Vancomycin-loaded oxidized hyaluronic acid and adipic acid dihydrazide hydrogel: Bio-compatibility, drug release, antimicrobial activity, and biofilm model

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

“…Moreover, it was suitable to cover the exposed neural structure at the laminectomy site [37]. The hydrogel morphology with interconnected pores promotes nutrition, proliferation, and migration of cells, along with the higher swelling capability justifying its compatibility with various types of cells [73,99,[143][144][145][146][147]. The increased stability with ADH cross-linking is promising for cell cultivation in vitro and repair and regeneration in vivo.…”

Hyaluronic Acid-Based Scaffolds as Potential Bioactive Wound Dressings

“…Liao et al formulated HA-based hydrogel scaffolds loaded with vancomycin. The in vitro drug release profile demonstrated a slightly faster release of vancomycin from the hydrogels at 37 °C within 72 h [ 66 ]. The mean release proportion of loaded antibiotics on the 3rd day was approximately 86%.…”

“…The antibacterial efficacy of the hydrogel against methicillin-resistant S. aureus showed that the average zone of inhibition of vancomycin-loaded hydrogels ranged between 5.7 ± 0.6 and 21.4 ± 0.7 mm post overnight culture. These results can be significantly beneficial in wound treatment [ 66 ]. Dong et al formulated conformable HA-based hydrogels loaded with adipose-derived stem cells for burn injury treatment.…”

Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

“…Aminoethyl methacrylate HA Excellent swelling, mechanical property, low cytotoxicity, rapid hemostasis capacity and facilitated wound healing in mice [101] Alginate-HA fibers Good mechanical performance, high liquid absorption, and swelling percentage, high biocompatibility toward nHDF cell line, maintaining a moist wound surface [102] HA-poloxamer Promoted skin-wound healing and increased protein accumulation in the wound area in rats, higher air permeability than Band-aid [103] HA and lysozyme Hydrogel with suitable viscoelasticity and excellent adhesion on the skin tissue, low cytotoxicity [104] γ-Irradiated LMM HA High viability of L929 skin fibroblasts, faster wound healing after two days of healing in rats [105] HA with conjugated azobenzene and β-cyclo-dextrin groups Hydrogel with fast healing of skin wound in rats [106] • NO-releasing HA derivatives Effective against pathogens Staphylococcus aureus and Pseudomonas aeruginosa in skin wounds, enhanced wound closure and decreased quantity of the P. aeruginosa genetic material in the wound tissue in mice wounds [107] HA and cellulose High swelling capacity in various media [108] HA and hydroxyethyl cellulose Appropriate gelation time, good swelling ability, suitable water evaporation rate, well hemocompatibility, biological compatibility, super absorbent capacity [109] HA and chitosan Treatment of skin ulcers, decreased hydration properties of the dressing and modulation of drug release [82] There are numerous papers reporting preparations of wound dressings composed of three composite wound dressings involving HA biopolymer, e.g., HA, polycaprolactone and encapsulating growth factor [110], HA-povidone-iodine [111], HA, curcumin, pullulan [112], cornstarch/HA/propolis film [113], silk fibroin, HA, sodium alginate composite scaffold [114], HA gel, coenzyme Q10 or vitamin E, benzocaine [115], oxidized HA, vancomycin, adipic acid dihydrazide [116], HA, gelatin, genipin and hinokitiol [117], graphene oxide/copper nanoderivatives-modified chitosan/HA [118], calcium alginate hydrogel loaded with protamine nanoparticles and HA oligosaccharides [119], nanofibrous/gel structure of chitosan-gelatin/chitosan-HA [120], poly dimethylaminoethyl acrylate-HA with Didymocarpus pedicellatus extract hydrogel [121], HA, gelatin and chitosan scaffold [122], HA, silk fibroin, chitosan…”