Value of MRI and MIBG-I123 scintigraphy in the diagnosis of spinal bone marrow involvement in, neuroblastoma in children

Najean, B. Bourliere; Siles, S.; Panuel, M.; Cammilleri, Serge; Faure, Frédéric; Devred, P; Kaphan, G.

doi:10.1007/bf02013507

Cited by 16 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone marrow involvement of neuroblastoma in the early stage is apparently nodular, and cytodiagnosis by aspiration biopsy could lead to misleading results in the determination of the neuroblastoma stage. It is necessary to examine bone marrow metastasis by other methods [19][20][21], in addition to cytodiagnosis. Three types of metastasis of neuroblastoma in the medullary cavity, adherent, nodular, and diffuse, depending on the development of bone marrow metastasis, were shown in this study.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic analysis of bone marrow and bone metastasis in murine neuroblastoma

et al. 1996

View full text Add to dashboard Cite

To elucidate the development of bone metastasis in human neuroblastoma, bone marrow and bone metastases were analysed histologically in a hematogeneous metastasis model of murine neuroblastoma. The bone marrow metastasis occurred initially in the bone marrow sinusoid where tumor cells adhered and extravasated to bone marrow parenchyma, resulting in the formation of nodular lesions in the medullary cavity. The nodular lesions eventually progressed to diffuse lesions segmentally occupying the medullary cavity. During the establishment of the diffuse lesions, tumor cells invaded cancellous bone and/or bone cortex, resulting in bone metastasis. Such nodular or diffuse bone marrow metastatic lesions occurred sporadically in a variety of bones. To improve the results of treatment for neuroblastoma, the characteristics of the bone marrow and the bone metastases demonstrated in this study should be considered in the diagnosis and treatment of this disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Histopathologic analysis of bone marrow and bone metastasis in murine neuroblastoma

et al. 1996

View full text Add to dashboard Cite

show abstract

“…Such small BM mets remaining after chemotherapy cannot be detected by conventional methods including MIBG scintigraphy [15,23,24]. MRI is the only useful method to detect such small lesions.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Metastasis of Neuroblastoma Analyzed by MRI and Its Influence on Prognosis

Tanabe

Ohnuma

Iwai

et al. 1995

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

Bone marrow metastases (BM mets) of neuroblastoma were analyzed by magnetic resonance imaging (MRI). BM mets were demonstrated in 45 femurs of 23 patients with neuroblastoma by MRI. They were classified into two patterns, nodular (N) type and diffuse (D) type, on MRI, with an incidence of 16% (7/45) and 84% (38/45), respectively. No bone metastases (B mets) were accompanied by N type BM mets, whereas all of them were accompanied by D type BM mets. The rate of disappearance of N type BM mets after chemotherapy was 100% (7/7) and was significantly higher than that (26%, 10/38) of D type BM mets. The rate of disappearance (58%, 11/19) of BM mets in bones without associated B mets was also significantly higher than that (23%, 6/26) of BM mets in bones with associated B mets. BM mets present in bones with B mets tended to persist after chemotherapy. The survival rate of patients with residual BM mets after chemotherapy was significantly lower than that of patients without residual BM mets. This suggests that powerful systematic chemotherapy and additional targeted therapy to lesions remaining after chemotherapy are needed to improve the cure rate of patients with advanced neuroblastoma.

show abstract

123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma

Bleeker¹,

Tytgat

Adam

et al. 2015

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Background Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest. It is the second most common extracranial malignant solid tumour of childhood. Neuroblastoma cells have the unique capacity to accumulate Iodine‐123‐metaiodobenzylguanidine (¹²³I‐MIBG), which can be used for imaging the tumour. Moreover, ¹²³I‐MIBG scintigraphy is not only important for the diagnosis of neuroblastoma, but also for staging and localization of skeletal lesions. If these are present, MIBG follow‐up scans are used to assess the patient's response to therapy. However, the sensitivity and specificity of ¹²³I‐MIBG scintigraphy to detect neuroblastoma varies according to the literature. Prognosis, treatment and response to therapy of patients with neuroblastoma are currently based on extension scoring of ¹²³I‐MIBG scans. Due to its clinical use and importance, it is necessary to determine the exact diagnostic accuracy of ¹²³I‐MIBG scintigraphy. In case the tumour is not MIBG avid, fluorine‐18‐fluorodeoxy‐glucose ( 18 F‐FDG) positron emission tomography (PET) is often used and the diagnostic accuracy of this test should also be assessed. Objectives Primary objectives: 1.1 To determine the diagnostic accuracy of ¹²³I‐MIBG (single photon emission computed tomography (SPECT), with or without computed tomography (CT)) scintigraphy for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. 1.2 To determine the diagnostic accuracy of negative ¹²³I‐MIBG scintigraphy in combination with 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old, i.e. an add‐on test. Secondary objectives: 2.1 To determine the diagnostic accuracy of 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. 2.2 To compare the diagnostic accuracy of ¹²³I‐MIBG (SPECT‐CT) and 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. This was performed within and between included studies. ¹²³I‐MIBG (SPECT‐CT) scintigraphy was the comparator test in this case. Search methods We searched the databases of MEDLINE/PubMed (1945 to 11 September 2012) and EMBASE/Ovid (1980 to 11 September 2012) for potentially relevant articles. Also we checked the reference lists of relevant articles and review articles, scanned conference proceedings and searched for unpublished studies by contacting researchers involved in this area. Selection criteria We included studies of a cross‐sectional design or cases series of prove...

show abstract

Value of MRI and MIBG-I123 scintigraphy in the diagnosis of spinal bone marrow involvement in, neuroblastoma in children

Cited by 16 publications

References 7 publications

Histopathologic analysis of bone marrow and bone metastasis in murine neuroblastoma

Histopathologic analysis of bone marrow and bone metastasis in murine neuroblastoma

Bone Marrow Metastasis of Neuroblastoma Analyzed by MRI and Its Influence on Prognosis

123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma

Contact Info

Product

Resources

About