Value of Lifestyle Intervention to Prevent Diabetes and Sequelae

Dall, Timothy M.; Storm, Michael V.; Semilla, April P.; Wintfeld, Neil; O’Grady, Michael J.; Narayan, K.M. Venkat

doi:10.1016/j.amepre.2014.10.003

Cited by 39 publications

(46 citation statements)

References 55 publications

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“…It has been well documented that moderate weight loss has an important impact on the onset and progression of type 2 diabetes and related co-morbidities, lipid disorders as well as hypertension, and could be cost-effective [2,3,4,5]. In the Diabetes Prevention Program (DPP), a mean weight loss of 5.6 kg at 2.8 years resulted in a 58% relative reduction in the risk of type 2 diabetes [2].…”

Section: Introductionmentioning

confidence: 99%

Effects of a Weight Loss Program on Metabolic Syndrome, Eating Disorders and Psychological Outcomes: Mediation by Endocannabinoids

Pataky

Carrard²,

Thomas³

et al. 2018

Obes Facts

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Objective: To evaluate the effects of weight loss on endocannabinoids, cardiometabolic and psychological parameters, eating disorders (ED) as well as quality of life (QoL) and to elucidate the role of endocannabinoids in metabolic syndrome (MS). Methods: In total, 114 patients with obesity were prospectively included in a 12-month weight loss program. Plasma endocannabinoids were measured by mass spectrometry; ED, psychological and QoL-related parameters were evaluated by self-reported questionnaires; physical activity was measured by accelerometer. Nutritional assessment was done by a 3-day food diary. Results: Among completers (n = 87), body weight decreased in 35 patients (-9.1 ± 8.6 kg), remained stable in 39 patients, and increased in 13 patients (+5.8 ± 3.4 kg). 75% of patients with MS at baseline were free of MS at follow-up, and their baseline plasma N-palmitoylethanolamide (PEA) values were significantly lower when compared to patients with persisting MS. At baseline, there was a positive relationship between PEA and waist circumference (p = 0.005, R² = 0.08), fasting glucose (p < 0.0001, R² = 0.12), total cholesterol (p = 0.001, R² = 0.11), triglycerides (p = 0.001, R² = 0.11), LDL-cholesterol (p = 0.03, R² = 0.05) as well as depression score (p = 0.002, R² = 0.29). Conclusion: Plasma PEA might play a role in metabolic improvement after weight loss. Even in subjects without weight loss, a multidisciplinary intervention improves psychological outcomes, ED, and QoL.

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Section: Introductionmentioning

confidence: 99%

Effects of a Weight Loss Program on Metabolic Syndrome, Eating Disorders and Psychological Outcomes: Mediation by Endocannabinoids

Pataky

Carrard²,

Thomas³

et al. 2018

Obes Facts

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“…20 The disease prevention model publication and accompanying technical appendix provide a detailed description of the model data, methods, assumptions, and limitations; and a summary of validation activities and sensitivity analyses as it pertains to diabetes and sequelae. Diabetes and its sequelae are comorbidities of obesity.…”

Section: Methodology Modeling Approach Overviewmentioning

confidence: 99%

“…20 Data sources and parameters for the additional obesity-related health outcomes newly added to the microsimulation model are described below. Appendix 1 summarizes the data sources for each health risk factor and outcome modeled.…”

Section: Populationmentioning

confidence: 99%

“…18;19 A recently published microsimulation model estimated the potential value of weight loss and improved blood glucose levels in helping to prevent diabetes onset and sequelae among a prediabetic population receiving intensive lifestyle intervention. 20 The purpose of this paper is to describe the addition of 25 obesity-related comorbidities to this microsimulation model and to describe validation activities for these added comorbidities. We then use the model to quantify the burden of obesity as it relates to morbidity, medical expenditures, mortality, productivity and quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Modeling the clinical and economic implications of obesity using microsimulation

Su¹,

Huang²,

Chen³

et al. 2015

Journal of Medical Economics

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“…Promoting the health of the physical body in the manner suggested by the PHMS is important because there is a global need to prevent chronic disease, which is possible through proper lifestyle choices (Dall et al, 2015;National Prevention Council, 2012;World Health Organization, 2013). The value of getting enough exercise to maintain physical health has been well documented for many years (Barton & Pretty, 2010;Bo, Jiang, Ji, & Zhang, 2013;Pasanen, Tyrväinen, & Korpela, 2014;Pretty, 2004).…”

Section: The Purna Health Management System and Supporting Western LImentioning

confidence: 99%

How a Himalayan Master and Teacher Promotes Healthy Behavior among His Followers in the Vedic Tradition

Schulz¹

2017

IJSN

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The current article describes how a Himalayan Master and Satguru, Professor and Dr. Sri Svami Purna Maharaj, uses the Vedic/Ayurvedic and other related Himalayan methodology and tradition to address the prevention of disease and promote healthy behavior among the spiritual community of students and seekers through a system developed under his guidance and supervision called the Purna Health Management System (PHMS). The article also explains some of the Vedic/Ayurvedic traditions the PHMS is based on and how they are supported by Western literature and research. Finally, it reports findings of a pilot study investigating outcomes related to selfreported physical health, mental/emotional health, and stress for those who follow the PHMS teachings and framework. The pilot study involved a cross-sectional, mixed-methods anonymous online survey of people who were practicing the PHMS teachings and implementing the system. Out of the 100 potential participants, 41 chose to complete the survey, a 41% response rate. Non-parametric Spearman's ρ Correlation Coefficients were used to test hypotheses for relationships between frequency of implementation of the four key factors of the PHMS and the self-reported outcomes of physical health, mental/emotional health, overall stress level, and ability to manage stress. A two-tailed p < .05 was considered statistically significant. Participants of the pilot study who reported frequently implementing the PHMS also reported positive health outcomes; for example, those who reported implementing the life balance (stress management) aspect of the PHMS more frequently also reported increased physical health, increased mental/emotional health, increased ability to manage stress, and decreased overall stress. Although further research is needed, the findings of this pilot study suggest that the PHMS approach may be useful to both faith communities and health professionals wanting to promote health and prevent disease in those whom they serve.

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Value of Lifestyle Intervention to Prevent Diabetes and Sequelae

Abstract: Lifestyle intervention among people with prediabetes produces long-term societal benefits that exceed anticipated intervention costs, especially among prediabetes patients that meet the ADA and USPSTF screening guidelines.

Cited by 39 publications

References 55 publications

Effects of a Weight Loss Program on Metabolic Syndrome, Eating Disorders and Psychological Outcomes: Mediation by Endocannabinoids

Effects of a Weight Loss Program on Metabolic Syndrome, Eating Disorders and Psychological Outcomes: Mediation by Endocannabinoids

Modeling the clinical and economic implications of obesity using microsimulation

How a Himalayan Master and Teacher Promotes Healthy Behavior among His Followers in the Vedic Tradition

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