Vapor Toxicity of UDMH in Rats and Dogs from Short Exposures

Weeks, Maurice H; Maxey, G. C.; Sicks, Mary E.; Greene, Earle A.

doi:10.1097/00043764-196207000-00025

Cited by 3 publications

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“…In the absence of quantitative data in humans, the use of animal data is considered a credible approach for developing AEGL values. Toxicity data of varying degrees of completeness are available for several laboratory species, including, rhesus monkeys, dogs, rats, mice, and hamsters (Weeks et al 1963). Most of the animal studies were conducted using 1,1dimethylhydrazine, although limited data suggest that 1,2-dimethylhydrazine exerts similar toxic effects.…”

Section: Role Of the Organization That Drafts Tsdsmentioning

confidence: 99%

“…Behavioral changes and muscle fasciculations in dogs exposed for 15 min to 1,1-dimethylhydrazine at 360 ppm (Weeks et al 1963) served as the basis for deriving AEGL-2 values. Available lethality data in dogs and rats indicated a near linear temporal relationship (n = 0.84 and 0.80 for dogs and rats, respectively).…”

Section: Initial List Of 85 Priority Chemicalsmentioning

confidence: 99%

“…This factor was based primarily on the variability observed in dogs in which responses varied from one of extreme severity (vomiting, tremors, convulsions, and death) to no observable effects. Additionally, Weeks et al (1963) indicated that dogs previously stressed by auditory stimuli may have potentiated their response to dimethylhydrazine. Based on these data, it was assumed that humans may be equally variable in their response to dimethylhydrazine as a result of similar stresses.…”

Section: Initial List Of 85 Priority Chemicalsmentioning

confidence: 99%

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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

2001

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The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Bruce M. Alberts is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. William A. Wulf is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Kenneth I. Shine is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Bruce M. Alberts and Dr. William A. Wulf are chairman and vice chairman, respectively, of the National Research Council.

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Section: Role Of the Organization That Drafts Tsdsmentioning

confidence: 99%

Section: Initial List Of 85 Priority Chemicalsmentioning

confidence: 99%

Section: Initial List Of 85 Priority Chemicalsmentioning

confidence: 99%

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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

2001

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“…Weeks et al (1963) exposed rats and mongrel dogs to various UDMH concentrations for brief time periods and obtained LC50 values for dogs of 22300, 3580 and 981 ppm and for rats of 24500, 8230 and 1410 ppm, for 5, 15, and 60 minutes, respectively.…”

Section: Inhalation and Dermal Studiesmentioning

confidence: 99%

Chronic Inhalation Toxicity of Unsymmetrical Dimethylhydrazine: Oncogenic Effects

Haun¹,

Kinkead²,

Gaworski³

et al. 1984

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“…The increased use of 1,1-dimethylhydrazine (UDMH) as a missile propellant in recent years has necessitated numerous toxicological and pharmacological studies of this compound to obtain information needed for diagnosis and treatment in the event of accidental UDMH exposure in man (refs 2, 3, 4,16,17,24,25,26,36). These studies have also been useful in setting safe threshold limit values, and in establishing proper propellant handling procedures.…”

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confidence: 99%

Pyridoxine (Vitamin B6) Toxicity Literature Review

Schneider¹

1964

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Vapor Toxicity of UDMH in Rats and Dogs from Short Exposures

Cited by 3 publications

References 0 publications

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

Chronic Inhalation Toxicity of Unsymmetrical Dimethylhydrazine: Oncogenic Effects

Pyridoxine (Vitamin B6) Toxicity Literature Review

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