Value of information methods for planning and analyzing clinical studies optimize decision making and research planning

Willan, Andrew R.; Goeree, Ron; Boutis, Kathy

doi:10.1016/j.jclinepi.2012.01.017

Cited by 23 publications

(20 citation statements)

References 24 publications

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“…This approach considers a number of factors such as the relative effectiveness and costs of the evaluated technologies, the decision maker's willingness-to-pay for the additional effectiveness, the probability and consequences of making a suboptimal decision, the population expected to benefit from research findings, the level of implementation (i.e., uptake) of research findings, and the total cost associated with the intended research [54]. Of note, the total cost of research does not only include the direct cost of research in terms of fixed and variable costs but also the opportunity cost from delaying the implementation of the technology awaiting the conclusion of the future trial [27,56]. In addition to sample-size calculation, value of information analysis can optimize other aspects of trial design such as the number of comparators and follow-up duration [29,56].…”

Section: Discussionmentioning

confidence: 99%

“…Of note, the total cost of research does not only include the direct cost of research in terms of fixed and variable costs but also the opportunity cost from delaying the implementation of the technology awaiting the conclusion of the future trial [27,56]. In addition to sample-size calculation, value of information analysis can optimize other aspects of trial design such as the number of comparators and follow-up duration [29,56]. Obviously, more uncertainty is expected to resolve with longer follow-up and more comparator arms albeit with additional research costs.…”

Section: Discussionmentioning

confidence: 99%

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Cost-utility analysis of negative pressure wound therapy in high-risk cesarean section wounds

Tuffaha

Gillespie

Chaboyer

et al. 2015

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cost-utility analysis of negative pressure wound therapy in high-risk cesarean section wounds

Tuffaha

Gillespie

Chaboyer

et al. 2015

Journal of Surgical Research

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“…on new treatments or new tests – becomes available. Furthermore, model-based methods can be used to determine whether a diagnostic RCT may still be worthwhile to conduct and in which specific patient groups, to optimize RCT design [19,51]. …”

Section: Discussionmentioning

confidence: 99%

From accuracy to patient outcome and cost-effectiveness evaluations of diagnostic tests and biomarkers: an exemplary modelling study

Koffijberg

Zaane

Moons

2013

BMC Med Res Methodol

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BackgroundProper evaluation of new diagnostic tests is required to reduce overutilization and to limit potential negative health effects and costs related to testing. A decision analytic modelling approach may be worthwhile when a diagnostic randomized controlled trial is not feasible. We demonstrate this by assessing the cost-effectiveness of modified transesophageal echocardiography (TEE) compared with manual palpation for the detection of atherosclerosis in the ascending aorta.MethodsBased on a previous diagnostic accuracy study, actual Dutch reimbursement data, and evidence from literature we developed a Markov decision analytic model. Cost-effectiveness of modified TEE was assessed for a life time horizon and a health care perspective. Prevalence rates of atherosclerosis were age-dependent and low as well as high rates were applied. Probabilistic sensitivity analysis was applied.ResultsThe model synthesized all available evidence on the risk of stroke in cardiac surgery patients. The modified TEE strategy consistently resulted in more adapted surgical procedures and, hence, a lower risk of stroke and a slightly higher number of life-years. With 10% prevalence of atherosclerosis the incremental cost-effectiveness ratio was €4,651 and €481 per quality-adjusted life year in 55-year-old men and women, respectively. In all patients aged 65 years or older the modified TEE strategy was cost saving and resulted in additional health benefits.ConclusionsDecision analytic modelling to assess the cost-effectiveness of a new diagnostic test based on characteristics, costs and effects of the test itself and of the subsequent treatment options is both feasible and valuable. Our case study on modified TEE suggests that it may reduce the risk of stroke in cardiac surgery patients older than 55 years at acceptable cost-effectiveness levels.

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“…For HIV cure strategies and interventions still in development, it is important to underline the limitations of cost-effectiveness analysis due to the uncertainty in HIV cure research and the potential impact of new interventions. For this reason, other strategies such as mathematical models that include accounting for uncertainty will need to be explored, for example, Value of Information analysis (VOI) which refers to the amount a decision-maker would be willing to pay for information prior to making a decision [32, 33]. These kinds of analytic strategies are detailed by Freedberg and colleagues in reference to HIV cure research, yet economics related research in HIV cure in general has yet to be fully undertaken [34].…”

Section: Community Policy-maker and Funder Perspectivesmentioning

confidence: 99%

Towards Multidisciplinary HIV-Cure Research: Integrating Social Science with Biomedical Research

Grossman

Ross

Auerbach

et al. 2016

Trends in Microbiology

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The quest for a cure for HIV remains a timely and key challenge for the HIV research community. Despite significant scientific advances, current HIV therapy regimens do not completely eliminate the negative impact of HIV on the immune system; and the economic impact of treating all people infected with HIV globally, for the duration of their lifetimes, presents significant challenges. This article discusses, from a multi-disciplinary approach, critical social, behavioral, ethical, and economic issues permeating the HIV cure research agenda. As part of a search for an HIV cure, both the perspective of patients/participants and clinical researchers should be taken into account. In addition, continued efforts should be made to involve and educate the broader community.

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Value of information methods for planning and analyzing clinical studies optimize decision making and research planning

Cited by 23 publications

References 24 publications

Cost-utility analysis of negative pressure wound therapy in high-risk cesarean section wounds

Cost-utility analysis of negative pressure wound therapy in high-risk cesarean section wounds

From accuracy to patient outcome and cost-effectiveness evaluations of diagnostic tests and biomarkers: an exemplary modelling study

Towards Multidisciplinary HIV-Cure Research: Integrating Social Science with Biomedical Research

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