Vancomycin use in a hospital with high prevalence of Methicillin-Resistant Staphylococcus aureus: comparison with Hospital Infection Control Practices Advisory Committe Guidelines (HICPAC)

Melo, Daniela Oliveira de; Sasaki, Marli; Grinbaum, Renato Satovschi

doi:10.1590/s1413-86702007000100014

Cited by 8 publications

(8 citation statements)

References 39 publications

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“…It is of notice that in both hospitals, MRSA prevalence is high, which justifies the empiric use of vancomycin in the treatment of hospital infections. MRSA prevalence in HU is 41% and 92 (78%) patients received empiric treatment for suspected Gram-positive infections, which is consistent with the results of the study in the other Brazilian hospital (78% of the empiric treatment with vancomycin) [36].…”

Section: Discussionsupporting

confidence: 89%

“…adequate, because of hospital epidemiology (Table 1). In a Brazilian tertiary hospital, the empiric treatment was responsible for 81.1% of appropriate vancomycin use (because of hospital epidemiology) and 65.2% was inappropriate [36]. In other studies, the empiric treatment with vancomycin was considered the second largest category of inappropriate use (26%), and in others two studies it was considered the first, with 67% of inappropriate use [8,27,37].…”

Section: Resultsmentioning

confidence: 99%

“…Studies suggest that, even in the absence of restriction policies, vancomycin use is not more than 40% of the guidelines recommendations [36,38,39,42]. Other studies have shown that antibiotic control measures can reduce total vancomycin use [18,39].…”

Section: Resultsmentioning

confidence: 99%

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Vancomycin use in a brazilian teaching hospital: comparison with the Hospital Infection Controlpractices Advisory Committee Guidelines (HICPAC)

Melo¹,

Ribeiro²

2009

Braz J Infect Dis

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Section: Discussionsupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

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Vancomycin use in a brazilian teaching hospital: comparison with the Hospital Infection Controlpractices Advisory Committee Guidelines (HICPAC)

Melo¹,

Ribeiro²

2009

Braz J Infect Dis

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“…Statistical analysis SPSS version 20.0 was used to analyze the data. Continuous variables were analyzed using Student's t-test.…”

Section: Discussionmentioning

confidence: 99%

Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018

et al. 2019

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Background: Vancomycin is an antibiotic of growing importance in the treatment of hospital-acquired infections; with a particular emphasis on its value in the fight against Methicillin-resistant Staphylococcus aureus. Increasing reports of Vancomycin resistance have raised concerns about the effectiveness of this drug. Drug utilization evaluation has an important role in controlling rational use of antibiotics to prevent the emergence of resistance. Methods: We conducted a retrospective 6-months study at Jafar Ibn Auf pediatric hospital. Data including patient's demographics, diagnosis, Dosage regimen, and treatment duration were reviewed. The concordance of practice with the Hospital Infection Control Practices Advisory Committee (HICPAC) guidelines and principles of antibiotic therapy was assessed. Results: 127 medical records were reviewed in this study. Sepsis (29%) and Pneumonia (19.6%) were the most common indications. Culture test was requested in 20.5% of patients. Monitoring of serum creatinine was carried in 81.1% of patients. Based on HICPAC guidelines vancomycin was administered appropriately in 67.7% percent of cases. Considering the infusion rate, most of patients with specific order were received vancomycin in 1 hour. Conclusions: The results showed that vancomycin was used empirically without subsequent adjustment of the antimicrobial agent according to culture and sensitivity data and lack of paying enough attention to the infusion rate and serum creatinine monitoring.

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“…The rising incidence of MRSA infections has resulted in an increase in the empiric use of glycopeptides (Kim, 2004(Kim, , 2006Kirst et al 1998; Melo et al 2007; Pace and Yang, 2006).…”

Section: Introductionmentioning

confidence: 99%

Performance of 3 real-time PCR assays for direct detection of Staphylococcus aureus and MRSA from clinical samples

Mehta

McClure

Mangold

et al. 2015

Diagnostic Microbiology and Infectious Disease

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Vancomycin use in a hospital with high prevalence of Methicillin-Resistant Staphylococcus aureus: comparison with Hospital Infection Control Practices Advisory Committe Guidelines (HICPAC)

Cited by 8 publications

References 39 publications

Vancomycin use in a brazilian teaching hospital: comparison with the Hospital Infection Controlpractices Advisory Committee Guidelines (HICPAC)

Vancomycin use in a brazilian teaching hospital: comparison with the Hospital Infection Controlpractices Advisory Committee Guidelines (HICPAC)

Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018

Performance of 3 real-time PCR assays for direct detection of Staphylococcus aureus and MRSA from clinical samples

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