Vapor–liquid and solid–fluid equilibrium for progesterone+CO2, progesterone+propane, and progesterone+n-butane systems at elevated pressures

High-pressure phase diagram of the drug mitotane in compressed and/or supercritical CO2

“…The main advantages of synthetic-static method are: (1) the measurements can be performed in a relatively short time and (2) a small quantity (in mass) of solute is required to investigate a wide range of composition. Typically, in the case of synthetic-static method, the solubility measurements are performed in a variable-volume view cell equipped with a sapphire window for visual observations [13,14]. The equilibrium cell is load with a known amounts of solute and solvent.…”

Phase equilibrium measurements and modelling of ternary system (carbon dioxide+ethanol+palmitic acid)

“…After completion of a measurement at a given pressure, the cell pressure was established at a new value and the experimental procedure was repeated. The experimental procedure adopted for solid-fluid transition measurements was similar to that presented by Favareto and co-workers [18] and by McHugh and Yogan [19].…”

“…The vapour-liquid (VL) and solid-fluid (SF) curves are represented in a p-T diagram. This procedure followed the methodology described by Favareto et al [18] and McHugh and Yogan [19].…”

“…For the SVL equilibrium modelling of the ternary system studied, the isofugacity criterion was used [18,20]…”

Liberação sustentada de progesterona em micro partículas de PHB-V e PHB-V/PCL produzidas em meio super-critico

“…As medidas experimentais de equilíbrio de fases a altas pressões, realizadas neste trabalho, foram conduzidas em uma célula de volume variável com visualização, baseada no método estático sintético, (SANTOS et al 2006, FAVARETO et al 2008a, FAVARETO et al 2008b, TAKEUCHI et al 2008, MOURA et al 2009. A unidade experimental está esquematicamente representada na Figura 9, e consiste basicamente de uma célula de equilíbrio, com duas janelas de safira, uma para observação visual, com 2,5 centímetros de diâmetro e outra para entrada de luz, com 1,5 centímetros de diâmetro, um transdutor de pressão (Smar LD 301) para faixa de pressão de 0 a 400 bar e precisão de 0,1 bar, um programador portátil (Smar, HT 201), para a aquisição de dados de pressão e uma bomba tipo seringa (ISCO 260D), com volume de 260 cm 3 e pressão de até 500 bar.…”