Vanillic acid exerts oestrogen-like activities in osteoblast-like UMR 106 cells through MAP kinase (MEK/ERK)-mediated ER signaling pathway

Xi, Hui; Gao, Quan; Zhang, Yan; Wong, Kwok-Chuen; Dai, Yi; Yao, Xin; Wong, Man Sau

doi:10.1016/j.jsbmb.2014.08.002

Cited by 57 publications

(41 citation statements)

References 42 publications

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“…Previously, VA has been reported to exhibit estrogenic activity, and hence we hypothesize that VA may favor the anti-osteoporotic property by acting as estrogen analog (Xiao et al, 2014). Since, estrogen plays a critical role in maintaining bone mineralization and remodeling (turnover) process via regulating the balance between osteoclast and osteoblast (Ozgocmen et al, 2007).…”

Section: Resultsmentioning

confidence: 89%

“…VA is an intermediate compound formed during the conversion of ferulic acid to vanillin (Calixto-Campos et al, 2015). Ample amount of experimental studies has indicated that its beneficial effects on the cardiovascular, nephro and neurological system (Prince et Previously, VA from Sambucus williamsii Hance (SWH) a Chinese herb has been shown to exert osteoprotective effect (estrogen analog) by stimulating the production of osteoblast on UMR 106 cell model (Xiao et al, 2014). However, the anti-osteoporotic activity of VA has not completely explored in an animal model.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Wang¹,

Jiang²,

Gou³

2017

Afr J Tradit Complement Altern Med

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Background: The need for an anti-osteoporotic agent is in high demand since osteoporosis contributes to high rates of disability or impairment (high osteoporotic fracture), morbidity and mortality. Hence, the present study is designed to evaluate the protective effects of vanillic acid (VA) against bilateral ovariectomy-induced osteoporosis in female Sprague-Dawley (SD) rats. Materials and Methods: Forty healthy female adult SD rats were separated in to four groups with sham-operated control with bilateral laprotomy (Sham; n = 10), bilateral overiectomy (OVX; n = 10) group, OVX rats were orallay administrated with 50 mg/kg b.wt of VA (OVX + 50 VA; n = 10) or 100 mg/kg b.wt of VA (OVX + 100 VA; n = 10) for 12 weeks (post-treatment) after 4 weeks of OVX. Results: A significant change in the body weight gain was noted in OVX group, while treatment with VA substantially reverted to normalcy. Meanwhile, the bone mineral density and content (BMD and BMC) were substantially improved on supplementation with VA. Also, the bone turnover markers like calcium (Ca), phosphorous (P), osteocalcin (OC), alkaline phosphatase (ALP) and deoxypyridinoline (DPD) and inflammatory markers (IL-1β, IL-6, and TNF-α) levels were markedly attenuated in VA-treated rats. Moreover, the biomechanical stability was greatly ameliorated with VA administration. Both the dose of VA showed potent anti-osteoporotic activity, but VA 100 mg showed highest protective effects as compared with 50 mg of VA. Conclusion: Based on the outcome, we concluded that VA 100 showed better anti-osteoporotic activity by improving BMD and BMC as well as biomechanical stability and therefore used as an alternative therapy for treating postmenopausal osteoporosis.

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Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Wang¹,

Jiang²,

Gou³

2017

Afr J Tradit Complement Altern Med

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“…CRL-1661) and murine pre-osteoblastic MC3T3-E1 cells were purchased from ATCC (American Type Culture Collection, Manassas, VA, USA) and were routinely cultured as previously described (Xiao et al, 2014b). Bone marrow mesenchymal stem cells (BMSC) were harvested and cultured as previously described (Xiao et al, 2014b). PPD and 17β-oestradiol (E2) (Sigma-Aldrich, St Louis, MO, USA) were dissolved in ethanol to get 10 À 2 M stock, respectively.…”

Section: Cell Culturementioning

confidence: 99%

“…Upon treatment with PPD (10 À 12 M to 10 À 7 M), E2 (10 À 8 M) or vehicle (0.1% ethanol) in the presence or absence of ICI182,780 (10 À 6 M) (Tocris, Minneapoils, MN, USA) or U0126 (10 À 5 M) (Tocris, Bristol, UK) for 24 or 48 h, the proliferation and alkaline phosphatase activities were measured as described in our previous study (Xiao et al, 2014b).…”

Section: Cell Proliferation Assay and Alkaline Phosphatase (Alp) Actimentioning

confidence: 99%

“…Total RNA was isolated and reverse transcribed using our previous method (Xiao et al, 2014b). The sequences of the PCR primers for runt-related transcription factor 2 (Runx2), osteocalcin, ALP, osteoprotegerin (OPG), receptor activator of nuclear factor κB (RANKL) and the house keeping gene glyceraldehydes-3-phosphate dehydrogenase (GAPDH) were shown in Table 1.…”

Section: Real-time Reverse Transcriptase-polymerase Chain Reaction (Rmentioning

confidence: 99%

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An 8-O-4′ norlignan exerts oestrogen-like actions in osteoblastic cells via rapid nongenomic ER signaling pathway

Xiao

Gao

et al. 2015

Journal of Ethnopharmacology

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Therapeutic and Prophylactic Potential of Morama (Tylosema esculentum): A Review

et al. 2015

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Tylosema esculentum (morama) is a highly valued traditional food and source of medicine for the San and other indigenous populations that inhabit the arid to semi-arid parts of Southern Africa. Morama beans are a rich source of phenolic acids, flavonoids, certain fatty acids, non-essential amino acids, certain phytosterols, tannins and minerals. The plant's tuber contains griffonilide, behenic acid and starch. Concoctions of extracts from morama bean, tuber and other local plants are frequently used to treat diarrhoea and digestive disorders by the San and other indigenous populations. Information on composition and bioactivity of phytochemical components of T. esculentum suggests that the polyphenol-rich extracts of the bean testae and cotyledons have great potential as sources of chemicals that inhibit infectious microorganisms (viral, bacterial and fungal, including drug-resistant strains), offer protection against certain non-communicable diseases and promote wound healing and gut health. The potential antinutritional properties of a few morama components are also highlighted. More research is necessary to reveal the full prophylactic and therapeutic potential of the plant against diseases of the current century. Research on domestication and conservation of the plant offers new hope for sustainable utilisation of the plant.

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Vanillic acid exerts oestrogen-like activities in osteoblast-like UMR 106 cells through MAP kinase (MEK/ERK)-mediated ER signaling pathway

Cited by 57 publications

References 42 publications

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

An 8-O-4′ norlignan exerts oestrogen-like actions in osteoblastic cells via rapid nongenomic ER signaling pathway

Therapeutic and Prophylactic Potential of Morama (Tylosema esculentum): A Review

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