Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis: Development, characterization, and ocular biocompatibility

Cardoso, Jéssica Ferreira; Perasoli, Fernanda Barçante; Almeida, Tamires Cunha; Marques, Maria Betânia de Freitas; Toledo, Cibele Rodrigues; Gil, Priscilla Oliveira; Tavares, Harley Da Silva; Paz, Mariana Campos da; Mussel, Wagner da Nova; Magalhães, Juliana Teixeira de; Silva, Glenda Nicioli da; Silva-Cunha, Armando; Granjeiro, Paulo Afonso; Klibanov, Alexander M.; Silva, Gisele Rodrigues Da

doi:10.1016/j.ijbiomac.2020.12.057

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…Hence, there is a need for additional markers that may be derived from the ERG. In addition, given the development of novel therapeutic drug delivery systems such as nanoparticles for the treatment of endophthalmitis, the analysis of features extracted from the ERG may be beneficial as biomarkers in clinical trials [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms

et al. 2023

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Background: The electroretinogram is a clinical test used to assess the function of the photoreceptors and retinal circuits of various cells in the eye, with the recorded waveform being the result of the summated response of neural generators across the retina. Methods: The present investigation involved an analysis of the electroretinogram waveform in both the time and time–frequency domains through the utilization of the discrete wavelet transform and continuous wavelet transform techniques. The primary aim of this study was to monitor and evaluate the effects of treatment in a New Zealand rabbit model of endophthalmitis via electroretinogram waveform analysis and to compare these with normal human electroretinograms. Results: The wavelet scalograms were analyzed using various mother wavelets, including the Daubechies, Ricker, Wavelet Biorthogonal 3.1 (bior3.1), Morlet, Haar, and Gaussian wavelets. Distinctive variances were identified in the wavelet scalograms between rabbit and human electroretinograms. The wavelet scalograms in the rabbit model of endophthalmitis showed recovery with treatment in parallel with the time-domain features. Conclusions: The study compared adult, child, and rabbit electroretinogram responses using DWT and CWT, finding that adult signals had higher power than child signals, and that rabbit signals showed differences in the a-wave and b-wave depending on the type of response tested, while the Haar wavelet was found to be superior in visualizing frequency components in electrophysiological signals for following the treatment of endophthalmitis and may give additional outcome measures for the management of retinal disease.

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Section: Discussionmentioning

confidence: 99%

OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms

et al. 2023

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“…It is an important component of the extracellular matrix and plays a significant role in cell migration and proliferation, which contributes to wound healing, tissue regeneration, and immunomodulation [11,12]. HA seems to be successful in the therapy of various medical problems; however, the dental application of this agent is relatively new [13][14][15]. As the results of some studies have suggested that HA may play bacteriostatic role [16], has the ability to interact with stem cells [17,18], and has tissue regeneration potential [7], it has been employed as a component of different products [13].…”

Section: Introduction 1backgroundmentioning

confidence: 99%

Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis

2021

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The biological activity of hyaluronic acid (HA) has been well-researched during the past decades; however, there are few randomized, controlled trials of its clinical effects in periodontal therapy. The purpose of this study was to evaluate the effect of hyaluronic acid on the principal parameters of periodontal healing. A specific, commercially available formulation designed and registered for professional dental application, composed of 16 mg/mL of cross-linked and 2 mg/mL of non-cross-linked HA, was used as an adjunctive to non-surgical periodontal therapy, and clinical parameters were evaluated after 3 months. The addition of HA to periodontal therapy demonstrated more favorable clinical results regarding reduction in inflammation, measured by bleeding on probing (−6% compared to the control group) and gain in periodontal attachment (1 mm more than control group), while it had no effect on probing depth reduction. No side effects were reported. Our study demonstrated that HA is a safe and easy-to-use biological agent; due to its wide array of properties, it may significantly improve the results of periodontal therapy. However, more long-term studies are needed to investigate whether these favorable effects remain over time.

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Nanoantibiotics to fight multidrug resistant infections by Gram-positive bacteria: hope or reality?

Berini

Orlandi

Gornati

et al. 2022

Biotechnology Advances

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Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis: Development, characterization, and ocular biocompatibility

Cited by 8 publications

References 39 publications

OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms

OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms

Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis

Nanoantibiotics to fight multidrug resistant infections by Gram-positive bacteria: hope or reality?

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