Vanishing Endometrial Carcinoma

Dubé, Valérie; Macdonald, Denis; Allingham-Hawkins, Diane; Kamel‐Reid, Suzanne; Colgan, Terence J.

doi:10.1097/01.pgp.0000236945.74711.ef

Cited by 9 publications

(1 citation statement)

References 35 publications

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“…Pelvic lymph node metastasis was observed in 3.5% of endometrioid endometrial carcinomas with superficial myometrial invasion, even in carcinoma without myometrial invasion [ 144 ]. In endometrial cancer, especially endometrioid carcinoma, the vanishing cancer phenomenon has been known to occur [ 145 , 146 ]. A cause of spontaneous regression may be an anti-tumor immune response.…”

Section: Newly Proposed Hypothesis On Pathogenesis Of Retroperitoneal...mentioning

confidence: 99%

Primary Retroperitoneal Carcinomas: New Insights into Pathogenesis and Clinical Management in Comparison with Ovarian Carcinomas and Carcinoma of Unknown Primary

Otsuka

2023

Cancers

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Primary retroperitoneal carcinomas are very rare tumors. Their pathogenesis remains unknown but may be associated with that of ovarian carcinomas, considering the similarity in morphology and gender preference. Although metaplasia of coelomic epithelium is the most widely accepted theory, the pathogenesis of retroperitoneal carcinomas may differ by histologic subtype, like ovarian carcinomas. Mucinous carcinoma, which develops in both women and men, may originate in both primordial germ cells and Walthard cell nests that may be derived from the fallopian tube. Serous carcinomas may be associated with endosalpingiosis, the presence of fallopian tube-like epithelium outside the fallopian tube, and a remnant Müllerian tract. Endometrioid and clear cell carcinomas appear to be associated with extraovarian endometriosis. Additionally, both carcinomas in the retroperitoneal lymph nodes may be metastatic diseases from endometrial and/or renal cell cancer that regress spontaneously (carcinoma of unknown primary). Retroperitoneal carcinomas are difficult to diagnose, as they have no characteristic symptoms and signs. Surgery is the cornerstone of treatment, but the necessity of chemotherapy may depend on histological subtype. Further studies are necessary, in particular studies on endosalpingiosis, as endosalpingiosis is a poorly understood condition, although it is associated with the development of both serous and mucinous carcinomas.

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Section: Newly Proposed Hypothesis On Pathogenesis Of Retroperitoneal...mentioning

confidence: 99%