Vanadium ionic species from degradation of Ti-6Al-4V metallic implants: In vitro cytotoxicity and speciation evaluation

Costa, Bruna Carolina; Tokuhara, Cíntia Kazuko; Rocha, L. A.; Oliveira, Rodrigo Cardoso de; Lisboa‐Filho, Paulo Noronha; Pessoa, João Costa

doi:10.1016/j.msec.2018.11.090

Cited by 166 publications

(101 citation statements)

References 77 publications

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“…For a nanotubular oxide layer formed on the Ti6Al4V ELI screw, the division into an α-phase rich in aluminum and β-phase rich in vanadium was observed. Despite the presence of toxic vanadium in the β-phase of Ti6Al4V ELI, the anodizing process caused its oxidation reducing toxic effect from a metal substrate [2,35,36]. The oxide layer prepared on Ti6Al4V ELI transpedicular screws are hereinafter designated as: "Ti6Al4V" for bare transpedicular screw, "Compact Ti6Al4V" for transpedicular screw anodized in 1 M H 3 PO 4 resulting in compact oxide formation and "Nanotubular Ti6Al4V" for transpedicular screw anodized in ethylene glycol (99%) with 0.6 wt.% NH 4 F addition resulting in nanotubular layer formation.…”

Section: Anodizing Of Ti6al4v Eli Transpedicular Screwsmentioning

confidence: 99%

“…However, the major concern of using this alloy in clinics is the presence of infiltrated aluminum and vanadium ions in its chemistry, which can potentially increase the expressions of pro-inflammatory factors and cause osteolysis, exhibiting a toxic effect in the body. Products of implant degradation in the form of metallic ions or corrosion products could influence intercellular space or penetrate cells, which leads to metallosis [2]. Therefore, surface treatment methods are very important in forming physicochemical protection and biocompatibility of titanium alloys.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation

2020

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Nano-engineered implants are a promising orthopedic implant modification enhancing bioactivity and integration. Despite the lack of destruction of an oxide layer confirmed in ex vivo and in vivo implantation, the testing of a microrupture of an anodic layer initiating immune-inflammatory reaction is still underexplored. The aim of this work was to form the compact and nanotubular oxide layer on the Ti6Al4V ELI transpedicular screws and electrochemical detection of layer microrupture after implantation ex vivo by the Magerl technique using scanning electron microscopy and highly sensitive electrochemical methods. For the first time, the obtained results showed the ability to form the homogenous nanotubular layer on an Ti6Al4V ELI screw, both in α and β-phases, with favorable morphology, i.e., 35 ÷ 50 ± 5 nm diameter, 1500 ± 100 nm height. In contrast to previous studies, microrupture and degradation of both form layers were observed using ultrasensitive electrochemical methods. Mechanical stability and corrosion protection of nanotubular layer were significantly better when compared to compact oxide layer and bare Ti6Al4V ELI.

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Section: Anodizing Of Ti6al4v Eli Transpedicular Screwsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation

2020

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“…Metallic materials have been extensively applied in surgical implants [1][2][3][4][5]. Among them, titanium (Ti) and its alloys are widely adopted as metallic implants owing to their superior physical and chemical properties [6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a Promising Hierarchical Porous Surface on Titanium for Promoting Biocompatibility

et al. 2020

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The effects of the nano-titanium hydrides (nano-γ-TiH) phase on the formation of nanoporous Ti oxide layer by the potential approach (hydrogen fluoride (HF) pretreatment and sodium hydroxide (NaOH) anodization) were investigated using scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, and transmission electron microscopy. The nano-γ-TiH phase was formed by the HF pretreatment with various current densities. After the NaOH anodization, the nano-γ-TiH phase was dissolved and transformed into nanoporous rutile-Ti dioxide (R-TiO2). As the Ti underwent HF pretreatment and NaOH anodization, the microstructure on the surface layer was transformed from α-Ti → (α-Ti + nano-γ-TiH) → (α-Ti + R-TiO2). In-vitro biocompatibility also indicated that the Ti with a hierarchical porous (micro and nanoporous) TiO2 surface possessed great potential to enhance cell adhesion ability. Thus, the potential approach can be utilized to fabricate a promising hierarchical porous surface on the Ti implant for promoting biocompatibility.

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“…Furthermore, some of the researches also revealed the severe danger of the DNA damage caused by the Ti-6Al-4V alloy [5][6][7]. Vanadium ions were also proven to be toxic to the fibroblasts causing the significant limitation of their viability [8]; therefore, preparation of Ti alloys without these additives should be the prior goal of most researches. One of the possibilities is to produce β-type titanium alloys with low toxicity and high biocompatibility as Ti-Zr-Nb alloys.…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure Evolution, Microstructure Formation, and Properties of Mechanically Alloyed Ultrafine-Grained Ti-Zr-Nb Alloys at 36≤Ti≤70 (at. %)

et al. 2020

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Titanium β-type alloys are preferred biomaterials for hard tissue replacements due to the low Young modulus and limitation of harmful aluminum and vanadium present in the commercially available Ti6Al4V alloy. The aim of this study was to develop a new ternary Ti-Zr-Nb system at 36≤Ti≤70 (at. %). The technical viability of preparing Ti-Zr-Nb alloys by high-energy ball-milling in a SPEX 8000 mill has been studied. These materials were prepared by the combination of mechanical alloying and powder metallurgy approach with cold powder compaction and sintering. Changes in the crystal structure as a function of the milling time were investigated using X-ray diffraction. Our study has shown that mechanical alloying supported by cold pressing and sintering at the temperature below α→β transus (600°C) can be applied to synthesize single-phase, ultrafine-grained, bulk Ti(β)-type Ti30Zr17Nb, Ti23Zr25Nb, Ti30Zr26Nb, Ti22Zr34Nb, and Ti30Zr34Nb alloys. Alloys with lower content of Zr and Nb need higher sintering temperatures to have them fully recrystallized. The properties of developed materials are also engrossing in terms of their biomedical use with Young modulus significantly lower than that of pure titanium.

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Vanadium ionic species from degradation of Ti-6Al-4V metallic implants: In vitro cytotoxicity and speciation evaluation

Cited by 166 publications

References 77 publications

Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation

Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation

Fabrication of a Promising Hierarchical Porous Surface on Titanium for Promoting Biocompatibility

Crystal Structure Evolution, Microstructure Formation, and Properties of Mechanically Alloyed Ultrafine-Grained Ti-Zr-Nb Alloys at 36≤Ti≤70 (at. %)

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