Vapor deposition of cross-linked fluoropolymer barrier coatings onto pre-assembled microfluidic devices

Riche, Carson T.; Marin, Brandon C.; Malmstadt, Noah; Gupta, Malancha

doi:10.1039/c1lc20396g

Cited by 37 publications

(34 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We explored modifying the surface properties of the channels by coating them with a fluoropolymer coating via a vapor-phase technique we have previously demonstrated for modifying channels in poly(dimethylsiloxane) (PDMS) devices (21,22). In brief, initiated chemical vapor deposition (iCVD) was used to coat the channels in stereolithographically fabricated components with poly(1H,1H,2H,2H-perfluorodecyl acrylate-co-ethylene glycol diacrylate), making the channel walls hydrophobic and increasing the contact angle of a water droplet in oil from 67.9°to 138.3° ( Fig.…”

Section: Assembly and Postprocessingmentioning

confidence: 99%

Discrete elements for 3D microfluidics

Bhargava¹,

Thompson

Malmstadt³

2014

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

275

235

View full text Add to dashboard Cite

Microfluidic systems are rapidly becoming commonplace tools for high-precision materials synthesis, biochemical sample preparation, and biophysical analysis. Typically, microfluidic systems are constructed in monolithic form by means of microfabrication and, increasingly, by additive techniques. These methods restrict the design and assembly of truly complex systems by placing unnecessary emphasis on complete functional integration of operational elements in a planar environment. Here, we present a solution based on discrete elements that liberates designers to build large-scale microfluidic systems in three dimensions that are modular, diverse, and predictable by simple network analysis techniques. We develop a sample library of standardized components and connectors manufactured using stereolithography. We predict and validate the flow characteristics of these individual components to design and construct a tunable concentration gradient generator with a scalable number of parallel outputs. We show that these systems are rapidly reconfigurable by constructing three variations of a device for generating monodisperse microdroplets in two distinct size regimes and in a high-throughput mode by simple replacement of emulsifier subcircuits. Finally, we demonstrate the capability for active process monitoring by constructing an optical sensing element for detecting water droplets in a fluorocarbon stream and quantifying their size and frequency. By moving away from large-scale integration toward standardized discrete elements, we demonstrate the potential to reduce the practice of designing and assembling complex 3D microfluidic circuits to a methodology comparable to that found in the electronics industry. modular microfluidics | microfluidic circuit design | 3D-printed microfluidics

show abstract

Section: Assembly and Postprocessingmentioning

confidence: 99%

Discrete elements for 3D microfluidics

Bhargava¹,

Thompson

Malmstadt³

2014

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

275

235

View full text Add to dashboard Cite

show abstract

“…Barrier coating [50,51], microfluidics [52], mechanical properties [53] 2-Hydroxyethyl methacrylate (HEMA)…”

Section: Monomermentioning

confidence: 99%

“…p(PFDA-co-EGDA) was deposited in channels of poly(dimethylsiloxane) (PDMS) microfluidic devices as a barrier coating to prevent diffusion and swelling [50] or to provide an adequate interface for the synthesis of nanoparticles in droplet-flow microfluidic reactors [52]. p(PFDA-co-EGDA) was used to robustly encapsulate IL marbles [51].…”

Section: Copolymers With 1h1h2h2h-perfluorodecyl Acrylate (Pfda)mentioning

confidence: 99%

Vapor Deposition of Fluoropolymer Surfaces

Yagüe

Gleason

2014

Handbook of Fluoropolymer Science and Technology

View full text Add to dashboard Cite

“…Masking the underlying PDMS with a vapordeposited fl uorocarbon barrier fi lm eliminates the possibility of swelling and prevents hydrophobic recovery due to the low glass transition temperature of PDMS. The ability of such fi lms to prevent absorption of low-molecular-weight molecules and resist swelling in organic solvents was recently demonstrated by Riche et al [ 63 ] Use of this fl uorocarbon coating enables synthesis of nanomaterials that are diffi cult to produce using conventional batch reactions. Coated devices were used for more than 24 h without exhibiting signs of degradation or delamination.…”

Section: Selective Permeationmentioning

confidence: 99%

Chemical Vapor Deposition for Solvent‐Free Polymerization at Surfaces

Yagüe

Coclite

Petruczok

et al. 2012

Macro Chemistry & Physics

View full text Add to dashboard Cite

Chemical vapor deposition (CVD) methods are a powerful technology for engineering surfaces. When CVD is combined with the richness of organic chemistry, the resulting polymeric coatings, deposited without solvents, represent an enabling technology in many different fi elds of application. This article focuses on initiated chemical vapor deposition (iCVD), a new technique that utilizes benign reaction conditions to yield conformal and functional polymer thin fi lms. The latest achievements in coating surfaces and 3D substrates with functional materials, and the use of the technique for biotechnology and selective permeation applications are reviewed, and future directions for iCVD technology are discussed.

show abstract

Vapor deposition of cross-linked fluoropolymer barrier coatings onto pre-assembled microfluidic devices

Abstract: The interior surfaces of pre-assembled poly(dimethylsiloxane) (PDMS) microfluidic devices were modified with a cross-linked fluoropolymer barrier coating that significantly increased the chemical compatibility of the devices.

Cited by 37 publications

References 43 publications

Discrete elements for 3D microfluidics

Discrete elements for 3D microfluidics

Vapor Deposition of Fluoropolymer Surfaces

Chemical Vapor Deposition for Solvent‐Free Polymerization at Surfaces

Contact Info

Product

Resources

About