Value of contrast‐enhanced sonography with micro flow imaging in the diagnosis of prostate cancer

Xie, Shao Wei; Li, Feng Hua; Li, Hong Li; Du, Jing; Xia, Jian Guo; Fang, Hua; Bo, Juan Jie; Zhu, Jian

doi:10.1002/jcu.20841

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…We also identified small prostate volume and small TZ volume of the prostate as significant risk factors for high-grade PCa in the simple logistic regression analysis; however, they were not significant by multiple logistic regression analysis. Another study suggested that the results of contrast-enhanced sonography with micro flow imaging are associated with the aggressiveness of PCa [18]. …”

Section: Discussionmentioning

confidence: 99%

Are Hypoechoic Lesions on Transrectal Ultrasonography a Marker for Clinically Significant Prostate Cancer?

et al. 2013

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PurposeTo investigate the relationship of transrectal ultrasound (TRUS) findings with the pathological characteristics of prostate cancer (PCa).Materials and MethodsThe study was conducted retrospectively by analyzing the data for 970 patients who underwent prostate biopsies. Gleason scores and other clinical variables were compared between PCa patients with and without hypoechoic lesions on TRUS.ResultsOf the 970 patients, PCa was diagnosed in 291 (30%). Of these, high-grade PCa (Gleason score of 7 or more) was diagnosed in 190 (65%). The cancer detection rate was higher in patients with hypoechoic lesions (43.9%) than in those without hypoechoic lesions (21.4%, p<0.001). High-grade PCa was detected more often in patients with hypoechoic lesions than in those without hypoechoic lesions (p<0.001). Independent predictors for high-grade PCa by logistic regression analysis included hypoechoic lesions on TRUS and abnormal digital rectal examination findings.ConclusionsPatients with PCa who had hypoechoic lesions on TRUS had more aggressive pathological disease than did those without lesions. Therefore, hypoechoic lesions on TRUS could be a marker for clinically significant PCa.

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Section: Discussionmentioning

confidence: 99%

Are Hypoechoic Lesions on Transrectal Ultrasonography a Marker for Clinically Significant Prostate Cancer?

et al. 2013

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“…It is most commonly used to assess blood flow, diagnose disease and measure a treatment effect. Compared with ultrasonography, contrast‐enhanced sonography does not only provide information on tissue configuration and vascularity, but can also differentiate differences in blood flow between normal and pathological tissue quantitatively (Xie et al ., ). Studies showed that contrast‐enhanced sonography can differentiate tumour vascularity in a prostate cancer animal model (Lee et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Effects of aescin on testicular repairment in rats with experimentally induced varicocele

Tian

Zhu

et al. 2013

Andrologia

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This study was conducted to investigate the effects of aescin treatment in a rodent model treated with an experimentally induced varicocele. Experimental varicocele was induced by partial ligation of the left renal vein of rats. Aescin administration was performed daily for 4 weeks after the varicocele induction. Seven weeks later, a contrast-enhanced ultrasound was performed of the rats' testis to assess testicular blood flow. The animals were sacrificed, and H&E staining was then used to evaluate testicular pathological changes and polymorphonuclear leucocytes density. Cauda epididymal sperm counts and motility were evaluated. Blood was collected for the measurement of follicle-stimulating hormone, luteinising hormone and testosterone. Contrast-enhanced ultrasound showed that there were significant decreases in testicular blood flow in the aescin-treated groups compared with those in control varicocele group. Testicular oedema was detected in those rats treated with a varicocele but without aescin, while no oedema was found in the experimental group. H&E staining showed dysfunctional spermatogenesis in both cohorts; however, polymorphonuclear leucocytes density was significantly reduced in aescin-treated groups. There was an increase in sperm counts of the aescin-treated groups. Our study demonstrated that aescin could exert therapeutical effects on reversal of testicular lesions in varicocele rats.

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“…At present, few studies have reported the possibility of detecting PCa using three‐section CETRUS. In a previously published study, Xie and colleagues reported their findings using three‐section CETRUS with micro flow imaging technique. They found that by site the sensitivity, specificity, accuracy, PPV, and NPV for micro flow imaging were 81.1%, 84.3%, 83.3%, 68.6%, and 91.3%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In case of disagreement, another senior sonologist would review all the images until a consensus was achieved. Sonologists used the following criteria on the basis of our clinical experience and previous literature: TRUS: (1) focal hypoechoic foci in the peripheral zone (PZ); (2) asymmetric bulging of contours; (3) ill‐defined separation between PZ and transition zone (TZ); (4) focal asymmetric/increased flow on PDUS. CETRUS: (1) stronger or faster contrast enhancement compared with adjacent parenchyma; (2) no or low enhancement; (3) indistinct separation between the inner and outer glands; (4) asymmetry of intraprostatic vessels. Additionally, to measure the maximum diameter of suspicious lesions on each imaging, methods used successfully in our previous study were applied .…”

Section: Methodsmentioning

confidence: 99%

Value of three-section contrast-enhanced transrectal ultrasonography in the detection of prostate cancer

Sun

et al. 2017

J. Clin. Ultrasound

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Value of contrast‐enhanced sonography with micro flow imaging in the diagnosis of prostate cancer

Abstract: Some MFI patterns had high positive predictive values and were associated with more aggressive cancers. This could be used to reduce the number of biopsy sites and detect clinically significant cancers.

Cited by 10 publications

References 21 publications

Are Hypoechoic Lesions on Transrectal Ultrasonography a Marker for Clinically Significant Prostate Cancer?

Are Hypoechoic Lesions on Transrectal Ultrasonography a Marker for Clinically Significant Prostate Cancer?

Effects of aescin on testicular repairment in rats with experimentally induced varicocele

Value of three-section contrast-enhanced transrectal ultrasonography in the detection of prostate cancer

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