Value of fine‐needle aspiration biopsy of salivary gland lesions

Christensen, Rikke Kølby; Bjørndal, Kristine; Godballe, Christian; Krogdahl, Annelise

doi:10.1002/hed.21151

Cited by 63 publications

(66 citation statements)

References 16 publications

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“…The calculation of positive predictive value and negative predictive value has not been conducted elsewhere for oral lesions, but, for glandular lesions, the values were found to vary from 83% to 100% and 87.8% to 99%, respectively. 1,5,13,15 The rates of false positives and false negatives in this study were 6.7% and 13.3%, respectively. These figures agree with those reported in the literature, which indicates that the false positive rate typically varies from 0 to 3% and that the false negative rate varies from 0 to 20%.…”

Section: Discussionmentioning

confidence: 49%

Fine needle aspiration biopsy in the oral cavity and head and neck region

et al. 2011

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Abstract:The objective of the current study was to evaluate the sensitivity, specificity and accuracy of fine needle aspiration biopsy (FNAB) of submucous nodules from the oral cavity and head and neck region as an auxiliary diagnostic tool. Fifty patients with nodule lesions in the oral cavity and the head and neck region were selected. All of them were submitted to FNAB and to either incisional or excisional biopsy. The diagnoses from the FNABs were compared with the biopsy diagnosis as the gold standard. All the cases of FNAB were analyzed by a single oral pathologist prior to the biopsy diagnosis. The results showed that the sensitivity of FNAB was 75%, its specificity was 96% and its accuracy was 58.8%. The false positive and false negative rates were 6.7% and 13.3%, respectively. The positive predictive value was 86% and the negative predictive value was 93%. The inconclusive rate was 16/50. FNAB displayed a high success rate for identifying both malignant and benign lesions, but a low accuracy for making a final diagnosis.

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Section: Discussionmentioning

confidence: 49%

Fine needle aspiration biopsy in the oral cavity and head and neck region

et al. 2011

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“…Third, subjects lacking an adequate understanding of genetic testing and its potential implications are a susceptible target for inappropriate genetic testing such as that offered directly to the consumer over the Internet in the absence of solid evidence about clinical utility [38]. Genome-based health literacy is also of relevance to policy setting [38]. Finally genome-based misconceptions can have problematic implications for how people stereotype and think about subgroups of the population [38].…”

Section: Focusing On the Usermentioning

confidence: 99%

“…pharmacogenomic testing such as in the case of a specific cancer diagnosis). Third, subjects lacking an adequate understanding of genetic testing and its potential implications are a susceptible target for inappropriate genetic testing such as that offered directly to the consumer over the Internet in the absence of solid evidence about clinical utility [38]. Genome-based health literacy is also of relevance to policy setting [38].…”

Section: Focusing On the Usermentioning

confidence: 99%

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Genome-Based Health Literacy: A New Challenge for Public Health Genomics

Syurina

Branković

Probst‐Hensch

et al. 2011

Public Health Genomics

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So far health literacy has not been sufficiently discussed in the context of public health genomics. Primarily, not genomic but rather genome-based health information needs to be addressed taking into account genome-environment interactions and integrating all health determinants including genomics into a systemic and holistic approach. Translating findings from epigenomics and systems biomedicine will help to understand that individual biological pathways or networks are permanently interacting with environmental networks such as social networks. Thus, in the end also health literacy will become personalized. Genome-based health literacy is challenged by the question of which information is relevant for the individual, for what purpose, and at what time during the lifespan. Public health tools and expertise already in place can and should be used to tackle these huge challenges.

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“…3). FNA has an excellent specificity and good sensitivity in separating benign from malignant lesions in both the major and oral minor salivary glands (65). However, ACC shows occasional cytological overlap with pleomorphic adenoma, basal cell adenocarcinoma, and polymorphous adenocarcinoma (66).…”

Section: Clinical Characteristicsmentioning

confidence: 99%