Value of Diagnostic Radioiodine Whole-Body Scanning After Initial Therapy in Patients with Differentiated Thyroid Cancer at Intermediate and High Risk for Recurrence

Rosário, Pedro Weslley; Furtado, Mariana de Souza; Filho, Augusto Flávio Campos Mineiro; Lacerda, Rafaela Xavier; Calsolari, Maria Regina

doi:10.1089/thy.2012.0026

Cited by 22 publications

(3 citation statements)

References 19 publications

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“…A mutation of TERT promoter was found in about 7.5% of PTCs, which induced the abnormal activation of telomerase is closely related to the invasive clinical behavior of papillary carcinoma (69). Moreover, it was revealed that TERT promoter mutation is a major indicator of extremely poor prognosis and aggressive clinicopathological characteristics (13). It also demonstrated that coexistence of BRAF V600E and TERT promoter mutations are the most aggressive subgroup in PTCs patients, while PTCs with BRAF or TERT alone are less aggressive (70).…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, the main treatment of primary/recurrent/ advanced PTC is still reliant on surgical resection of total thyroidectomy (TT) (12). The radioiodine ablation (RAI) and lifelong levothyroxine therapy are commonly performed in intermediate-and high-risk patients (13). Although, PTC exhibit indolent behavior and bring a relatively low disease-specific mortality, with early-dissemination to local lymph nodes and oppression to organs, recurrence is comparatively common locally and distantly (14).…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

et al. 2020

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Purpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients. Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020. Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age <45 years (pooled OR = 1.52, 95% CI = 1.14-2.01, p < 0.00001); gender = male (pooled OR = 1.68, 95% CI = 1.51-1.87, p < 0.00001); multifocality (pooled OR = 2.05, 95% CI = 1.45-2.89, p < 0.0001); tumor size ≥1.0 cm (pooled OR = 3.53, 95% CI = 2.62-4.76, p < 0.00001); tumor location at the upper pole 1/3 (pooled OR =1.46, 95% CI = 1.04-2.04, p = 0.03); capsular invasion + (pooled OR = 3.48, 95% CI = 1.69-7.54, p = 0.002); and extrathyroidal extension + (pooled OR = 2.03, 95% CI= 1.78-2.31, p < 0.00001). However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54-1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79-1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients. Conclusion: The systematic review and meta-analysis defined several significant risk factors of lymph node metastasis in papillary thyroid cancer patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion, and extra thyroidal extension. Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

et al. 2020

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“…Treatment modalities are dependent on site, size, nature, stage or grade of tumor 11 . Total thyroid resection is most reliable therapeutic option for MNG 12 .…”

Section: Introductionmentioning

confidence: 99%

Incidental Findings of Papillary Carcinoma in Thyroid Observing patients of Previously Operated Clinical Specimens of Multinodular Goiter

Zafar,

Samad,

Haroon

et al. 2023

PJMHS

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Background: Papillary carcinoma is one of the common malignancy among all thyroid malignancies and constitutes about 57-75%. In most of cases this lesion is an incidental finding in biopsies specimens operated for MNG. But the incidence of papillary carcinoma in the setting of various thyroid disorders including MNG remains unclear. Hence, we conducted a study of five years from 2017 till 2021 to address this question. Aim: To rule out the incidence of Papillary Thyroid Carcinoma (PTC) especially associated connection with MNG Methodology: From retrospective study carried out in the pathology department of Ibne-Sina Hospital, Multan, the date of 631 cases of thyroid carcinomas were retrieved. All the patients underwent different thyroid surgeries. Data regarding the age, gender, clinical diagnosis as well as pathological diagnosis was recorded and results were analyzed on SPSS 25. Results: We reviewed 631 cases of thyroid and included in the analysis. Overall, n=558 cases were operated with clinical diagnosis of MNG. Among them, 54(10%) cases were reported as papillary carcinoma on the basis of histopathological examination. Conclusions: Incidentally discovered papillary thyroid carcinomas are more commonly identified in surgical specimens from cases with MNG. These findings highlighted the high risk of malignancy in MNG emphasizing on the fact that the carcinoma should never be underestimated as majority of these patients were presented with clinically diagnosis of MNG. Keywords: MNG, papillary thyroid carcinoma, malignancy

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Trends in imaging after diagnosis of thyroid cancer

Wiebel

Banerjee

Muenz

et al. 2015

Cancer

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Background The largest growth in differentiated thyroid cancer (DTC) diagnosis is in low-risk cancers. Trends in imaging after DTC diagnosis are understudied. Hypothesizing a reduction in imaging utilization due to rising low-risk disease, we evaluated post-diagnosis imaging patterns over time and patient characteristics that are associated with likelihood of imaging. Methods Using the Surveillance Epidemiology and End Results-Medicare database, we identified patients diagnosed with localized, regional or distant DTC between 1991 and 2009. We reviewed Medicare claims for neck ultrasound, I-131 scan, or PET scan within 3 years post-diagnosis. Using regression analyses we evaluated trends of imaging utilization. Multivariable logistic regression was used to estimate the likelihood of imaging based on patient characteristics. Results 23,669 patients were included. Patients diagnosed during 2001-2009, compared to 1991-2000, were more likely to have localized disease (p<0.001) and tumors less than 1cm (p<0.001). Use of neck ultrasound and I-131 scan increased in patients with localized disease (p=<0.001 and p=0.003, respectively), regional disease (p<0.001 and p<0.001), and distant metastasis (p=0.001 and p=0.015). Patients diagnosed after 2000 were more likely to undergo neck ultrasound (OR 2.15, 95% CI 2.02-2.28) and I-131 scan (OR 1.44, 95% CI 1.35-1.54). PET scan use from 2005-2009, compared to 1996-2004, increased 32.4-fold (p=<0.001) in localized patients, 13.1-fold (p<0.001) in regional disease patients, and 33.4-fold (p<0.001) in patients with distant DTC. Conclusion Despite a rise in low-risk disease, the use of post-diagnosis imaging increased in all stages of disease. The largest growth was in use of PET scan after 2004.

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Value of Diagnostic Radioiodine Whole-Body Scanning After Initial Therapy in Patients with Differentiated Thyroid Cancer at Intermediate and High Risk for Recurrence

Abstract: DxWBS can be avoided in patients with large tumors or extensions beyond the thyroid capsule or lymph node metastases, but who show no apparent disease upon initial RxWBS and US and whose serum TgT4 of <1 ng/mL and negative TgAb after thyroidectomy and ablation.

Cited by 22 publications

References 19 publications

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

Incidental Findings of Papillary Carcinoma in Thyroid Observing patients of Previously Operated Clinical Specimens of Multinodular Goiter

Trends in imaging after diagnosis of thyroid cancer

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