Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM)

Mikołajczyk, Mateusz; Wirstlein, Przemysław; Adamczyk, Magdalena; Skrzypczak, Jana; Wender-Ożegowska, Ewa

doi:10.1515/jpm-2019-0280

Cited by 10 publications

(15 citation statements)

References 28 publications

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“…Preterm prelabor rupture of membranes (PROM) is widely used as an inclusion criterion for predictions of other conditions. [1][2][3][4][5][6][7][8] The disease precedes 40%~50% of all preterm deliveries and arises from multiple disease pathways. 9 Yet, the antecedent remains unclear, and prognostic predictions lack proper sample sizes and external validation.…”

Section: Introductionmentioning

confidence: 99%

Prognostication for prelabor rupture of membranes and the time of delivery in nationwide insured women: development, validation, and deployment

Sufriyana

Wu²,

Ec³

2021

Preprint

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Prognostic prediction of prelabor rupture of membrane (PROM) lacks of sample size and external validation. We compared a statistical model, machine learning algorithms, and a deep-insight visible neural network (DI-VNN) for PROM and estimating the time of delivery. We selected visits, including PROM (n=23,791/170,730), retrospectively from a nationwide health insurance dataset. DI-VNN achieved the best prediction (area under receiver operating characteristics curve [AUROC] 0.73, 95% CI 0.72 to 0.75). Meanwhile, random forest using principal components achieved the best estimation with root mean squared errors ± 2.2 and 2.6 weeks respectively for the predicted event and nonevent. DI-VNN outperformed previous models by an external validation set, including one using a biomarker (AUROC 0.641; n=1,177). We deployed our models as a web application requiring diagnosis/procedure codes and dates. In conclusion, our models may be used solely in low-resource settings or as a preliminary model to reduce a specific test requiring high-resource setting.

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Section: Introductionmentioning

confidence: 99%

Prognostication for prelabor rupture of membranes and the time of delivery in nationwide insured women: development, validation, and deployment

Sufriyana

Wu²,

Ec³

2021

Preprint

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“…Early and correct diagnosis of HCA is important; however, the event restricts that placental pathology can be evaluated only after delivery. The inflammatory response can also be shown in the fetal amniotic fluid, maternal cervicovaginal fluid, and systemically maternal and fetal serum in the PPROM setting [14,15]. Previous evidence indicates that HCA is associated with increased maternal and fetal serum levels of pro-inflammatory cytokines, including interleukin-1 beta (IL-1β), IL-6, IL-8, IL-10, IL-22, and tumor necrosis factor-alpha (TNF-α) [16].…”

Section: Introductionmentioning

confidence: 99%

The Implication of Aquaporin-9 in the Pathogenesis of Preterm Premature Rupture of Membranes

Ölmez

Oğlak

Can

2022

Z Geburtshilfe Neonatol

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Objective This study aimed to detect aquaporin-9 (AQP9) concentrations in the serum of patients with preterm premature rupture of membranes (PPROM) and compare them with the healthy control group with intact membranes. Material and methods We conducted this prospective case-control study from January 2020 to June 2020. Of the 80 pregnant patients included in the study, we enrolled 42 singleton pregnant patients with PPROM as the study group and 43 healthy gestational age-, and body mass index (BMI)-matched healthy pregnant women with intact fetal membranes as the control group. We compared demographic and clinical characteristics, complete blood count and biochemical parameters, and serum AQP9 concentrations of the participants. We constructed an ROC curve to illustrate the sensitivity and specificity performance characteristics of AQP9 and calculated a cutoff value by using the Youden index. Results Maternal serum AQP-9 concentrations were significantly higher in patients with PPROM (804.46±195.63 pg/mL) compared to the healthy pregnant women in the control group (505.97±68.89 pg/mL, p<0.001). When we examine the area under the ROC curve (AUC), the AQP-9 value can be reflected as a statistically significant parameter for diagnosing PPROM. According to the Youden index, a 654.78 pg/mL cut-off value of AQP-9 can be utilized to diagnose PPROM with 80.5% sensitivity and 100% specificity. Conclusion Maternal serum AQP9 concentrations were significantly higher in PPROM patients than healthy pregnant women with an intact membrane. We suggest that AQP9 might be an essential biomarker of the inflammatory process and energy homeostasis in PPROM.

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“…Umbilikal kordon kanında CRP yüksekliğinin ya da amniyon sıvısında artmış nötrofil sayısının saptanması da (amniyotik sıvıdaki nötrofiller fetüs orijinli) FIRS tanımında destekleyici bulunmuştur. [45][46][47][48] FIRS, erişkinlerdeki sistemik inflamatuar yanıt sendromu [systemic inflammatory response syndrome (SIRS)]nun fetal karşılığı olarak kabul edilmekte, ancak SIRS tanımlama kriterlerinden ayrı kriterlerle tanımlanmaktadır. FIRS; 1) Fetal plazma IL-6 konsantrasyonun yüksek olması (IL-6>11 pg/mL),…”

Section: Fetal İnflamatuar Yanit Sendromunun Tanimlanmasiunclassified

“…30,49 Ayrıca Mikołajczyk ve ark., son çalışmalarında, servikovajinal sürüntüden baktıkları IL-6 değerinin >26,8 pg/mL üzeri saptanmasının FIRS tanımında fetal plazma değerinden daha duyarlı olduğunu raporlamışlardır. 48 FIRS'nin kesin prenatal tanısı, amniyosentez, kordosentez gibi invaziv yöntemlerle konabildiği için son yıllarda ultrasonografik metotlar aracılığıyla noninvaziv tanımlamalar üzerinde çalışılmaktadır. Bu nedenle intakt membranlı preterm doğum için ve preterm-EMR olup, preterm doğum eylemi için gelen gebelerde başta timüs olmak üzere etkilenmesi beklenen organların ultrasonografi ile taranmasının FIRS tanısında destekleyici olabileceği bildirilmektedir.…”

Section: Fetal İnflamatuar Yanit Sendromunun Tanimlanmasiunclassified

See 1 more Smart Citation

Chorioamnionitis and Its Fetal Effects

Ongun¹,

Çelik²,

Oygür³

2020

Turkiye Klinikleri J Pediatr

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Koryoamniyonit, gebelik sırasında amniyotik sıvı, umbilikal kordon ve fetal membranların enfeksiyonu ve/veya inflamasyonunu içermekte ve anne açısından endometrit, pelvik tromboflebitis, pelvik apse, postpartum kanama, fetüs açısından fetal inflamatuar yanıt sendromu [fetal inflammatory response syndrome (FIRS)], doğan bebek için erken sepsis, konjenital pnömoni, perinatal ölüm, prematüre retinopatisi, bronkopulmoner displazi [bronchopulmonary dysplasia (BPD)], intraventriküler kanama (İVK), nekrotizan enterokolit [necrotizing enterocolitis (NEC)], serebral palsi [cerebral palsy (CP)] gibi

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Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM)

Cited by 10 publications

References 28 publications

Prognostication for prelabor rupture of membranes and the time of delivery in nationwide insured women: development, validation, and deployment

Prognostication for prelabor rupture of membranes and the time of delivery in nationwide insured women: development, validation, and deployment

The Implication of Aquaporin-9 in the Pathogenesis of Preterm Premature Rupture of Membranes

Chorioamnionitis and Its Fetal Effects

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