Vanishing bile duct syndrome and immunodeficiency preceding the diagnosis of <scp>H</scp>odgkin lymphoma

Yeh, Paul; Lokan, Julie; Grigg, Andrew

doi:10.1111/imj.12609

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…HL occurrence may be preceded by a VBDS [53,57] even by several months [53]. The period of time until HL appearance was 18 months in 75-year-old patient who also had a pre-existent unexplained immunodeficiency [57].…”

Section: Hodgkin's Lymphoma and Vanishing Bile Duct Syndromementioning

confidence: 99%

Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

Mihăilă

2017

IJPPE

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Abstract. The hepatocytolysis raises questions on following therapeutic conduct when it occurs during chemotherapy for Hodgkin's lymphoma, expression of its liver toxicity. But the onset of primary liver Hodgkin's lymphoma, including the form manifested by acute liver failure, poses even greater problems, as in the case of occurrence of vanishing bile duct syndrome -expression of a paraneoplastic syndrome, hemophagocytic lymphohistiocytosis, peliosis hepatis or association of lymphoma with infection with hepatitis viruses or human immunodeficiency virus or different autoimmune diseases. This review summarizes the clinical experience acquired on the relationship between Hodgkin's lymphoma and liver, from the point of view of clinical manifestations, used treatments and clinical evolution. Suggestions on the course of treatment in patients with Hodgkin's lymphoma and liver damage have been formulated starting from the metabolism and elimination of chemotherapy drugs and taking into account the clinical experience of published clinical trials and cases. This review is a synthesis of knowledge obtained in this field, during the time, of therapeutic possibilities and limits, and formulates potential future milestones for research.

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Section: Hodgkin's Lymphoma and Vanishing Bile Duct Syndromementioning

confidence: 99%

Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

Mihăilă

2017

IJPPE

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“…4 No specific biliary epithelial-associated autoantibody has been found in Hodgkin-associated VBDS. 5 There is no known association between EBV status and VBDS. Historically considered a poor prognostic factor, VBDS was associated with a 1-year overall survival of 43% in a series of 37 affected patients.…”

mentioning

confidence: 99%

Lymphadenopathy and Jaundice

Law

Gopal

2015

JAMA Oncol

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A Hispanic man in his 20s with no known medical history presented with worsening abdominal pain over 5 days, persistent pruritus, and scleral icterus. The patient noted swelling on the right side of the neck and a 10-lb weight loss over the past 2 months. He reported a history of moderate alcohol consumption, drinking 1 beer per day during the week and approximately 5 to 8 beers over the weekend, but denied any use of nutritional supplements or illicit drugs. There was no recent travel outside the state. Human immunodeficiency virus test results on admission were negative. Physical examination revealed scleral icterus, jaundice, and a fixed right supraclavicular lymph node conglomerate measuring 6 × 3 cm. There was no cervical, left supraclavicular, axillary, or inguinal lymphadenopathy. Computed tomography of the neck, chest, abdomen, and pelvis demonstrated a large right supraclavicular lymph node, extensive mediastinal lymphadenopathy, a large extracardiac mass abutting the left atrium, hepatomegaly, and multiple splenic lesions. Laboratory evaluation demonstrated a total serum bilirubin level of 10.5 mg/dL with a direct component of 8.4 mg/dL (to convert to micromoles per liter, multiply by 17.104). Renal function was normal. Mild leukopenia and slight thrombocytopenia in the absence of associated anemia was noted on initial complete blood cell count. A liver biopsy was performed, with results shown in Figure 1.

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Immunoglobulin therapy for successful management of prolonged, recurrent jaundice in a young adult male with combined immunodeficiency

Oda

Tsuchiya

Kimura

et al. 2021

Clin J Gastroenterol

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Vanishing bile duct syndrome and immunodeficiency preceding the diagnosis of Hodgkin lymphoma

Cited by 7 publications

References 19 publications

Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

Lymphadenopathy and Jaundice

Immunoglobulin therapy for successful management of prolonged, recurrent jaundice in a young adult male with combined immunodeficiency

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