Value of <scp><sup>18</sup>F‐FDG‐PET/CT</scp> in the detection of recurrent hepatocellular carcinoma after hepatectomy or radiofrequency ablation: A comparative study with contrast‐enhanced ultrasound

Wang, Xiao Yan; Chen, Dong; Zhang, Xiang Song; Chen, Zhi Feng; Hu, Anbin

doi:10.1111/1751-2980.12064

Cited by 14 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 F-FDG PET-CT can also predict the prognosis of patients with HCC after treatment. 18 F-FDG PET-CT is sensitive to detecting recurrent extrahepatic lesions of HCC after hepatectomy or radiofrequency ablation, which has a diagnostic sensitivity of 90–100% for recurrent or metastatic hepatic tumors[62]. 18 F-FDG PET-CT is a valid prognostic tool in patients with HCC who are candidates for orthotopic liver transplantation (OLT); positivity on PET is the only factor related to early recurrence of HCC after OLT, and the combination of findings on PET and the AFP levels provides even more decisive results[63].…”

Section: F-fdg Petmentioning

confidence: 99%

Positron-emission tomography for hepatocellular carcinoma: Current status and future prospects

Rencai¹,

She²,

Gao³

et al. 2019

WJG

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality worldwide. Various imaging modalities provide important information about HCC for its clinical management. Since positron-emission tomography (PET) or PET-computed tomography was introduced to the oncologic setting, it has played crucial roles in detecting, distinguishing, accurately staging, and evaluating local, residual, and recurrent HCC. PET imaging visualizes tissue metabolic information that is closely associated with treatment. Dynamic PET imaging and dual-tracer have emerged as complementary techniques that aid in various aspects of HCC diagnosis. The advent of new radiotracers and the development of immuno-PET and PET-magnetic resonance imaging have improved the ability to detect lesions and have made great progress in treatment surveillance. The current PET diagnostic capabilities for HCC and the supplementary techniques are reviewed herein.

show abstract

Section: F-fdg Petmentioning

confidence: 99%

Positron-emission tomography for hepatocellular carcinoma: Current status and future prospects

Rencai¹,

She²,

Gao³

et al. 2019

WJG

View full text Add to dashboard Cite

show abstract

“…In comparison to morphological diagnosis, FDG PET evaluates the viability of HCC based on glucose metabolism, not influenced by tumor size, morphology, or lipiodol deposition [5].…”

Section: Introductionmentioning

confidence: 99%

Role of PET CT in comparison to triphasic CT in early follow-up of hepatocellular carcinoma after transarterial chemoemoblization

Hetta

Atyia

2020

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background: The aim of the study is to compare the role of PET/CT and that of triphasic CT in hepatocellular carcinoma post chemoembolization evaluation, thus guiding clinicians for proper management strategy. Thirty patients who had transarterial chemoembolization done for HCC were subjected to both radiological modalities, 18 F-FDG PET/CT and triphasic CT, with the results compared. Results: In our study, triphasic CT revealed 20 true positive results, 3 true negative results, 7 false negative results, and no false positive cases thus exhibiting calculated sensitivity, specificity, and accuracy of 74%, 100.0%, and 76.7% respectively. On the other hand, PET/CT showed 26 true positive results, 2 true negative results, 1 false negative result, and 1 false positive result to exhibit calculated sensitivity, specificity, and accuracy of 96.3%, 66.7%, and 93.3%, respectively. Conclusion: 18 F-FDG PET/CT showed high diagnostic accuracy over triphasic CT in interventional bed evaluation following TACE especially for patients with non-conclusive triphasic CT results and persistent elevated levels of AFP.

show abstract

“…This inconsistency enables FDG to accumulate in HCC but not in normal parenchymal cells. 10 HCCs contain varying levels of this enzyme, and therefore reported sensitivity of FDG-PET/CT scans in detecting hepatocellular carcinoma ranges between 50–70%. 11 Low sensitivity and variation in FDG uptake have been the main reasons for not routinely undergoing FDG-PET/CT in HCC work up.…”

Section: Discussionmentioning

confidence: 99%

Clinical usefulness of FDG-PET in patients with hepatocellular carcinoma undergoing surgical resection

Shin

Choi

2017

Ann Hepatobiliary Pancreat Surg

View full text Add to dashboard Cite

Backgrounds/AimsDiagnosis and staging of hepatocellular carcinoma (HCC) is critical because of the variety of treatment methods and prognosis. [18F]fludeoxyglucose-positron emission tomography/computed tomography ([18F]FDG-PET/CT) has been suggested as a diagnostic modality in HCC. The purpose of this study is to evaluate the accuracy of FDG-PET for staging of HCC after surgical resection and histological confirmation.MethodsWe retrospectively collected data of 56 patients that underwent FDG-PET before surgical resection for HCC March 2011–May 2017, all of whom were suitable for resection by conventional HCC staging. Results of the maximal standardized uptake value (SUVmax) were compared with histological confirmation.ResultsA larger tumor size was related with higher SUVmax (≥4.9). The serum alpha-feto protein was associated with SUVmax. Recurrence rate was higher in patients with higher SUVmax and patients with lower SUVmax had a better survival rate.ConclusionsThe SUVmax correlates well with tumor size and factors associated with biological behavior of HCC such as alpha-feto protein, and it could be a beneficial modality in providing prognostic information for HCC.

show abstract

Value of ¹⁸F‐FDG‐PET/CT in the detection of recurrent hepatocellular carcinoma after hepatectomy or radiofrequency ablation: A comparative study with contrast‐enhanced ultrasound

Abstract: Compared with CEUS, (18) F-FDG-PET/CT has higher sensitivity and accuracy in detecting the local recurrence of HCC after hepatectomy and/or RFA. It can be used to detect recurrent extrahepatic lesions of HCC effectively.

Cited by 14 publications

References 18 publications

Positron-emission tomography for hepatocellular carcinoma: Current status and future prospects

Positron-emission tomography for hepatocellular carcinoma: Current status and future prospects

Role of PET CT in comparison to triphasic CT in early follow-up of hepatocellular carcinoma after transarterial chemoemoblization

Clinical usefulness of FDG-PET in patients with hepatocellular carcinoma undergoing surgical resection

Contact Info

Product

Resources

About

Value of 18F‐FDG‐PET/CT in the detection of recurrent hepatocellular carcinoma after hepatectomy or radiofrequency ablation: A comparative study with contrast‐enhanced ultrasound

Abstract: Compared with CEUS, (18) F-FDG-PET/CT has higher sensitivity and accuracy in detecting the local recurrence of HCC after hepatectomy and/or RFA. It can be used to detect recurrent extrahepatic lesions of HCC effectively.

Cited by 14 publications

References 18 publications

Positron-emission tomography for hepatocellular carcinoma: Current status and future prospects

Positron-emission tomography for hepatocellular carcinoma: Current status and future prospects

Role of PET CT in comparison to triphasic CT in early follow-up of hepatocellular carcinoma after transarterial chemoemoblization

Clinical usefulness of FDG-PET in patients with hepatocellular carcinoma undergoing surgical resection

Contact Info

Product

Resources

About

Value of ¹⁸F‐FDG‐PET/CT in the detection of recurrent hepatocellular carcinoma after hepatectomy or radiofrequency ablation: A comparative study with contrast‐enhanced ultrasound