Cells

Huiuk

Luo

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Yes-associated protein 1 (YAP1) is an important signaling pathway activator molecule. Studies have shown that it is involved in the occurrence of malignant tumors. This study identified a microRNA (miR/miRNA) targeting the 3′ untranslated region (3″ utr) of the YAP1 gene and evaluated its biological impact on human cervical cancer cells and related molecular mechanisms. qPCR and western blotting were used to detect the levels of miR-375 and YAP1 in HeLa cells. TargetScan software was used to identify the binding sites of YAP1 and miR-375. The MTT method was used to determine the viability of HeLa cells transfected with miR-375 mimic and YAP1 interference vector, the Transwell chamber experiment was used to detect the invasion of HeLa cells after transfection, the apoptosis of HeLa cells after transfection was detected by flow cytometry, and the western blotting was used to detect the epithelial mesenchymal transition (EMT) of HeLa cells after transfection. The expression of miR-375 in HeLa cells was significantly lower than that of normal control cervical cells, and the expression of YAP1 in HeLa cells was significantly higher than that of normal control cervical cells. TargetScan analysis showed that miR-375 was bound to the 3′ UTR of YAP1. qPCR and western blot analysis showed that transfection of miR-375 mimics inhibited YAP1 expression in HeLa cells. Transfection of miR-375 mimic and YAP1 interference vector inhibited HeLa cell invasion and EMT and promoted HeLa cell apoptosis. These findings indicate that miR-375 inhibits the malignant development of human cervical cancer cells by regulating the expression of YAP1.

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Section: Discussionmentioning

confidence: 99%

Effect of MiR-375 Regulates YAP1 on the Invasion, Apoptosis, and Epithelial-Mesenchymal Transition of Cervical Cancer HeLa Cells

Huiuk

Luo

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Pelvic MRI is the reference examination for the evaluation of cervical cancers, allowing the accurate evaluation of tumor size, parametrial extension, and lymph node metastasis, which are essential factors for therapeutic management [470][471][472][473]. MRI, CT/MRI, and PET/MRI have been used for cervical cancer staging and lymph node metastasis [474,475], and PET/MRI was found to possess a higher diagnostic sensitivity [476], specificity [477], and accuracy [478,479], also during pregnancy [480], being helpful in clinical diagnosis [481], prediction [482], and treatment [483,484]. MRI diagnosis is an auxiliary method for cervical cancer treatment when used in combination with tumor markers (e.g., squamous cell carcinoma antigen) [485] and for the management of women with early cervical cancer [486].…”

Section: Cervical Uterine Cancermentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, at home and at work. Epidemiological studies indicate that there is a positive relationship between residential/domestic and occupational exposure to extremely low frequency electromagnetic fields and some types of cancer, although some other studies indicate no relationship. In this review, after an introduction on the MF definition and a description of natural/anthropogenic sources, the epidemiology of residential/domestic and occupational exposure to MFs and cancer is reviewed, with reference to leukemia, brain, and breast cancer. The in vivo and in vitro effects of MFs on cancer are reviewed considering both human and animal cells, with particular reference to the involvement of reactive oxygen species (ROS). MF application on cancer diagnostic and therapy (theranostic) are also reviewed by describing the use of different magnetic resonance imaging (MRI) applications for the detection of several cancers. Finally, the use of magnetic nanoparticles is described in terms of treatment of cancer by nanomedical applications for the precise delivery of anticancer drugs, nanosurgery by magnetomechanic methods, and selective killing of cancer cells by magnetic hyperthermia. The supplementary tables provide quantitative data and methodologies in epidemiological and cell biology studies. Although scientists do not generally agree that there is a cause-effect relationship between exposure to MF and cancer, MFs might not be the direct cause of cancer but may contribute to produce ROS and generate oxidative stress, which could trigger or enhance the expression of oncogenes.

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“…Using this technique, Baudelet et al (2006) observed signal fluctuations more frequently in tumor regions containing immature blood vessels in fibrosarcoma-bearing mice [412]. BOLD-MRI was used in clinical settings to evaluate response to treatments in recurrent cervical cancer and locally advanced breast cancer [413][414][415]. It was also used to generate oxygen saturation maps in normal and cancer prostate tissues and in patients with infiltrative astrocytoma [415][416][417].…”

Section: Techniques To Map Hypoxic Areas and Immune Infiltrationmentioning

confidence: 99%

Hypoxia and the phenomenon of immune exclusion

Pietrobon

Marincola

2021

J Transl Med

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Over the last few years, cancer immunotherapy experienced tremendous developments and it is nowadays considered a promising strategy against many types of cancer. However, the exclusion of lymphocytes from the tumor nest is a common phenomenon that limits the efficiency of immunotherapy in solid tumors. Despite several mechanisms proposed during the years to explain the immune excluded phenotype, at present, there is no integrated understanding about the role played by different models of immune exclusion in human cancers. Hypoxia is a hallmark of most solid tumors and, being a multifaceted and complex condition, shapes in a unique way the tumor microenvironment, affecting gene transcription and chromatin remodeling. In this review, we speculate about an upstream role for hypoxia as a common biological determinant of immune exclusion in solid tumors. We also discuss the current state of ex vivo and in vivo imaging of hypoxic determinants in relation to T cell distribution that could mechanisms of immune exclusion and discover functional-morphological tumor features that could support clinical monitoring.

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Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy

Cited by 18 publications

References 27 publications

Effect of MiR-375 Regulates YAP1 on the Invasion, Apoptosis, and Epithelial-Mesenchymal Transition of Cervical Cancer HeLa Cells

Effect of MiR-375 Regulates YAP1 on the Invasion, Apoptosis, and Epithelial-Mesenchymal Transition of Cervical Cancer HeLa Cells

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Hypoxia and the phenomenon of immune exclusion

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