Vanadium-Containing Insulin Biomimetic Drugs

Thompson, Katherine H.; McNeill, John H.; Orvig, Chris

doi:10.1007/978-3-642-60061-6_4

Cited by 13 publications

(13 citation statements)

References 111 publications

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“…These studies have shown that this diperoxocomplex seems to be the most toxic compound that has so far been tested on osteoblast-like cells in culture. In order to verify if this toxic action is, eventually, related to the presence of two peroxo groups in the complex, we have now investigated the activity of K 2 [VO (O 2 )NTA]·2H 2 O, containing only one peroxo group, and which has been reported as unusually stable [9] and presenting low toxicity [7,9].…”

Section: Introductionmentioning

confidence: 98%

“…As a part of our studies devoted to the search and characterization of new vanadium complexes with pharmacological activity, in a previous paper, we have investigated in detail the physicochemical and biological behavior of the K 3 [VO (O 2 ) 2 CO 3 ]·H 2 O complex [8]. These studies have shown that this diperoxocomplex seems to be the most toxic compound that has so far been tested on osteoblast-like cells in culture.…”

Section: Introductionmentioning

confidence: 99%

“…Studies on the pharmacological activity of vanadium compounds have awaked great interest during the last years, and different interesting and promising results have been recently reported [1][2][3][4][5][6]. In this context, some vanadium(V) peroxo complexes have shown important antitumoral activity against different experimental systems [1,[4][5][6][7], and it is supposed that their mechanism of action may be different from that of other metallic antitumoral systems [4].…”

Section: Introductionmentioning

confidence: 99%

“…FTIR spectrum of K 2 [VO(O 2 )NTA]·2H2 O in the spectral range between 2,000 and 400 cm −1 molecules were not reported in the structural analysis of the complex[9]. Besides, the deformational mode of these molecules, δ(H 2 O), is evidently overlapped by the strong 1,664-1,615 cm− 1 IR doublet.-Regarding the carboxylate bands, in the free acid, the ν(C=O) vibration is seen as a very strong IR band at 1,726 cm −1 whereas the corresponding ν(C-O) mode appears as a medium intensity band at 1,334 cm −1 .…”

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confidence: 99%

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Spectroscopic Behavior and Biological Activity of K2[VO(O2)NTA]·2H2O

Arrambide

Barrio

Etcheverry

et al. 2009

Biol Trace Elem Res

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The dihydrated potassium salt of the complex anion [VO(O(2))NTA](2-) (NTA = nitrilotriacetate anion, [N(CH(2)-COO)(3)](3-)) was thoroughly characterized by electronic and vibrational (infrared and Raman) spectroscopies. The bioactivity of the complex on the cell proliferation was tested on three cell lines in culture (UMR106 rat osteosarcoma-derived cells, Caco-2 derived from a human colon adenocarcinoma, and RAW 264.7, a macrophage murine cell line).

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Spectroscopic Behavior and Biological Activity of K2[VO(O2)NTA]·2H2O

Arrambide

Barrio

Etcheverry

et al. 2009

Biol Trace Elem Res

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“…The potentiality of simple vanadium compounds and complexes as therapeutic agents has been repeatedly emphasized in recent years, and its insulinmimetic [1][2][3][4][5][6][7], antitumoral [2,3,[8][9][10], antiparasitic [11,12], and antimicrobial activities [13] have been reported.…”

Section: Introductionmentioning

confidence: 99%

Bis(oxalato)dioxovanadate(V) and Bis(oxalato)oxoperoxo-vanadate(V) Complexes: Spectroscopic Characterization and Biological Activity

León

Etcheverry

Parajón‐Costa

et al. 2013

Biol Trace Elem Res

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Two structurally related vanadium(V) complexes, K3[VO2(C2O4)2] · 3H2O and K3[VO(O2)(C2O4)2] · 1/2H2O, were thoroughly characterized by infrared, Raman, and electronic spectroscopies. The effect of both complexes on the viability of the human MG-63 osteosarcoma cells was tested using the MTT assay. The monoperoxo complex shows a very strong antiproliferative activity (at 100-μM concentration, this complex diminished the cell viability ca. 80 %), whereas the dioxo complex was inactive.

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A New Trinuclear Oxovanadium(V) Complex with DMPP Ligands − Synthesis and Structural Characterization in the Solid State and in Aqueous Solution

Avecilla

Geraldes

Castro

2001

Eur. J. Inorg. Chem.

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A new trinuclear oxovanadium(V) complex with the anionic dmpp ligand (Hdmpp = 3-hydroxy-1,2-dimethyl-4-pyridinone), [V 3 O 6 (dmpp) 3 (H 2 O)](H 2 O) 2 , was isolated from the reaction of Hdmpp, KOH and sodium metavanadate at pH 4.5. The solid state structure of the [V 3 O 6 (H 2 O)(dmpp) 3 ](H 2 O) 2 complex, investigated by X-ray diffraction methods, was found to contain a cyclic trinuclear metal cluster. This complex crystallises in the monoclinic system: P2 1 /n, a = 9.5324 (7) Å , b = 16.4107(11) Å and c = 18.0638(12) Å , β = 91.1010(10)°, V = 2825.3(3) Å 3 , Z = 4 and R 1 (wR 2 ) = 0.0704 (0.2025). Two of the vanadium atoms (V1 and V3) are sixcoordinated, with distorted octahedral geometries, and the other one (V2) is five-coordinated with a distorted square pyramidal geometry. The cyclic V 3 O 4 framework has one oxygen atom bridging two vanadium atoms in two V−O−V groups, V1−O4−V2 and V2−O5−V3, and two oxygens bridging the V1−V3 atoms, V1−O6−V3 and V1−O12−V3. IR data confirm the crystallographic results, showing the characteristic V=O band in the 973−935 cm −1 frequency range.This compound has three bands corresponding to V=O stretching, indicative of different chemical environments around the vanadium atoms in the solid state. The ES mass spectrum in aqueous solution displays an intense peak cor-

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Vanadium-Containing Insulin Biomimetic Drugs

Cited by 13 publications

References 111 publications

Spectroscopic Behavior and Biological Activity of K2[VO(O2)NTA]·2H2O

Spectroscopic Behavior and Biological Activity of K2[VO(O2)NTA]·2H2O

Bis(oxalato)dioxovanadate(V) and Bis(oxalato)oxoperoxo-vanadate(V) Complexes: Spectroscopic Characterization and Biological Activity

A New Trinuclear Oxovanadium(V) Complex with DMPP Ligands − Synthesis and Structural Characterization in the Solid State and in Aqueous Solution

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