Vanishing twins: a predictor of small-for-gestational age in IVF singletons

Pinborg, Anja; Lidegaard, Øjvind; Freiesleben, Nina la Cour; Andersen, Anders Nyboe

doi:10.1093/humrep/dem225

Cited by 164 publications

(99 citation statements)

References 30 publications

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“…Second, adverse medical events before 20 weeks of gestation (spontaneous one-twin demise or termination) are likely more common among older mothers and may result in a shift of riskier pregnancies from twin to singleton. The surviving twin is at elevated risk of mortality, low birth weight, preterm birth and NICU admissions, 25,26 and contributes to the higher risk of adverse birth outcomes among singletons as opposed to twins.…”

Section: Discussionmentioning

confidence: 99%

Effect of older maternal age on birth outcomes in twin pregnancies: a population-based study

et al. 2010

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Objective: We compared perinatal mortality, preterm birth (<37, <33 and <28 weeks), small for gestational age (SGA), Apgar score (<4), mechanical ventilation (X1 days) and prolonged neonatal intensive care unit (NICU) hospitalization (X13 days) between twins of 25 to 34 and >35-year-old women. Further, we examined whether older maternal age effects were modified by parity or otherwise affected by chorionicity.Study Design: We carried out a population-based retrospective cohort study including all twin births in British Columbia (BC), Canada, from 1999 to 2003. The BC perinatal database registry was used to obtain clinical, behavioral and demographic data. Adjusted odds ratios (OR) with 95% confidence intervals (CI) were calculated using generalized estimating equation models.Result: Overall, twins of older women were more likely to be born preterm (<37 weeks), but not very or extremely preterm (<33 weeks). These twins were not at increased risk of perinatal death, mechanical ventilation or were not SGA compared with twins of younger women. Twins of older primiparous women did not have an elevated risk of NICU hospitalization; twins born to older multiparous women had higher risk (OR ¼ 1.8; 95% CI: 1.2 to 2.6). Analyses restricted to opposite-sex (dichorionic) twins showed that perinatal death, mechanical ventilation and very preterm birth occur less likely among older women (OR ¼ 0.2 (95% CI: 0.0 to 0.8), OR ¼ 0.3 (95% CI: 0.1 to 0.7) and OR ¼ 0.4 (95% CI: 0.2 to 0.7), respectively). Further, the risk of late preterm birth was increased and NICU hospitalization was reduced among opposite-sex twins born to older compared with younger primiparous women (OR ¼ 1.9 (95% CI: 1.3 to 2.8) and OR ¼ 0.2 (95% CI: 0.1 to 0.5), respectively). Conclusion:Twins of older mothers did not have an elevated risk for most adverse birth outcomes, except for late preterm birth. Risks of neonatal care admission may be elevated among older multiparous women.

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Section: Discussionmentioning

confidence: 99%

Effect of older maternal age on birth outcomes in twin pregnancies: a population-based study

et al. 2010

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“…The frequency of diagnosis of VT has increased as twin pregnancies have risen in number following the use of ART and as the diagnostic tool, namely the transvaginal ultrasound, has been improved. The prevalence of VT has been reported at 4%-30% after ART, and the impact on obstetric and neonatal outcome has been discussed [1][2][3][4][5][6][7]. Almog et al [1] compared 57 VT deliveries with 171 matched singleton deliveries after ART and observed lower birth weight, an increased rate of low birth weight <2500 g and an increased rate of delivery at <28 weeks of gestation in the VT group.…”

Section: Discussionmentioning

confidence: 99%

“…Pinborg et al [3,4] conducted a retrospective study, including the cases of VT into the third trimester, and showed higher rates of low birth weight, very low birth weight, preterm delivery, and infant mortality associated with VT. They also showed that these risks were almost entirely because of the demise at >8 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of this syndrome is reported in 4%-30% of all singleton deliveries after the use of assisted reproductive technologies (ART) [1][2][3][4][5][6][7]. The impact of VT on obstetric outcome till date has been unknown.…”

Section: Introductionmentioning

confidence: 99%

“…The impact of VT on obstetric outcome till date has been unknown. Some studies state that VT is associated with lower birth weight and a high-rate of preterm deliveries [1][2][3][4][5] and that significant similarity are present between the obstetric outcome of VT and twin pregnancies. However, other studies have shown that there is no difference between the obstetric outcome of VT and singletons [6,7].…”

Section: Introductionmentioning

confidence: 99%

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