2022
DOI: 10.29228/jamp.52293
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Value of Gingival Crevicular Fluid Levels of Biomarkers IL-1 β, IL-22 and IL-34 for the Prediction of Severity of Periodontal Diseases and Outcome of Non-Surgical Periodontal Treatment

Abstract: Interleukins (IL) -1β, -22 and -34 play a crucial role in osteoclastogenesis and bone resorption through modulating inflammatory processes and osteoclastogenesis. To date, there is no study investigating both gingival crevicular fluid (GCF) ILs -22 and -34 levels before and after non-surgical periodontal treatment in patients with aggressive periodontitis (AgP) and chronic periodontitis (CP). We aimed to examine the relationship of GCF levels of biomarkers IL-1 β, IL-22 and IL-34 with the clinical evidence of … Show more

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“…In our previous study, we evaluated GCF IL-34 in chronic and aggressive periodontitis. We were informed that GCF IL-34 level was increased in the aggressive periodontitis group after initial periodontal therapy while this was the opposite in the chronic periodontitis group (31). When we look at the results of the current study, GCF IL-34 levels were significantly higher in the periodontitis groups compared with the periodontal healthy groups at the beginning.…”
Section: Discussionmentioning
confidence: 74%
“…In our previous study, we evaluated GCF IL-34 in chronic and aggressive periodontitis. We were informed that GCF IL-34 level was increased in the aggressive periodontitis group after initial periodontal therapy while this was the opposite in the chronic periodontitis group (31). When we look at the results of the current study, GCF IL-34 levels were significantly higher in the periodontitis groups compared with the periodontal healthy groups at the beginning.…”
Section: Discussionmentioning
confidence: 74%