Value of Contrast-Enhanced Ultrasonography in the Differential Diagnosis of Enlarged Lymph Nodes: a Meta-Analysis of Diagnostic Accuracy Studies

Jin, Ying; He, Yaqian; Zhang, Mingming; Parajuly, Shyam Sundar; Chen, Shuang; Zhao, Hanqing; Peng, Yulan

doi:10.7314/apjcp.2015.16.6.2361

Cited by 18 publications

(11 citation statements)

References 27 publications

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“…Dudau et al observed 17 cervical metastatic lymph nodes from squamous carcinoma and discovered that perfusion defects or nonuniform enhancements were present in 13 metastatic lymph nodes. A meta‐analysis found that contrast‐enhanced US could differentiate between benign and malignant lymph nodes with relatively high sensitivity and specificity, a relatively high positive likelihood ratio and diagnostic odds ratio, and a relatively low negative likelihood ratio. Therefore, contrast‐enhanced US has high clinical value for the diagnosis of malignant lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…Two-dimensional and color Doppler US examinations are the first-line diagnostic methods for supraclavicular lymph node metastasis from lung cancer, but the diagnostic specificity is limited. 11,12 Fine-needle aspiration biopsy and cytologic examination is the reference standard for a definite diagnosis of lymph node metastasis, but it is also subject to sampling error and limited by the experience of the physician who takes the samples as well as the pathologist who makes the diagnosis. 13 The second-generation US microbubble contrast agent SonoVue can facilitate the observation of blood perfusion signals within tissues in real time and can help in understanding information related to blood distribution.…”

Section: Discussionmentioning

confidence: 99%

“…Two‐dimensional and color Doppler US examinations are the first‐line diagnostic methods for supraclavicular lymph node metastasis from lung cancer, but the diagnostic specificity is limited . Fine‐needle aspiration biopsy and cytologic examination is the reference standard for a definite diagnosis of lymph node metastasis, but it is also subject to sampling error and limited by the experience of the physician who takes the samples as well as the pathologist who makes the diagnosis…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of Contrast‐Enhanced Ultrasound Perfusion Patterns and Time‐Intensity Curves for Metastatic Lymph Nodes From Lung Cancer: Preliminary Results

Yin

Cui

Wang

et al. 2017

J of Ultrasound Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Analysis of Contrast‐Enhanced Ultrasound Perfusion Patterns and Time‐Intensity Curves for Metastatic Lymph Nodes From Lung Cancer: Preliminary Results

Yin

Cui

Wang

et al. 2017

J of Ultrasound Medicine

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“…[ 60 61 ] In the performed studies, this effect has been described and can even been seen in a meta-analysis study. [ 62 ] However, the same pathophysiological problems mentioned above have to be taken into account. Lymphoma LNs are known to have a good vascularization in the capillary bed and cannot be identified using the method.…”

Section: Contrast Harmonic Imaging In Endoscopic Ultrasoundmentioning

confidence: 99%

Role of contrast-enhanced endoscopic ultrasound in lymph nodes

2017

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Diagnosing unclear lymph node (LN) enlargements in the mediastinum and abdomen is the most important indication of endoscopic ultrasound (EUS)-fine needle aspiration (FNA) after the diagnosis and treatment of pancreatic diseases. Investigating LNs in these areas can happen in different clinical settings. Mostly, it is the first modality in general LN diseases without any peripheral LN enlargements. On the other hand, it can be the question of LN involvement in a known or suspected primary tumor. Due to EUS-FNA cytology, those questions can be answered highly, accurately. However, a primary discrimination of LNs might be helpful to increase the diagnostic value of the FNA cytology, especially in cases with multiple LN enlargements and hard to reach enlarged LNs for example by vessel interposition. Because of the unreliability of B-mode criteria, further diagnostic improvements such as elastography and contrast-enhanced EUS are investigated to increase the accuracy of the initial diagnosis.

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“…Several meta-analyses [10–14] of differentiating between benign and malignant LNs have been published in recent years, however, as far as we know, there still lacks a systematic evaluation of ARFI with VTQ and VTIQ for the differential diagnosis of LNs. As a consequence, we conducted this systematic review and meta-analysis to investigate the performance of ARFI using VTQ or VTIQ in the diagnosis of LNs.…”

Section: Introductionmentioning

confidence: 99%

Acoustic Radiation Force Impulse Imaging for the Differentiation of Benign and Malignant Lymph Nodes: A Systematic Review and Meta-Analysis

Zhang

Zheng

et al. 2016

PLoS ONE

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ObjectiveTo evaluate the overall performance of acoustic radiation force impulse imaging (ARFI) in differentiating between benign and malignant lymph nodes (LNs) by conducting a meta-analysis.MethodsPubMed, Embase, Web of Science, the Cochrane Library and the China National Knowledge Infrastructure were comprehensively searched for potential studies through August 13th, 2016. Studies that investigated the diagnostic power of ARFI for the differential diagnosis of benign and malignant LNs by using virtual touch tissue quantification (VTQ) or virtual touch tissue imaging quantification (VTIQ) were collected. The included articles were published in English or Chinese. Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used to evaluate the methodological quality. The pooled sensitivity, specificity, and the area under the summary receiver operating characteristic (SROC) curve (AUC) were calculated by means of a bivariate mixed-effects regression model. Meta-regression analysis was performed to identify the potential sources of between study heterogeneity. Fagan plot analysis was used to explore the clinical utilities. Publication bias was assessed using Deek’s funnel plot.ResultsNine studies involving 1084 LNs from 929 patients were identified to analyze in the meta-analysis. The summary sensitivity and specificity of ARFI in detecting malignant LNs were 0.87 (95% confidence interval [CI], 0.83–0.91) and 0.88 (95% CI, 0.82–0.92), respectively. The AUC was 0.93 (95% CI, 0.90–0.95). The pooled DOR was 49.59 (95% CI, 26.11–94.15). Deek’s funnel plot revealed no significant publication bias.ConclusionARFI is a promising tool for the differentiation of benign and malignant LNs with high sensitivity and specificity.

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Value of Contrast-Enhanced Ultrasonography in the Differential Diagnosis of Enlarged Lymph Nodes: a Meta-Analysis of Diagnostic Accuracy Studies

Cited by 18 publications

References 27 publications

Analysis of Contrast‐Enhanced Ultrasound Perfusion Patterns and Time‐Intensity Curves for Metastatic Lymph Nodes From Lung Cancer: Preliminary Results

Analysis of Contrast‐Enhanced Ultrasound Perfusion Patterns and Time‐Intensity Curves for Metastatic Lymph Nodes From Lung Cancer: Preliminary Results

Role of contrast-enhanced endoscopic ultrasound in lymph nodes

Acoustic Radiation Force Impulse Imaging for the Differentiation of Benign and Malignant Lymph Nodes: A Systematic Review and Meta-Analysis

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