Value of measuring gallbladder motility in clinical practice

Lanzini, Alberto; Lotti, Francesco; Baisini, Ornella; Amato, Massimo; Benini, Federica

doi:10.1016/s1590-8658(03)00094-x

Cited by 13 publications

(15 citation statements)

References 30 publications

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“…However, many parameters can affect the response of the gallbladder including the kind of stimulus (intravenous bolus injection, slow infusion of CCK, or a fatty meal to release endogenous CCK) (31, 314, 360, 595-597). Moreover, several studies question the value of measuring gallbladder emptying with the CCK provocative test as a method to select patients with acalculous gallbladder disease for surgery (267,395). Further studies are required to clearly characterize acalculous cholecystitis and the role of CCK in this pathology.…”

Section: Gallbladder Diseasesmentioning

confidence: 99%

Cholecystokinin and Gastrin Receptors

Dufresne

Seva²,

Fourmy³

2006

Physiological Reviews

422

418

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Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of intensive research in the last 10 years with corresponding advances in the understanding of their functioning and physiology. In this review, we first describe general properties of the receptors, such as the different signaling pathways used to exert short- and long-term effects and the structural data that explain their binding properties, activation, and regulation. We then focus on peripheral cholecystokinin receptors by describing their tissue distribution and physiological actions. Finally, pathophysiological peripheral actions of cholecystokinin receptors and their relevance in clinical disorders are reviewed.

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Section: Gallbladder Diseasesmentioning

confidence: 99%

Cholecystokinin and Gastrin Receptors

Dufresne

Seva²,

Fourmy³

2006

Physiological Reviews

422

418

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“…Therefore, prophylactic cholecystectomy or treatment with ursodeoxycholic acid (UDCA) has been recommended for the prevention of gallstones in obese patients undergoing rapid weight loss [4,18]. Yet, it has been shown that normal gallbladder emptying in obese patients undergoing rapid weight loss reduces the risk for gallstone formation to almost zero [19]. Thus, monitoring gallbladder function may help to identify those patients who are at risk and may prevent overtreatment in other patients.…”

Section: Patients At Risk For the Development Of Gallstonesmentioning

confidence: 99%

Mandatory and optional function tests for biliary disorders

Dauer

Lammert

2009

Best Practice & Research Clinical Gastroenterology

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“…As outlined above, the concentration of UDCA in fecal water is near its K D for IBABP, so a signifi cant fraction of IBABP is occupied by this bile acid at its therapeutic concentration. On the basis of the observations presented here, UDCA bound to IBABP is likely to modulate the activity of FXR ␣ in ileocytes and thus enhance the excretion of major human bile acids ( 7,48 ). In addition, UDCA may increase the buffering capacity of IB-ABP in colonocytes.…”

Section: Activation Of Fxr ␣ By Major Human Bile Acids Is Potentiatedmentioning

confidence: 61%