Value of vitamin D assessment in patients with head and neck squamous cell cancer before treatment

Mostafa, Badr Eldin; Abdelmageed, Heba M.; El-Begermy, Marwa M.; Taha, Mohamed; Hamdy, Tarek Abd-Elhamid; Omran, Azza; Lotfy, Neama M

doi:10.4103/1012-5574.192550

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…In our study, physical activity intensity and serum 25(OH) D concentration were positively associated, as in other head and neck cancer studies (39,(41)(42)(43). There are three possible mechanisms explaining this positive association.…”

Section: Resultssupporting

confidence: 86%

Serum 25-hydroxyvitamin D and nasopharyngeal carcinoma risk and survival: a hospital-based matched prospective case-control study in Malaysia

Ulaganathan,

Lye,

Al-Olayan

et al. 2023

Preprint

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Serum 25(OH) D deficiency may be one of the underlying molecular mechanisms through which chronic inflammation is associated with risk and survival of nasopharyngeal carcinoma (NPC). This study was conducted to determine the association between serum 25(OH) D and NPC risk and survival. A multi-centric case-control study was conducted from two local hospitals. A total of 300 histologically confirmed NPC cases were matched with controls for age, gender and ethnicity and assessed for vitamin D status and other factors. Mean serum 25(OH) D was significantly lower in NPC patients compared with controls (25.3 ± 7.7 ng/mL vs. 27.0 ± 9.2 ng/mL, p = 0.016). Multiple logistic regression analysis indicated that higher levels of serum 25(OH) D was associated with reduced odds of NPC (AOR = 0.73, 95% CI = 0.57–0.94) controlling for confounders including BMI, physical activity, smoking status, alcohol consumption, consumption of food high in vitamin D, salted fish consumption and family history of NPC. There was a significant association between insufficient serum 25 (OH) D status with accumulation of four risk factors and increased odds of getting NPC using fractional polynomial analysis. Increased NPC odds was observed after accumulation of second risk factors with presence insufficient serum 25 (OH) D status (OR = 0.54, 95% CI = 0.27, 4.77, OR = 1.04, 95% CI = 0.64, 1.72, OR = 1.15, 95% CI = 0.73, 1.80, OR = 1.93, 95% CI = 1.13, 3.31, and OR = 5.55, 95% CI = 1.67, 10.3 respectively). The 5-year survival rates were 51.0%, 57.0% and 43.0% for serum 25(OH) D deficiency, insufficiency and sufficient respectively. These findings highlight the potential preventive benefits of maintaining higher levels of serum 25(OH) D in mitigating NPC risk, though further research is needed to explore its impact on survival outcomes.

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Section: Resultssupporting

confidence: 86%

Serum 25-hydroxyvitamin D and nasopharyngeal carcinoma risk and survival: a hospital-based matched prospective case-control study in Malaysia

Ulaganathan,

Lye,

Al-Olayan

et al. 2023

Preprint

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“…There was a decrease in the severity of oral mucositis (a decrease in hyperemia, edema, ulceration, and pain), an improvement in swallowing function, and an increase in the quality of life compared with patients who did not receive vitamin D 3 [15]. The same conclusion was reached by Mostafa et al based on the results of their research [44].…”

Section: Cancer Malignancy Of the Oral Cavitysupporting

confidence: 57%

Vitamin D and Its Role in Oral Diseases Development. Scoping Review

et al. 2021

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Vitamin D is a fat-soluble secosteroid that plays a significant role in the whole body, including the maxillofacial region. The discovery of its receptors in many cells and organs made it possible to reveal the participation of vitamin D not only in the regulation of calcium phosphate metabolism, but also in immune processes, in providing anti-inflammatory and antimicrobial effects, slowing down cell proliferation and stimulating differentiation. In this literature review, we demonstrate the association between low vitamin D levels and the development of recurrent aphthous stomatitis, the course and response to treatment of squamous cell carcinoma of the oral cavity, the severity of periodontal diseases, and the processes of osseointegration and bone remodeling during dental implantation and guided tissue regeneration. The aim of our article was to demonstate a possible connection between vitamin D level and the oral diseases that can be presented at an oral surgery appointment, which will help clinicians to reduce the risk of early dental implant failure, ensure favorable outcomes of augmentative operations, as well as decrease the destructive effects of severe periodontitis and other conditions throug knowledge and timely lab tests and endocrinologist prescriptions.

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“…Various studies conducted by Orell-Kotikangas et al, 20 Grimm et al 13 and Mostafa et al, 21 observed a greater occurrence of Vitamin D insufficiency among patients with OSCC. According to a study by Udeabor et al, 22 a positive association was seen between the incidence of OSCC and Vitamin D deficiency, particularly when the Vitamin D level was below 25 ng/ml.…”

Section: Discussionmentioning

confidence: 93%

Assessment of vitamin D levels in patients with oral potentially malignant disorders and oral squamous cell carcinoma-A cross-sectional study

Samanta,

Patil,

2024

Journal of Oral Biology and Craniofacial Research

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Value of vitamin D assessment in patients with head and neck squamous cell cancer before treatment

Cited by 9 publications

References 48 publications

Serum 25-hydroxyvitamin D and nasopharyngeal carcinoma risk and survival: a hospital-based matched prospective case-control study in Malaysia

Serum 25-hydroxyvitamin D and nasopharyngeal carcinoma risk and survival: a hospital-based matched prospective case-control study in Malaysia

Vitamin D and Its Role in Oral Diseases Development. Scoping Review

Assessment of vitamin D levels in patients with oral potentially malignant disorders and oral squamous cell carcinoma-A cross-sectional study

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