Value of MR imaging in the differentiation of benign and malignant orbital tumors in adults

Abstract

PurposeTo prospectively evaluate magnetic resonance (MR) imaging including dynamic contrast-enhanced MR imaging in the differentiation of benign from malignant orbital masses and to evaluate which MR imaging features are most predictive of malignant tumors.Materials and methodsThe study was approved by the institutional review board and signed informed consent was obtained. Nonenhanced, static, and dynamic contrast-enhanced MR imaging was performed in 102 adult patients with an orbital mass. Diagnosis was based on histologic findings. MR imaging features of benign and malignant orbital lesions were evaluated correlated with histological findings. Multivariate logistic regression analysis was employed to identify the best combination of MR imaging features that might be predictive of malignancy.ResultsNonenhanced, static, and dynamic enhancement MR imaging was significantly superior to two other models in prediction of malignancy (p < 0.05). Multivariate logistic regression analysis identified that the most discriminating MR imaging features were isointense mass on T2-weighted imaging and a washout-type time–intensity curve for both observers.ConclusionNonenhanced, static, and dynamic enhancement MR imaging improved differentiation between benign and malignant orbital masses in adult patients.

Valuation of Four-Quadrant Location Method in Diagnosis and Differential Diagnosis of the Orbital Tumor by Comparison Study Combining CT and MRI with Pathology

“…Most of the benign tumors had well defined margin, oval/round shape, isodensity, low intensity on T1WI, high or slightly signal intensity on T2WI and homogeneous enhancement. Similarly, Xian et al radiological features found that in our results [11]. CT and MRI image study performed for evaluation of the orbital tumor, and certain diagnostic criteria applied in analysis of the orbital tumors, such as patient's age, sex, size, shape, margin, density, CT value, signal intensity, contrast enhancement pattern and invaded adjustment tissues and bone.…”

“…In line with our findings, a previous study found no significant difference in the age and sex of patients with benign versus malignant tumor. The same study reported no significant difference in the side involvement of tumors between the benign versus malignant tumor but previous study showed significant deference between the benign versus malignant tumor [11]. The age of the patients was divided into two group, group A (0-30 years) and group B (>30 years).…”

Value of MR Imaging in Differentiation between Solitary Fibrous Tumor and Schwannoma in the Orbit

“…21,30 Most schwannomas, however, displayed persistent or plateau-shaped curves. Kim et al 2 reported that 3 patients with orbital SFT showed rapid enhancement with early washout of contrast material in the tumors on dual-phase CT.…”

Utility of histogram analysis of ADC maps for differentiating orbital tumors

“…These typical imaging features facilitate their differentiation, and additional use of DWI would not further improve the diagnostic accuracy. Therefore, we excluded these patients, in accordance with previous studies (2,10).…”

“…A retrospective review of our institution's database identified 91 consecutive patients who had undergone DWI scan for pretreatment evaluation of orbital tumors from March 2013 to November 2014. First, similar to previous studies that used DWI to differentiate benign and malignant orbital tumors, patients with cavernous malformation (n=20), lymphangioma (n=1), venous varix (n=4), and epidermoid cyst (n=5) were excluded because of their characteristic findings on routine magnetic resonance imaging (MRI) (2,10). Additionally, four patients were excluded because the largest diameter of the lesion was less than 1 cm and five patients were excluded because of poor image quality.…”