Valvular involvement in granulomatosis with polyangiitis: Case report and systematic review of literature

Al-Habbaa, Ahmed; Rawla, Prashanth; Morra, Mostafa Ebraheem; Abotaha, Ahmed Ahmed; Sakr, Eman Elsayed; Shehata, Mostafa; Shahin, Karim Mohamed; Mageed, Sarah Abdel; Huy, Nguyen Tien

doi:10.1111/echo.14094

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…Postoperative surveillance should be continued for at least 5 years, considering that the mean recurrence period is 4 years. Elderly patients, male patients, and those with aneuploidy DNA content have a poor prognosis and increased mortality [97,99].…”

Section: Solid Pseudopapillary Neoplasm (Spn)mentioning

confidence: 99%

An updated review of pancreatic cystic lesions

Muralidharan¹,

Raj²,

Nathala³

2019

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A pancreatic cystic lesion (PCL) is a collection of fluid in the pancreas, which is often diagnosed incidentally during abdominal imaging, and often poses a diagnostic and therapeutic challenge. PCLs not only have diverse histological and imaging appearances but also differ in clinical presentation, biologic behaviour, growth pattern, and risk of malignancy. Apart from their diagnosis, the management of PCL is also multifactorial, which takes into consideration risk of malignancy, cost of cyst analysis, cyst surveillance, anatomic location of the cyst, the patient's age, and overall health status. Although guidelines exist for surgical and conservative management, each case needs to be tailored to malignant risk, surgical risk, and life expectancy in mind. This would thereby reduce both the monetary and non-monetary burden on patients. In this review, we aim to provide insight into the various recent advances in the diagnosis and management of PCL. Streszczenie Zmiana torbielowata w trzustce (PCL) to zbiornik płynu, który często jest diagnozowany przypadkowo podczas obrazowania jamy brzusznej. Nierzadko stanowi on wyzwanie diagnostyczne i terapeutyczne. Zmiany torbielowate różnią się między sobą wynikami badań histologicznych i obrazowych, a także obrazem klinicznym, cechami biologicznymi, wzorcem wzrostu i ryzykiem nowotworu. Postępowanie w PCL jest wieloczynnikowe, uwzględnia ryzyko złośliwości, koszty analizy torbieli, kontrolę nad torbielą, jej lokalizację anatomiczną, wiek i ogólny stan zdrowia pacjenta. Chociaż istnieją wytyczne dotyczące postępowania chirurgicznego i zachowawczego, każdy przypadek musi być rozpatrywany indywidualnie z uwzględnieniem ryzyka złośliwości, ryzyka chirurgicznego i średniej długości życia. W ten sposób zmniejszyłoby się obciążenie pacjentów-zarówno finansowe, jak i innego rodzaju. Autorzy przedstawiają najnowsze informacje dotyczące postępów w diagnostyce i leczeniu PCL.

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Section: Solid Pseudopapillary Neoplasm (Spn)mentioning

confidence: 99%

An updated review of pancreatic cystic lesions

Muralidharan¹,

Raj²,

Nathala³

2019

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“…However, close monitoring of the patient is warranted because there is a risk of paradoxical haemodynamic instability, which is directly proportional to the amount of fluid tapped [24]. Installation of chemotherapy for malignant tumours directly into the pericardial sac is another potential procedure that needs further exploration [25,26].…”

