Valve-in-valve outcome: design impact of a pre-existing bioprosthesis on the hydrodynamics of an Edwards Sapien XT valve

Doose, Christian; Kütting, Maximilian; Egron, Sandrine; Ghalati, Pejman Farhadi; Schmitz, Christoph; Utzenrath, Marc; Sedaghat, Alexander; Fujita, Buntaro; Schmitz‐Rode, Thomas; Ensminger, Stephan; Steinseifer, Ulrich

doi:10.1093/ejcts/ezw317

Cited by 12 publications

(11 citation statements)

References 22 publications

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“…One important di↵erence between the two valves is the symmetry breaking in the pericardial leaflets, especially during closure. Because of the asymmetric fiber architecture in each of its leaflets, the bovine pericardial valve shows a swirling motion during closure, as also observed in real pericardial BHVs [55].…”

Section: Resultsmentioning

confidence: 71%

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Lee¹,

Rygg²,

Kolahdouz³

et al. 2019

Preprint

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Computer modeling and simulation (CM&S) is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) that promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance. These computational models are based on a hyperelastic finite element extension of the immersed boundary method for fluid--structure interaction (FSI). We focus on porcine tissue and bovine pericardial BHVs, which are commonly used in surgical valve replacement. We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator. Excellent agreement is demonstrated between the computational and experimental results for bulk flow rates, pressures, valve open areas, and the timing of valve opening and closure in conditions commonly used to assess BHV performance. In addition, reasonable agreement is demonstrated for quantitative measures of leaflet kinematics under these same conditions. This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.

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Section: Resultsmentioning

confidence: 71%

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Lee¹,

Rygg²,

Kolahdouz³

et al. 2019

Preprint

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“…leaflets, the bovine pericardial valve shows a swirling motion during closure, as also observed in real pericardial BHVs. 19 Differences between the porcine valve and bovine pericardial valve resulting from different fiber architectures are also clear in the stress distributions (Fig. 10).…”

Section: Resultsmentioning

confidence: 94%

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

et al. 2020

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Computer modeling and simulation is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) that promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse-duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance. These computational models are based on a hyperelastic finite element extension of the immersed boundary method for fluid–structure interaction (FSI). We focus on porcine tissue and bovine pericardial BHVs, which are commonly used in surgical valve replacement. We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator. Excellent agreement is demonstrated between the computational and experimental results for bulk flow rates, pressures, valve open areas, and the timing of valve opening and closure in conditions commonly used to assess BHV performance. In addition, reasonable agreement is demonstrated for quantitative measures of leaflet kinematics under these same conditions. This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.

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“…PI is a dimensionless index used to quantify valve leaflet deformation severity (wrinkling) and coaptation mismatch. All the valves specifically transcatheter ones pinwheel and high PIs are often associated with low durability therefore accelerated failure of bioprosthetic valve leaflets 5, 9, 23 . One reason of pinwheeling is the high stresses developed on the leaflets as demonstrated by Li et al 20 and Maleki et al 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Where Q represents the root mean square aortic valve flow over the same averaging interval of the PG. The pinwheeling index (PI) is an indicator with implications on leaflet durability and resilience 5, 9, 23 . It is computed from still frames obtained from high-speed imaging as follows and in accordance with Hatoum et al 16 : PI=Lactual-LidealLitalicideal…”

Section: Methodsmentioning

confidence: 99%

Stented valve dynamic behavior induced by polyester fiber leaflet material in transcatheter aortic valve devices

Hatoum

Heim

Dasi

2018

Journal of the Mechanical Behavior of Biomedical Materials

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Valve-in-valve outcome: design impact of a pre-existing bioprosthesis on the hydrodynamics of an Edwards Sapien XT valve

Cited by 12 publications

References 22 publications

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Stented valve dynamic behavior induced by polyester fiber leaflet material in transcatheter aortic valve devices

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