Value of Calcium and Phosphorous in chronic kidney disease patients under hemodialysis: A retrospective study

Singh, Samir; Dhungel, Kshitiz Upadhyay; Aryal, Gopi

doi:10.3126/jpn.v2i4.6881

Cited by 6 publications

(7 citation statements)

References 15 publications

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“…hyperphosphatemia in CKD patients Hyperphosphatemia is one of the major factors liable for alterations in mineral and bone metabolism in dialysis patients. These findings are similar to the study done in Iran through Mahdavi-Mazdeh M et al 17 and Singh S et al 13 in Nepal. Hyperphosphatemia results due to reduced phosphorous filtration and excretion with the progression of CKD.…”

Section: Discussionsupporting

confidence: 92%

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Biochemical and hematological parameters in chronic kidney disease

Singh

Bhatta

2018

J. Manmohan Memorial Inst. Health. Sci.

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Background: Chronic kidney disease is a worldwide public health problem. It is associated with various biochemical and hematological abnormalities that leads to morbidity and mortality. The aim of this study was to evaluate the biochemical and hematological parameters in chronic kidney disease patients.Methods: This is a prospective cross sectional study conducted over a period of six months on 52 chronic kidney disease patients at Kist Medical College Teaching Hospital, Lalitpur, Nepal. Biochemical parameters such as urea, creatinine, calcium, phosphorous, sodium, potassium and hematological parameters like hemoglobin, hematocrit, red blood cell count, total leukocyte count, platelet count were measured using standard techniques in chronic kidney disease cases and the findings were compared with age and sex matched controls. Results were analyzed using SPSS 21 for Windows.Results: Hemoglobin, hematocrit, red blood cell count, total leukocyte count and platelet count were reduced and statistically significant in chronic kidney disease patients compared to controls(p <0.05).In biochemical parameters, serum urea, creatinine, phosphorous were increased and calcium was reduced which was found statistically significant as compared to controls (p <0.05). The combination of diabetes and hypertension was the lead cause of chronic kidney disease found in 38.46% followed by hypertension alone in 30.76%Conclusion: Biochemical and hematological parameters are deranged in patients with chronic kidney disease. Routine evaluation of these parameters is useful in the management of these patients.

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Section: Discussionsupporting

confidence: 92%

“…So, mineral metabolism results are gaining significance in hemodialysis treatment. 13 In our study, the mean serum calcium in CKD subjects was 8.03±0.80 and in controls was 9.06±0.54 with p value < 0.001 which was statistically significant. Majority of our study subjects were hypocalcemic.…”

Section: Discussionsupporting

confidence: 49%

Biochemical and hematological parameters in chronic kidney disease

Singh

Bhatta

2018

J. Manmohan Memorial Inst. Health. Sci.

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“…16 Abnormal mineral metabolism starts early in the course of CKD and ESRD, and is usually accompanied by profound changes such as bone disease, musculoskeletal symptoms and growth retardation. 17 The pathophysiology of both idiopathic and secondary RLS is still a subject of discussion. A limited number of studies have been conducted to find out the pathophysiology of RLS in uremic patients.…”

Section: Discussionmentioning

confidence: 99%

Association of Bone Mineral Profile With Restless Leg Syndrome in Patients With End Stage Renal Disease.

Sultan

Nasir

Qureshi

et al. 2022

J Ayub Med Coll Abbottabad

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Background: Restless leg syndrome (RLS) is one of the problem hemodialysis patients may encounter. This study was done to find out the association of restless legs syndrome (RLS) in end stage renal disease patients with serum calcium, phosphorus and parathyroid hormone levels. Methods: This cross-sectional observational study was done at The Kidney Centre, postgraduate Training Institute Karachi, Pakistan from Jan to June 2020. One hundred and twelve patients on three per week hemodialysis for more than three months at our hemodialysis centre were face to face interviewed as per International Restless Legs Syndrome Study Group criteria (IRLSSG) for the presence of RLS symptoms. Their demographic data and laboratory values were recorded from history chart and computer records. The bone mineral profile in this study includes serum calcium (corrected for albumin), serum phosphate levels and serum intact Parathyroid hormone (iPTH) levels. Statistical analyses were done by using SPSS-21. Results: In our study, 38.4% patients had RLS. Serum phosphorus levels were significantly higher in patients with RLS as compared to those who didn’t have RLS. No significant association of serum calcium and Parathyroid hormone (PTH) levels with RLS was found. Conclusion: There is a high prevalence of RLS in ESRD patients as compared to general population. Serum phosphorus levels need to be observed and corrected along with maintenance of calcium and PTH levels to improve symptoms of RLS in these patients.

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“…The disturbances embrace calcium, phosphorous, vitamin D, and PTH homeostasis. So, mineral metabolism results are gaining significance in hemodialysis treatment (Singh S. et al 2012). On the other hand, similar results to ours are mentioned in other studies from RusulArif 2018 and Freethi et al 2016, where significant hypocalcemia is observed in CKD patients.…”

Section: Figure 2 Etiology Of Chronic Kidney Diseasementioning

confidence: 99%

Biochemical and Hematological Parameters in a Group of Chronic Kidney Disease Patients in Albania

Rumano¹,

Elezi²,

Rumano³

2021

EPHELS

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Chronic kidney disease is a serious, life threating health problem. It is also known as chronic kidney failure, as it is a process of irreversible loss of nephrons, which at the end stage leads to kidney failure. There are many different reasons that lead to kidney failure, such as: hypertension, diabetes, polycystic kidney disease, glomerulonephritis, parathyroid glands dysfunction, etc. The aim of this study was to evaluate the biochemical and hematological profile in a group of chronic kidney patients in Albania. A group of 247 chronic kidney disease patients is included in this study (170 adult males and 77 adult females). A group of biochemical parameters, such as urea, CRP, albuminemia, HbA1C, creatinine, ALT, AST, calcium, phosphate, CaxP product, sodium, potassium and hematological parameters, such as hemoglobin, red blood cells, white blood cells and PTH, where measured and compared to the findings from the control group. Results were analyzed statistically using SPSS 20 program for windows. From data analysis, we found a reduced count of red blood cells and hemoglobin, statistically significant change, compared to the control group (p0.05). High levels of PTH, serum urea, creatinine and hyperphosphatemia, accompanied by hypocalcemia, were found statistically significant compared to the control group (p0.05). From our observations, hypertension, diabetes and kidney stones were the main causes leading to chronic kidney disease. Evaluation of these parameters, results to be significant in the differentiation and management of the health state of these patients.

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Value of Calcium and Phosphorous in chronic kidney disease patients under hemodialysis: A retrospective study

Cited by 6 publications

References 15 publications

Biochemical and hematological parameters in chronic kidney disease

Biochemical and hematological parameters in chronic kidney disease

Association of Bone Mineral Profile With Restless Leg Syndrome in Patients With End Stage Renal Disease.

Biochemical and Hematological Parameters in a Group of Chronic Kidney Disease Patients in Albania

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