2003
DOI: 10.1002/jbt.10099
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Vanadium inhibits placental glutathione S‐transferase (GST‐P) positive foci in 1,2‐dimethyl hydrazine induced rat colon carcinogenesis

Abstract: Vanadium (V) has recently been found to possess potent anti-neoplastic activity in rat colon carcinogenesis. In the present study attempts have been made to investigate the expression of the number and area of aberrant crypt foci positive for placental glutathione S-transferase (GST-P) during 1,2-dimethyl hydrazine (DMH)-induced rat colon carcinogenesis. Male Sprague Dawley rats were randomly divided into four groups. Rats in group A were designed as normal controls. Group B animals received DMH once a week (2… Show more

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Cited by 9 publications
(5 citation statements)
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“…8,9 Our laboratory has been working on the chemopreventive efficacy of vanadium in the inhibition of chemically induced carcinomas of liver, colon and mammary gland and has substantially documented the role of vanadium in the prevention of DNA-protein crosslinks, DNA chain break, chromosomal aberrations, 10-15 reduction of tumor incidence and average number of tumors, 16 suppression of tumor marker genes like GST, GST-P, GGT and MT. 17,18 7,12-dimethylbenz(a)anthracene (DMBA) mammary carcinogenesis in rats has been widely used in various mammary cancer chemopreventive studies. 19,20 This model appears to be most relevant to the development of human breast cancer, especially in origin.…”
mentioning
confidence: 99%
“…8,9 Our laboratory has been working on the chemopreventive efficacy of vanadium in the inhibition of chemically induced carcinomas of liver, colon and mammary gland and has substantially documented the role of vanadium in the prevention of DNA-protein crosslinks, DNA chain break, chromosomal aberrations, 10-15 reduction of tumor incidence and average number of tumors, 16 suppression of tumor marker genes like GST, GST-P, GGT and MT. 17,18 7,12-dimethylbenz(a)anthracene (DMBA) mammary carcinogenesis in rats has been widely used in various mammary cancer chemopreventive studies. 19,20 This model appears to be most relevant to the development of human breast cancer, especially in origin.…”
mentioning
confidence: 99%
“…During the last few years, V 5ϩ compounds have been shown to be effective in inhibiting cancers of the liver (Bishayee and Chatterjee, 1995), lung, breast, and gastrointestinal tract (Köpf-Maier, 1987;Kanna et al, 2003Kanna et al, , 2004. The mechanism for this anticancer effect is not known.…”
Section: Discussionmentioning
confidence: 99%
“…The compound was administered at a series of concentrations to healthy, male Sprague Dawley rats for 24 weeks. At weeks 4,8,12,16,20, and 24, their fasting blood plasma insulin, total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), and triglycerides levels were determined. At weeks 6, 10, 14, 18, and 22, the rats were given glucose tolerance tests with the 2-h blood glucose and insulin levels being probed.…”
Section: Discussionmentioning
confidence: 99%
“…Efforts to counter dietary patterns associated with obesity and insulin resistance are likely to reduce colon cancer incidence, as well as cardiovascular disease and diabetes mellitus [1]. Dietary supplements such as conjugated linoleic acid, suggested to increase insulin sensitivity, and vanadate, an insulin mimic, have previously been shown to reduce the incidence of dimethylhydrazine-induced colorectal cancers [3,4]. Thus, therapeutic agents that increase insulin sensitivity and improve cholesterol and triglycerides levels should reduce the incidence of colon cancer.…”
Section: Introductionmentioning
confidence: 99%