Value of Hydroxyproline Indices in Malnutrition

The progress of fracture union requires close monitoring. Whereas, clinical examination and radiographic studies assess the outcome, biochemical markers like serum alkaline phosphatase and urinary hydroxyproline reflect the actual status of bone resorption and bone formation over a short time frame. 36 patients of long bone fracture were randomly allocated for the study. When the patient reported to the Department of Orthopedics after fracture, serum and urinary samples were collected and X-ray of the affected part were taken. Subsequent samples were collected and X-ray taken just after management (either operative or conservative), after 3rd, 5th, 8th and 12th week, respectively after onset of fracture. According to the course of callus formation the patients were divided into two groups that progressed to proper union or malunion. The levels of serum alkaline phosphatase, urinary total and free hydroxyproline levels were measured and statistically analysed and compared. A statistically significant positive correlation between total urinary hydroxyproline excretion and serum alkaline phosphatase indicate progress towards satisfactory union. Thus, serial monitoring of biochemical markers of bone turnover can be used as an adjunct to clinical and radiological evidence of fracture healing.

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“…Subsequently, it has been shown that the ratio determined in random samples of urine is similar to that found in a 24 h collection [20].…”

Section: Discussionmentioning

confidence: 52%

Role of Common Biochemical Markers for the Assessment of Fracture Union

Mukhopadhyay¹,

Sinha²,

Pal

et al. 2011

Ind J Clin Biochem

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“…The validity of results obtained in random samples of urine is based on previous reports where THP:Cr of 24 h specimens was compared with the results obtained in spot samples from the same period. Howells, Wharton & McCance(1967) observed that the ratios were closely correlated (r = 0.98; P<O.OOl). Younoszai, Kacic, Dilling & Haworth (1969) found a good correlation for low values, but at higher ratios the spread was greater.…”

mentioning

confidence: 79%

“…Meanwhile, it is advisable to collect spot Correspondence urine samples at the same hour of the day, as was done by Wharton et al (1973). The hour of collection should be recorded to permit adequate inter-laboratory comparison, a precaution not taken in the majority of the published studies (Whitehead, 1965;Howells et al, 1967;Crowne, Wharton & McCance, 1969;Younoszai et al, 1969).…”

mentioning

confidence: 99%

Circadian Rhythm of the Total Hydroxyproline: Creatinine Ratio in Urine

Mautalén¹

1974

Clinical Science

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Circadian rhythm of the total hydroxyproline: creatinine ratio in urine C. A. MAUTALEN, Instituto de Investigaciones Medicas, Buenos Aires, 24 October 1973.In a recent paper in Clinical Science Dr Wharton et al. (1973,44,(359)(360)(361)(362)(363)(364)(365) found a significant correlation of both height and weight velocities with the total hydroxyproline : creatinine ratio (THP:Cr) in random urine samples from twenty-six adolescent boys. The validity of results obtained in random samples of urine is based on previous reports where THP:Cr of 24 h specimens was compared with the results obtained in spot samples from the same period. Howells, Wharton & McCance(1967) observed that the ratios were closely correlated (r = 0.98; P

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“…Values are lower in malnutrition conditions like kwashiorkor and marasmus (271,(290)(291)(292) as well as in scurvy (390).…”

Section: U R I M R Y Excretion Of Hydroryproline In Pathological Condmentioning

confidence: 99%