Vancomycin-induced drug reactions with eosinophilia and systemic symptoms syndrome in a patient with positive family history

DeMaio, Alexa; Carlock, Sarah; Winterfield, Laura S

doi:10.5070/d3271156098

Cited by 3 publications

(7 citation statements)

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“…Table 3 and Table 4 present a summary and analysis of 44 cases of eosinophilia caused by vancomycin. 2–8,35–65 Of these 44 cases, drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome, was found in 35 cases. 2–8,35–57 In other cases, some patients had increased eosinophil counts an...…”

Section: Discussionmentioning

confidence: 99%

“…2–8,35–65 Of these 44 cases, drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome, was found in 35 cases. 2–8,35–57 In other cases, some patients had increased eosinophil counts and involvement of other organs such as kidney, lung and heart function due to intravenous use of vancomycin. 58,…”

Section: Discussionmentioning

confidence: 99%

“…58,62,63 Although the reported cases were been clearly diagnosed as DRESS, they were considered to have this syndrome based on the case data. A comprehensive review all of the 44 published cases with eosinophilia caused by vancomycin demonstrated the following (Table 4): 2–8,35–65 male patients were more often affected (27 of 44 patients; 61.4%); the median age was 46.8 years (range, 2 months to 59 years); the median time to vancomycin-related symptoms was 23.5 days (range, 3–49 days); and the median eosinophil count was 5.22 × 10 9 /l (range, 0.85–37.5 × 10 9 /l). Fever (32 of 44 patients; 72.7%) and/or rash (36 of 44 patients; 81.8%) were the first symptoms of eosinophilia in patients with vancomycin treatment; and another two cases had hypotension or were asymptomatic after intraperitoneal injection of vancomycin.…”

Section: Discussionmentioning

confidence: 99%

“…The common adverse reactions of vancomycin include nephrotoxicity, ototoxicity, fever, vancomycin flushing reaction and other symptoms, 1 but there are a growing number of reports of eosinophilia associated with vancomycin use. [2][3][4][5][6][7][8] Oral vancomycin is mainly used to treat and prevent active Clostridium difficile infection. 9,10 Because its absorption rate in the intestinal tract is generally considered to be extremely low, adverse drug events associated with intestinal administration are infrequently reported.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical characteristics of eosinophilia caused by vancomycin reported in 44 cases in the published literature [2][3][4][5][6][7][8]. …”

mentioning

confidence: 99%

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A rare case of infant eosinophilia induced by oral vancomycin: a case report and literature review

Yin

Guo

et al. 2023

J Int Med Res

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Oral vancomycin is mainly used to treat and prevent active Clostridium difficile infection. Because it is widely believed that there is a very low absorption rate via the gastrointestinal tract, reports of adverse reactions following oral vancomycin administration are rare. This case report describes for the first time a case of antibiotic-associated diarrhoea in a 2-month-old infant treated with oral vancomycin. After oral vancomycin treatment, the number of eosinophils increased significantly and the levels gradually recovered after drug withdrawal. A review and analysis of the previously reported adverse reactions caused by oral vancomycin and eosinophilia caused by vancomycin confirm the need for physicians to pay close attention to vancomycin-related adverse reactions, to monitor the required concentration and to measure eosinophil counts in patients with rash-related adverse reactions. Patients with concomitant diseases and children should be monitored for adverse events as it is possible that they have increased gastrointestinal absorption of vancomycin following oral administration. When vancomycin causes eosinophilia, fever and rash, physicians should be alert to the possibility of organ damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Clinical characteristics of eosinophilia caused by vancomycin reported in 44 cases in the published literature [2][3][4][5][6][7][8]. …”

mentioning

confidence: 99%

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A rare case of infant eosinophilia induced by oral vancomycin: a case report and literature review

Yin

Guo

et al. 2023

J Int Med Res

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Diphenhydramine/vancomycin

2022

Reactions Weekly

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Expanding Family Health History to Include Family Medication History

Haga

Orlando

2023

JPM

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The collection of family health history (FHH) is an essential component of clinical practice and an important piece of data for patient risk assessment. However, family history data have generally been limited to diseases and have not included medication history. Family history was a key component of early pharmacogenetic research, confirming the role of genes in drug response. With the substantial number of known pharmacogenes, many affecting response to commonly prescribed medications, and the availability of clinical pharmacogenetic (PGx) tests and guidelines for interpretation, the collection of family medication history can inform testing decisions. This paper explores the roots of family-based pharmacogenetic studies to confirm the role of genes in these complex phenotypes and the benefits and challenges of collecting family medication history as part of family health history intake.

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Vancomycin-induced drug reactions with eosinophilia and systemic symptoms syndrome in a patient with positive family history

Cited by 3 publications

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A rare case of infant eosinophilia induced by oral vancomycin: a case report and literature review

A rare case of infant eosinophilia induced by oral vancomycin: a case report and literature review

Diphenhydramine/vancomycin

Expanding Family Health History to Include Family Medication History

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