“…Methods for Sequential Design of Experiments (SDoE) exist for a variety of problems, such as optimization (called Bayesian optimization ) (Kushner, 1964 ; Jones et al, 1998 ; Williams et al, 2000 ; Mockus, 2012 ; Shahriari et al, 2016 ; Frazier, 2018 ), contour estimation (Ranjan et al, 2008 ; Picheny et al, 2010 ), estimation of failure probabilities (Bichon et al, 2008 ; Bect et al, 2012 ; Balesdent et al, 2013 ), value of information analysis (Myklebust et al, 2020 ), and Bayesian inverse problems (Sinsbeck and Nowak, 2017 ; Damblin et al, 2018 ; Teckentrup, 2019 ). In all of these methods, the expensive-to-evaluate model function is described by a Gaussian process emulator (GPE).…”