Value of hematological indices versus VEGF as biomarkers of activity in Behçet’s disease

Gheita, Tamer A.; Sakr, Basma R.; Rabea, R E; Elhamid, Samah Abd

doi:10.1007/s10067-019-04513-5

Cited by 23 publications

(16 citation statements)

References 59 publications

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“…Several recent studies have noted a significant increase in RDW in patients with a history of BD regardless of disease activity [19,29,30]. Uzkeser et al found increased MPV in patients with BD compared to a healthy control group, along with a significant positive correlation between MPV and BD manifestations such as oral and genital ulcers, ocular involvement, and arthritis [31].…”

Section: Discussionmentioning

confidence: 99%

Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)

Masoumi¹,

Shadmanfar²,

Davatchi³

et al. 2020

Orphanet J Rare Dis

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Background A strong correlation was previously found between mean platelet volume (MPV), red blood cell distribution width (RDW), and the severity of signs and symptoms in patients suffering from inflammatory and autoimmune diseases. The current study evaluated these correlations in patients with Behçet’s disease (BD) as well the relationship between MPV and RDW and disease activity score on the Iranian Behçet’s Disease Dynamic Activity Measurement (IBDDAM). Methods This cross-sectional study included 319 patients with BD for whom demographic and epidemiological data, IBDDAM scores, and duration of illness was recorded. Blood samples were then obtained and the relationships between their disease status and manifestations and their laboratory parameters were evaluated with statistical models to find possible correlations. Results Our analysis showed a significantly higher RDW in patients with BD who had ocular manifestations (p < 0.001) and oral aphthae (p = 0.004). Patients with active BD had higher RDW (p < 0.001) and MPV (p < 0.001) in comparison to those with currently inactive BD. Similarly, patients who had any type of ocular manifestation had higher RDW (p < 0.001) and MPV (p < 0.001). Regression analyses identified a statistically significant model for the effect of RDW and MPV in predicting active BD status (p < 0.001), as well as its significant relationship with active ocular manifestations (p < 0.001). Conclusion BD was found to be associated with an increase in MPV and RDW, particularly during active phases. RDW and MPV were also found to have predictive value for screening to detect BD activity and its ocular complications.

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Section: Discussionmentioning

confidence: 99%

Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)

Masoumi¹,

Shadmanfar²,

Davatchi³

et al. 2020

Orphanet J Rare Dis

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“…Among 241 eligible studies meeting the inclusion criteria, 76 articles were excluded due to unextractable data, insufficient data on HCs, irrelevant VEGF sample type (urine/synovial fluid/tear fluid), or inappropriate disease control groups. Finally, 165 studies were included in the meta-analysis, with 28,29,40,13,8,12,16,23, and six studies on SLE (20,21,, RA (12, 22-24, 38, 43, 52-74), SSc (11,38,39,64,, BD (111)(112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123), KD (18,(124)(125)(126)(127)(128)(129)(130), AS (55,73,(131)(132)(133)(134)(135)(136)(137)(138)(139)(140)…”

Section: Search Results and Population Characteristicsmentioning

confidence: 99%

Association of Circulating Vascular Endothelial Growth Factor Levels With Autoimmune Diseases: A Systematic Review and Meta-Analysis

Zhan

Liu

et al. 2021

Front. Immunol.

