Variability in Saliva Concentration of the Agglutinin Specific for Serotype c Strains of Streptococcus mutans

Magnusson, Ingvar; Ericson, Thomas

doi:10.1159/000260257

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…However, in this study, no influence of the menstrual cycle was observed either on specific antibody reactions or total IgA. Similar observations with regard to total IgA have been reported by other investigators (20).…”

Section: Resultssupporting

confidence: 92%

Salivary immunoglobulin A antibodies reacting with antigens from oral streptococci: longitudinal study in humans

Gahnberg¹,

Krasse²

1981

Infect Immun

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The salivary immunoglobulin A (IgA) activity to antigens from four common oral streptococci was analyzed in samples from five humans. From each individual, parotid and whole saliva were collected 12 times over a period of 4 months. In samples collected at different occasions, the salivary IgA activity varied considerably. The variations showed a covariation with the concentration of total IgA in the saliva samples. A covariation was also found between salivary IgA antibodies of different specificity. It is concluded that reference antigens, in combination with measurement of total IgA concentration, ought to be used when evaluating the salivary IgA response in humans.

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Section: Resultssupporting

confidence: 92%

Salivary immunoglobulin A antibodies reacting with antigens from oral streptococci: longitudinal study in humans

Gahnberg¹,

Krasse²

1981

Infect Immun

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“…5 were obtained from saliva specimens that promoted rapid aggregation. The concentration of aggregating substance present in any given saliva pool would be expected to vary (1, 11,17,20), and thus the rate of aggregate formation and final aggregate size would be expected to vary similarly. This notion is supported by the observation that no substantial variation in the adherence profile was ever noted when lectins replaced saliva as a source of bacterial aggregating substance.…”

Section: Resultsmentioning

confidence: 99%

“…These substances may also be present in the salivary pellicle coating enamel surfaces (7,12,26,28). In the fluid phase, salivary substances, bacterial products, and other microorganisms may interact with oral microbes such that bacterial aggregation results (2, 4, 8-10, 14,16,[20][21][22]. Recolonization of the shedding oral soft tissues and the intraoral spread of bacteria over the surfaces of the teeth is at least partially effected by the adsorption of bacteria from the saliva.…”

mentioning

confidence: 99%

“…Bacterial adherence to oral, intestinal, genitourinary, and respiratory tissues and skin has resulted in new knowledge that provides some rationale for the composition of the indigenous flora of several tissues (5,6,12). In an effort to establish the biochemical recognition mechanisms of bacterial adherence phenomena in the oral cavity, substances with demonstrated bacterial aggregating activity (salivary mucins, secretory immunoglobulins, and lectins) often are included in adherence assay mixtures to serve as blocking agents or probes for specific receptors (8,11,13,16,(18)(19)(20)(21). Adherence studies which include substances that might aggregate test bacteria cannot determine with certainty the relative effects of bacterial aggregation versus surface coating of bacteria on the subsequent adherence event to be measured.…”

mentioning

confidence: 99%

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Effect of bacterial aggregation on the adherence of oral streptococci to hydroxyapatite

Liljemark¹,

Bloomquist

Germaine

1981

Infect Immun

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Several in vitro assay systems to measure the adherence of human dental plaque bacteria to solid surfaces such as teeth, glass, and hydroxyapatite have been published. In many studies a variety of macromolecular solutes have been used to study the adherence process. Often these solutes are able to aggregate the test bacteria and thus may alter the outcome of adherence experiments. In this study, the effects of the aggregation of Streptococcus sanguis on adherence to spheroidal hydroxyapatite is described. Adherence of preformed aggregates and of bacteria which were aggregating during the adherence reaction was examined. Bacteria were aggregated with whole saliva, concanavalin A, and wheat germ lectin. Further effects of the coaggregation of S. mitis and Actinomyces viscosus to saliva-coated spheroidal hydroxyapatite are presented. These studies suggest that formation of large aggregates resulted in a decrease in the numbers of organisms which adhered. In contrast, the formation of small aggregates actually increased the numbers of bacteria that adhered. All increases in adherent bacteria occurred at low concentrations of aggregating substance in which visible bacterial aggregation was not evident. The data indicate that adequate dose-response experiments must be performed to ensure that solutes used as probes to study adherence mechanisms do not affect the adherence simply as a result of aggregation of the test microorganisms.

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Salivary IgA Antibodies to Antigens from Streptococcus Mutans in Human Dental Caries

Challacombe

1978

Advances in Experimental Medicine and Biology

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Variability in Saliva Concentration of the Agglutinin Specific for Serotype c Strains of Streptococcus mutans

Cited by 9 publications

References 4 publications

Salivary immunoglobulin A antibodies reacting with antigens from oral streptococci: longitudinal study in humans

Salivary immunoglobulin A antibodies reacting with antigens from oral streptococci: longitudinal study in humans

Effect of bacterial aggregation on the adherence of oral streptococci to hydroxyapatite

Salivary IgA Antibodies to Antigens from Streptococcus Mutans in Human Dental Caries

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