1966
DOI: 10.1111/j.1365-2141.1966.tb05638.x
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Value of Erythrocyte Protoporphyrin in the Diagnosis of Latent Iron Deficiency (Sideropenia)

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Cited by 78 publications
(25 citation statements)
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“…The secondary accumulation of its substrate, AmLev, can affect the neurological system in a manner similar to the action ofporphobilinogen (31,32). The clinical symptomatology of Pb poisoning is close to that of acute intermittent porphyria, a disorder with accumulation of both AmLev and porphobilinogen (33). The accumulation of AmLev is reflected by its increased excretion in the urine, which is exponentially correlated with BPb (24).…”
mentioning
confidence: 95%
“…The secondary accumulation of its substrate, AmLev, can affect the neurological system in a manner similar to the action ofporphobilinogen (31,32). The clinical symptomatology of Pb poisoning is close to that of acute intermittent porphyria, a disorder with accumulation of both AmLev and porphobilinogen (33). The accumulation of AmLev is reflected by its increased excretion in the urine, which is exponentially correlated with BPb (24).…”
mentioning
confidence: 95%
“…A hepatic porphyria resulting from the inherited deficiency of ALA-D activity has been described (18). This porphyria is of particular interest since it implicates ALA accumulation as a cause of the neurologic manifestations in acute intermittent porphyria and lead poisoning (19,20), The role of ALA as a neurotoxic agent has been supported by the finding that it is a potent agonist of y-aminobutyric acid presynaptic receptors (21,22).…”
mentioning
confidence: 99%
“…Significant "leakage" of protoporphyrin from intact circulating erythrocytes into the plasma has been ruled out by direct experimental observation (5). Furthermore, no increase in fecal porphyrin excretion is demonstrable in lead intoxication and in iron deficiency (6), both of which are associated with high levels of free red cell protoporphyrin (6)(7)(8). Second, investigation of kinships with the disease revealed several affected individuals with elevated fecal porphyrin excretion who failed to exhibit a concomitant increase in red cell protoporphyrin (9,10).…”
Section: Introductionmentioning
confidence: 99%