Value of fractional exhaled nitric oxide (FENO) for the diagnosis of pulmonary involvement due to inflammatory bowel disease

Özyılmaz, Ezgi; Yıldırım, Beytullah; Erbaş, Gonca; Akten, Serpil; Oğuzülgen, I. Kıvılcım; Tunç, Bilge; Tuncer, Candan; Türktaş, Haluk

doi:10.1002/ibd.21085

Cited by 32 publications

(38 citation statements)

References 37 publications

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“…The Authors found high levels of FeNO in CD patients, and established a negative correlation between CDA and pulmonary function indexes (forced expiratory volume in one second and forced vital capacity), and went on to suggest the presence of a link between bronchial inflammation and systemic disease activity in CD. Another recent study by Ozyilmaz et al confirmed the correlation between FeNO levels and disease activity in patients with CD and ulcerative colitis (UC) (23). While these studies only considered FeNO levels (measured at 50 mils), and only contemplated one single exam per patient, the current study analyses eNO with multiple flow rates and at different stages of each patient's clinical and treatment courses.…”

Section: Discussionmentioning

confidence: 83%

Exhaled Nitric Oxide as a Marker of Lung Involvement in Crohn's Disease

Malerba

Ragnoli

Buffoli

et al. 2011

Int J Immunopathol Pharmacol

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Crohn's Disease is an inflammatory bowel disease associated with a variety of systemic manifestations, including large and small airway involvement. The latter is most often a subclinical one, and requires expensive and invasive diagnostic approaches. Nitric Oxide (NO) can be detected non-invasively in the exhaled air (eNO) and be considered as a surrogate marker of airway inflammation. eNO tested at multiple expiratory flows can be used to distinguish the alveolar concentration of NO (CalvNO) from the total amount of fractional eNO (FeNO). The aim of our study is to compare FeNO and concentration of alveolar nitric oxide (CalvNO) levels and to assess their relationship with pulmonary involvement in Crohn's patients differing in clinical stage and therapeutic regimens versus a group of healthy subjects. Thirty Crohn's patients not showing clinical evidence of pulmonary diseases and 21 non-smoking, non-atopic healthy controls were enrolled. FeNO (14.9±10.2 ppb vs 10.1±6.3 ppb, p=0.049) and CaIvNO (4.4±2.2 ppb vs 2.6±1.9; p=0.006) values were found to be significantly higher in Crohn's patients than in healthy controls. Both FeNO and CaIvNO correlated positively with the Crohn's Disease Activity Index. In conclusion, our results for FeNO and CaIvNO confirm the presence of subclinical pulmonary involvement in Crohn's disease. eNO measurement may be of clinical value in the follow-up of Crohn's patients.

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Section: Discussionmentioning

confidence: 83%

Exhaled Nitric Oxide as a Marker of Lung Involvement in Crohn's Disease

Malerba

Ragnoli

Buffoli

et al. 2011

Int J Immunopathol Pharmacol

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“…This parameter is considered to be a marker of airway inflammation. At least three independent authors found increased eNO in IBD patients compared to control subjects [37][38][39].…”

Section: Epidemiologymentioning

confidence: 99%

“…Bronchial hyperresponsiveness on methacholine challenge was independent of activity, extent and time of duration of IBD [29][30][31]. Exhaled NO correlated positively with IBD activity [37][38][39], but no relation was found for alveolar epithelial per-meability measured with the use of Tc-99m DTPA aerosol scintigraphy [40,41]. Data on relationship between IBD activity and chest HRCT picture are discrepant.…”

Section: Respiratory Disease Depending On Ibd Activitymentioning

confidence: 99%

Respiratory System Involvement in Inflammatory Bowel Diseases

Kacprzak¹,

Szturmowicz²,

Kuś³

2017

Advances in Respiratory Medicine

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“…The lung pathology, related to the use of these medicines includes interstitial disease [20][21][22][23], eosinophilic pleuritis [24], eosinophilic pneumonia [25][26][27], and bronchiolitis obliterans [28]. Biological therapy, with anti-TNF drugs such as infliximab, adalimumab and certolizumab, has been associated with several opportunistic infections, as a result of suppression of Tcell-mediated immunity, the most frequent being tuberculosis [29,30].…”

Section: Drug Side-effects To the Lungsmentioning

confidence: 99%

Crosstalk between the Lungs and the Gut in Inflammatory Bowel Diseases

Triantafyllakis¹,

Giagkou²,

Malakos³

et al. 2017

Chron Obstruct Pulmon Dis

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Pulmonary involvement seems to be a more frequent extraintestinal manifestation of IBD than thus far supposed. In IBD, the respiratory involvement may include a wide range of pathologies. The patients with IBD are in high risk of infections. The drugs used in the treatment of IBD (sulfasalazine, mesalamine, infliximab, and methotrexate) can induce pulmonary diseases as a side effect.Pulmonary function tests and high resolution CT are useful for detecting subclinical or clinical pulmonary involvement in IBD patients. Pulmonary function tests (PFT) and high-resolution CT (HRCT) showed abnormality in about one-quarter of patients with IBD. Corticosteroids, both systemic and aerosolized, are the main therapeutical approach, while antibiotics must also be administered in infections. Early identification is important as early treatment may improve long-term outcomes in these patients.

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Value of fractional exhaled nitric oxide (FENO) for the diagnosis of pulmonary involvement due to inflammatory bowel disease

Abstract: This study showed that an increased FE(NO) level may be used for identifying patients with IBD who need further pulmonary evaluation.

Cited by 32 publications

References 37 publications

Exhaled Nitric Oxide as a Marker of Lung Involvement in Crohn's Disease

Exhaled Nitric Oxide as a Marker of Lung Involvement in Crohn's Disease

Respiratory System Involvement in Inflammatory Bowel Diseases

Crosstalk between the Lungs and the Gut in Inflammatory Bowel Diseases

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