Section: Pericardial Effusion and Cardiac Tamponadementioning

confidence: 99%

Comprehensive review of oncological emergencies seen in clinical practice

Oben¹,

Fein²

2019

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Aim of the research: To provide an up-to-date review of the literature on the pathophysiology, diagnosis, and management of common oncologic emergencies encountered in clinical practice. Material and methods: We conducted a systematic computerised search in PubMed, Scopus, Web of Science, and Embase. Results: We reviewed relevant medical literature. Most common complications requiring emergency management are addressed in this review, specifically: tumour lysis syndrome, seizures and status epilepticus, pulmonary embolism, leukostasis, thrombotic microangiopathy, febrile neutropaenia, disseminated intravascular coagulation, massive haemoptysis, diffuse alveolar haemorrhage, stem cell transplant-related complications, surgically related complications of malignancy, metastatic spinal cord metastasis, and superior vena cava syndrome. Conclusions: Oncologic emergencies and related complications demand increased attention from attending physicians, oncologists, and intensivists. Knowledge of oncologic emergencies encountered in clinical practice expedites the ability of physicians to manage them properly. The identification and institution of proper management can improve outcomes in these patients. Streszczenie Cel pracy: Przegląd aktualnego piśmiennictwa na temat patofizjologii, diagnostyki i postępowania w nagłych przypadkach onkologicznych w praktyce klinicznej. Materiał i metody: Przeprowadzono systematyczne, komputerowe wyszukiwanie przypadków onkologicznych w bazach PubMed, Scopus, Web of Science i Embase. Wyniki: Dokonano przeglądu odpowiedniej literatury medycznej. W pracy omówiono najczęściej występujące powikłania wymagające pilnego leczenia, takie jak zespół rozpadu guza, napady i stan padaczkowy, zatorowość płucna, leukostaza, mikroangiopatia zakrzepowa, gorączka neutropeniczna, zespół rozsianego wykrzepiania wewnątrznaczyniowego, masywne krwioplucie, rozlane krwawienie pęcherzykowe, powikłania związane z przeszczepem komórek macierzystych, powikłania chirurgiczne związane z nowotworem, przerzuty do rdzenia kręgowego i zespół żyły głównej górnej. Wnioski: Nagłe przypadki onkologiczne oraz związane z nimi powikłania wymagają większej uwagi lekarzy prowadzących, onkologów i lekarzy intensywnej terapii. Znajomość nagłych przypadków onkologicznych spotykanych w praktyce klinicznej pozwala na sprawne ich leczenie. Ustalenie oraz wdrożenie właściwego postępowania umożliwia poprawę wyników leczenia tych chorych.

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“…3 Although cardiac involvement in GPA is quite rare, head and neck manifestations are common in GPA with variable clinical manifestations ranging from mild to potentially life-threatening. 4,5 Subglottic stenosis (SGS) has been estimated to present in approximately 16% to 23% of patients with GPA. 5 Stenosis mainly affects the subglottic or proximal trachea but may extend into the distal trachea and bronchi.…”

Section: Introductionmentioning

confidence: 99%

Current Therapeutic Approaches to Subglottic Stenosis in Patients With GPA: A Systematic Review

et al. 2021

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Background: The management of subglottic stenosis (SGS) in granulomatosis patients with polyangiitis (GPA) has no clear guidelines. This systematic review aimed to identify different surgical techniques and evaluate the outcomes of applied procedures. Methods: An electronic search was performed using 3 major databases, CINAHL, PubMed, and Clinical key, to include relevant studies published from the databases from inception through January 2017. All primary studies reporting treatment of SGS in cases with GPA were included. Articles were excluded if not relevant to the research topic or if they were duplicates, review articles, editorials, short comments, unpublished data, conference abstracts, case reports, animal studies, or non-English studies. Results: Thirteen papers were included in our systematic review with a total of 267 cases for the qualitative review Endoscopic approaches showed favorable outcomes with the need to use multiple procedures to achieve remission. The open transcervical approach showed excellent results mainly after failure of other endoscopic techniques. Tracheostomy was necessary for severe respiratory obstruction symptoms. Medical treatment was essential for stabilizing the active disease and therefore may enhance the success rate postoperatively. Conclusion: Subglottic stenosis in patients with GPA requires a multidisciplinary approach to provide optimal management regarding disease activity, grade of stenosis, and severity of symptoms.

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Valvular involvement in granulomatosis with polyangiitis: Case report and systematic review of literature

Abstract: We recommend routine echocardiography examination to rule out any cardiac valve lesion once GPA is suspected.

Cited by 11 publications

References 34 publications

An updated review of pancreatic cystic lesions

An updated review of pancreatic cystic lesions

Comprehensive review of oncological emergencies seen in clinical practice

Current Therapeutic Approaches to Subglottic Stenosis in Patients With GPA: A Systematic Review

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