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BackgroundAutoimmune diseases (ADs) are characterized by immune-mediated tissue damage, in which angiogenesis is a prominent pathogenic mechanism. Vascular endothelial growth factor (VEGF), an angiogenesis modulator, is significantly elevated in several ADs including rheumatoid arthritis (RA), systemic sclerosis (SSc), and systemic lupus erythematosus (SLE). We determined whether circulating VEGF levels were associated with ADs based on pooled evidence.MethodsThe analyses included 165 studies from the PubMed, EMBASE, Cochrane Library, and Web of Science databases and fulfilled the study criteria. Comparisons of circulating VEGF levels between patients with ADs and healthy controls were performed by determining pooled standard mean differences (SMDs) with 95% confidence intervals (CIs) in a random-effect model using STATA 16.0. Subgroup, sensitivity, and meta-regression analyses were performed to determine heterogeneity and to test robustness.ResultsCompared with healthy subjects, circulating VEGF levels were significantly higher in patients with SLE (SMD 0.84, 95% CI 0.25–1.44, P = 0.0056), RA (SMD 1.48, 95% CI 0.82–2.15, P <0.0001), SSc (SMD 0.56, 95% CI 0.36–0.75, P <0.0001), Behcet’s disease (SMD 1.65, 95% CI 0.88–2.41, P <0.0001), Kawasaki disease (SMD 2.41, 95% CI 0.10–4.72, P = 0.0406), ankylosing spondylitis (SMD 0.78, 95% CI 0.23–1.33, P = 0.0052), inflammatory bowel disease (SMD 0.57, 95% CI 0.43–0.71, P <0.0001), psoriasis (SMD 0.98, 95% CI 0.62–1.34, P <0.0001), and Graves’ disease (SMD 0.69, 95% CI 0.20–1.19, P = 0.0056). Circulating VEGF levels correlated with disease activity and hematological parameters in ADs.ConclusionCirculating VEGF levels were associated with ADs and could predict disease manifestations, severity and activity in patients with ADs.Systematic Review RegistrationPROSPERO, identifier CRD42021227843.

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“…The age and gender distributions of the groups were as similar (P = .839 and P = .095, respectively). The patients were at least 1 year and at most 30 years disease duration with a median of 5 (3)(4)(5)(6)(7)(8)(9). Of 217 patients, 127 (58.5%) had genital ulcer, 128 (59%) skin lesions, 73 (33.6%) arthritis, 83 (38.2%) uveitis, 51 (23.5%) thrombosis, 21 (9.7%) had neuro-Behcet's disease (NBD), 4 (1.8%) entero-Behcet's disease (entero-BD), 111 (51.2%) pathergy test positivity and 99 (45.6%) had HLA-B51 positivity.…”

Section: Re Sultsmentioning

confidence: 99%

“…6 Recent studies show that high MLR, NLR, PLR MPV, RDW and PCT levels may reflect inflammation and oxidative stress in chronic inflammatory and autoimmune diseases. 7 These parameters are considered cost-effective and simple laboratory parameters that may indicate systemic inflammation in many diseases.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of diagnostic performance of haematological parameters in Behçet’s disease

et al. 2021

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Objective: Behçet's Disease (BD) is a polygenic and chronic autoinflammatory multisystemic vasculitis disease characterised by mucocutaneous, musculoskeletal, neurological, gastrointestinal and ophthalmologic lesions. There has been no specific test or serum marker to measure and determine the diagnosis and severity of BD. Purpose:The study aimed to investigate the diagnostic performance of haematological parameters as MLR (monocyte to lymphocyte ratio), NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), MPV (mean platelet volume), MPVPR (mean platelet volume to platelet ratio), LMR (lymphocyte to monocyte ratio), LPM (lymphocyte and platelet multiplication), WLP (lymphocyte and leukocyte multiplication), RDW (red blood cell distribution width) and PCT (plateletcrit) in BD and compare these with disease activity and clinical findings.Methods: A total of 266 participants (49 healthy control and 217 BD patients) were recruited from the rheumatology department in a single-centre as a case-control study. The laboratory data were obtained from the electronic registration database.BD Activity scores (BDCAF/Behcet's Disease Current Activity Form) were calculated. Laboratory findings of BD patients and healthy controls were compared and evaluated.Results: RDW, Platelet, PCT, NLR and PLR values were significantly higher in patient group than in the healthy controls. However, haemoglobin, MPVPR and LMR were significantly lower in the patient group which compared with the healthy controls.LPM in BD with genital ulcers, WLP in BD with genital ulcers and arthritis, MPR in BD with uveitis, RDW in BD with thrombosis and neuro-Behçet's disease (NBD), PLR in NBD were observed to be higher. However, LMR in NBD and MPV in BD with thrombosis were lower than those without. There was a positive correlation between BDCAF score and RDW, and NLR.

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Value of hematological indices versus VEGF as biomarkers of activity in Behçet’s disease

Cited by 23 publications

References 59 publications

Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)

Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)

Association of Circulating Vascular Endothelial Growth Factor Levels With Autoimmune Diseases: A Systematic Review and Meta-Analysis

Evaluation of diagnostic performance of haematological parameters in Behçet’s disease

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